Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation [0.03%]
线粒体外膜蛋白Vdac1通过活性氧影响HIF通路及肿瘤代谢重编程和炎症微环境的机制研究
M Christiane Brahimi-Horn,Sandy Giuliano,Estelle Saland et al.
M Christiane Brahimi-Horn et al.
Background: Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental con...
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells [0.03%]
丙酮酸脱氢酶缺陷细胞通过代谢可塑性维持增殖能力
Kartik N Rajagopalan,Robert A Egnatchik,Maria A Calvaruso et al.
Kartik N Rajagopalan et al.
Background: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. ...
Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer [0.03%]
correction to：卵巢癌中HSulf-1丢失促进脂质代谢异常
Debarshi Roy,Susmita Mondal,Chen Wang et al.
Debarshi Roy et al.
[This corrects the article DOI: 10.1186/2049-3002-2-13.].
Published Erratum
Cancer & metabolism. 2014 Nov 4:2:24. DOI:10.1186/2049-3002-2-24 2014
Quantification of folate metabolism using transient metabolic flux analysis [0.03%]
使用瞬时代谢通量分析定量叶酸代谢过程
Philip M Tedeschi,Nadine Johnson-Farley,Hongxia Lin et al.
Philip M Tedeschi et al.
Background: Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to ...
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [0.03%]
标签改变了磷酸甘油酸脱氢酶结构并影响其支持细胞增殖的能力
Katherine R Mattaini,Edward J Brignole,Mitali Kini et al.
Katherine R Mattaini et al.
Background: The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for p...
Mitophagy and cancer [0.03%]
线粒体自噬与癌症关系研究进展
Aparajita H Chourasia,Michelle L Boland,Kay F Macleod
Aparajita H Chourasia
Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged mitochondria, thus maintaining...
Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature [0.03%]
生酮饮食治疗胶质瘤患者：两例接受研究者发起的试验的能量限制性生酮饮食方案治疗的病例报道及文献回顾
Kenneth Schwartz,Howard T Chang,Michele Nikolai et al.
Kenneth Schwartz et al.
Background: Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for tre...
Case Reports
Cancer & metabolism. 2015 Mar 25:3:3. DOI:10.1186/s40170-015-0129-1 2015
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate [0.03%]
定量分析缺氧癌细胞中乙酰辅酶A的产生表明乙酸盐贡献显著
Jurre J Kamphorst,Michelle K Chung,Jing Fan et al.
Jurre J Kamphorst et al.
Background: Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly ...
Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism [0.03%]
琥珀酸脱氢酶抑制引起上皮间质转化和重新编程的碳代谢
Paul-Joseph P Aspuria,Sophia Y Lunt,Leif Väremo et al.
Paul-Joseph P Aspuria et al.
Background: Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been fou...
Lucas B Sullivan,Navdeep S Chandel
Lucas B Sullivan
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent paradigm shift has shown that mROS ...