Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells [0.03%]
丙酮酸羧化酶与急性髓系白血病细胞中的马来酸（反应氧中间体）活性相关
Michelle A C Reed,Christian Ludwig,Christopher M Bunce et al.
Michelle A C Reed et al.
Background: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-b...
Johannes C van der Mijn,David J Panka,Andrew K Geissler et al.
Johannes C van der Mijn et al.
Molecular profiling studies of tumor tissue from patients with clear cell renal cell cancer (ccRCC) have revealed extensive metabolic reprogramming in this disease. Associations were found between metabolic reprogramming, histopathologic Fu...
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment [0.03%]
围绕丙酮酸节点的快速交换通量：一种“泄漏细胞”模型，可解释示踪实验中未标记和标记代谢物的增减
Lake-Ee Quek,Menghan Liu,Sanket Joshi et al.
Lake-Ee Quek et al.
Background: Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In (13)C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabell...
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes [0.03%]
与基因和蛋白质表达亚型相关的乳腺癌代谢群簇
Tonje H Haukaas,Leslie R Euceda,Guro F Giskeødegård et al.
Tonje H Haukaas et al.
Background: The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying mechan...
Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool [0.03%]
人结直肠癌、邻近黏膜和粪便的代谢组学及代谢通路网络
Dustin G Brown,Sangeeta Rao,Tiffany L Weir et al.
Dustin G Brown et al.
Background: Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A ...
Molecular characterization of Gleason patterns 3 and 4 prostate cancer using reverse Warburg effect-associated genes [0.03%]
采用与反向瓦伯格效应相关的基因对前列腺癌Gleason 3分型和4分型的分子特征进行表征
Ilinca Georgescu,Robert J Gooding,R Christopher Doiron et al.
Ilinca Georgescu et al.
Background: Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, Gleaso...
Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells [0.03%]
甲硫氨酸胁迫敏感的MDA-MB-468乳腺癌细胞的相关代谢变化
Stacey L Borrego,Johannes Fahrmann,Rupsa Datta et al.
Stacey L Borrego et al.
Background: The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as "methionine dependence" or "methionine stre...
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis [0.03%]
非目标稳定同位素标记与代谢流分析之间的桥梁
Daniel Weindl,Thekla Cordes,Nadia Battello et al.
Daniel Weindl et al.
Background: Metabolism gained increasing interest for the understanding of diseases and to pinpoint therapeutic intervention points. However, classical metabolomics techniques only provide a very static view on metabolism...
Behjatolah Monzavi-Karbassi,Rhonda Gentry,Varinder Kaur et al.
Behjatolah Monzavi-Karbassi et al.
Background: The effect of moderately elevated blood glucose levels among non-diabetic subjects on cancer prognosis is not well described. The goal of this study was to examine the association of elevated random blood gluc...
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments [0.03%]
脂肪酸去饱和作用受抑制对代谢紊乱环境下的癌细胞存活有害
Barrie Peck,Zachary T Schug,Qifeng Zhang et al.
Barrie Peck et al.
Background: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzym...