The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity [0.03%]
α-酮戊二酸脱氢酶在癌症代谢可塑性中的作用
Renaud Vatrinet,Giulia Leone,Monica De Luise et al.
Renaud Vatrinet et al.
Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron ...
Rae-Anne Hardie,Ellen van Dam,Mark Cowley et al.
Rae-Anne Hardie et al.
Background: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic str...
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration [0.03%]
脂肪细胞脂解连接肥胖与乳腺癌生长：脂肪细胞衍生的脂肪酸驱动乳腺癌细胞增殖和迁移
Seher Balaban,Robert F Shearer,Lisa S Lee et al.
Seher Balaban et al.
Background: Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to sup...
The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study [0.03%]
基于嵌套病例对照研究的前列腺癌进展及致死性疾病的肿瘤代谢驱动作用分析
Rachel S Kelly,Jennifer A Sinnott,Jennifer R Rider et al.
Rachel S Kelly et al.
Background: Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism...
Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance [0.03%]
体重控制干预通过逆转肥胖引起的药物抵抗改善达卡巴嗪治疗黑色素瘤的疗效
Parmanand Malvi,Balkrishna Chaube,Shivendra Vikram Singh et al.
Parmanand Malvi et al.
Background: Obesity-related cellular, metabolic, and molecular alterations have been shown to increase cancer risk and tumor progression and are associated with poorer therapeutic outcome in cancer patients. However, the ...
Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma [0.03%]
上皮间质转化诱导与胰腺导管腺癌葡萄糖摄取和乳酸产生的增加相关
Menghan Liu,Lake-Ee Quek,Ghazal Sultani et al.
Menghan Liu et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a common malignancy with dismal prognosis. Metastatic spread and therapeutic resistance, the main causes of PDAC-related mortalities, are both partially underlined by...
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer [0.03%]
乳酸/丙酮酸转运蛋白MCT-1是Wnt的直接靶点，可使结肠癌对3-溴丙酮酸敏感
Stephanie Sprowl-Tanio,Amber N Habowski,Kira T Pate et al.
Stephanie Sprowl-Tanio et al.
Background: There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct...
Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors [0.03%]
内外兼修的抗癌策略：卡路里限制和自噬抑制对Ras阳性肿瘤单独及联合的效应
Laura M Lashinger,Ciara H O&#x;Flanagan,Sarah M Dunlap et al.
Laura M Lashinger et al.
Background: Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimen...
A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis [0.03%]
基于烷基化和GC-MS分析的快速测定游离醋酸和结合醋酸的方法
Sergey Tumanov,Vinay Bulusu,Eyal Gottlieb et al.
Sergey Tumanov et al.
Background: Acetyl-CoA is a key metabolic intermediate with roles in the production of energy and biomass, as well as in metabolic regulation. It was recently found that acetate is crucial for maintaining acetyl-CoA produ...
Mark A Keibler,Thomas M Wasylenko,Joanne K Kelleher et al.
Mark A Keibler et al.
Background: The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division. Intense examina...