Profiling cancer metabolism at the 'omic' level: a last resort or the next frontier? [0.03%]
从组学水平分析癌症代谢：最后的手段还是下一个前沿？
Susan J Gelman,Gary J Patti
Susan J Gelman
Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism [0.03%]
瓦堡效应-奥托·瓦堡及其对肿瘤代谢影响的生平概述
Angela M Otto
Angela M Otto
Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of t...
Joerg Martin Buescher,Edward M Driggers
Joerg Martin Buescher
Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites. The cellular components from which these -omics regimes are derive...
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells [0.03%]
HIF-1在Oncostatin M依赖的肝细胞代谢重编程中的作用
Nadia Battello,Andreas David Zimmer,Carole Goebel et al.
Nadia Battello et al.
Background: Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer developme...
Elke Katrin Markert,Alexei Vazquez
Elke Katrin Markert
Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands of cancer cells, including but...
Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells [0.03%]
证据表明2-羟基戊二酸在结直肠癌细胞中不易被代谢
Susan J Gelman,Nathaniel G Mahieu,Kevin Cho et al.
Susan J Gelman et al.
Background: Two-hydroxyglutarate (2HG) is present at low concentrations in healthy mammalian cells as both an L and D enantiomer. Both the L and D enantiomers have been implicated in regulating cellular physiology by mech...
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth [0.03%]
线粒体复合物I抑制剂BAY 87-2243减少黑色素瘤肿瘤生长
Laura Schöckel,Andrea Glasauer,Farhan Basit et al.
Laura Schöckel et al.
Background: Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone [0.03%]
靶向谷氨酰胺代谢可使胰腺癌对β-洛奇酮引起的PARP依赖性代谢灾难产生敏感性
Gaurab Chakrabarti,Zachary R Moore,Xiuquan Luo et al.
Gaurab Chakrabarti et al.
Background: Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferatio...
The rate of glycolysis quantitatively mediates specific histone acetylation sites [0.03%]
糖酵解速率定量介导特定组蛋白乙酰化位点
Ahmad A Cluntun,He Huang,Lunzhi Dai et al.
Ahmad A Cluntun et al.
Background: Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the proces...
(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging [0.03%]
用于动态核极化增强磁共振成像研究癌症代谢的带碳-13标记生化探针
Lucia Salamanca-Cardona,Kayvan R Keshari
Lucia Salamanca-Cardona
In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technology in hyperpolarized (HP) magne...