Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state [0.03%]
肥胖状态下循环中高水平的瘦素和抵抗素会损害黑色素瘤中达卡巴嗪的治疗效果
Parmanand Malvi,Balkrishna Chaube,Shivendra Vikram Singh et al.
Parmanand Malvi et al.
Background: Obesity is associated with increased risk, poor prognosis and outcome of therapy, in various cancers. Obesity-associated factors or adipokines, especially leptin and resistin, are purported to promote growth, ...
Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA [0.03%]
癌细胞的代谢可塑性允许对NAMPT抑制产生抵抗力但会不可避免地诱导依赖于LDHA
Natthakan Thongon,Chiara Zucal,Vito Giuseppe D&#x;Agostino et al.
Natthakan Thongon et al.
Background: Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to ...
Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [0.03%]
人类线粒体MTHFD2是一种既能以NADP+又能以FAD为辅因子的二氢叶酸还原酶/甲烯四氢叶酸环化水解酶
Minhye Shin,Jessica Momb,Dean R Appling
Minhye Shin
Background: Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for u...
Allison N Lau,William J Israelsen,Jatin Roper et al.
Allison N Lau et al.
Background: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been repor...
Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids [0.03%]
代谢组学指导的通路分析揭示了癌症转移、胆固醇硫酸盐和磷脂之间的联系
Caroline H Johnson,Antonio F Santidrian,Sarah E LeBoeuf et al.
Caroline H Johnson et al.
Background: Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvi...
Molecular features that predict the response to antimetabolite chemotherapies [0.03%]
预测抗代谢化疗反应的分子特征
Mahya Mehrmohamadi,Seong Ho Jeong,Jason W Locasale
Mahya Mehrmohamadi
Background: Antimetabolite chemotherapeutic agents that target cellular metabolism are widely used in the clinic and are thought to exert their anti-cancer effects mainly through non-specific cytotoxic effects. However, p...
Bortezomib resistance in multiple myeloma is associated with increased serine synthesis [0.03%]
硼替佐米耐药与多发性骨髓瘤中苯丙氨酸和丝氨酸的合成增加有关
Esther A Zaal,Wei Wu,Gerrit Jansen et al.
Esther A Zaal et al.
Background: The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread occurrence of resistance. Metabolic alterations play an...
Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities [0.03%]
三阴性乳腺癌细胞的代谢谱分析揭示了代谢弱点
Nathan J Lanning,Joshua P Castle,Simar J Singh et al.
Nathan J Lanning et al.
Background: Among breast cancers, the triple-negative breast cancer (TNBC) subtype has the worst prognosis with no approved targeted therapies and only standard chemotherapy as the backbone of systemic therapy. Unique met...
HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma [0.03%]
缺氧诱导因子脯氨酰羟化酶PHD3调节透明细胞肾细胞癌的翻译和糖代谢
Petra Miikkulainen,Heidi Högel,Krista Rantanen et al.
Petra Miikkulainen et al.
Background: A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway als...
The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox [0.03%]
β-羟基丁酸对自发性小鼠乳腺肿瘤生长、代谢及组蛋白H3乙酰化的影响：一种β-羟基丁酸悖论的证据
Loreta M Rodrigues,Santiago Uribe-Lewis,Basetti Madhu et al.
Loreta M Rodrigues et al.
Background: Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour gro...