CD38 is methylated in prostate cancer and regulates extracellular NAD [0.03%]
CD38在前列腺癌中甲基化并调节细胞外NAD+
Jack Mottahedeh,Michael C Haffner,Tristan R Grogan et al.
Jack Mottahedeh et al.
Background: Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently repo...
Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics [0.03%]
1,25(OH)₂D₃促生存代谢网络的活化不会影响乳腺癌细胞对化疗药物的敏感性
Mohamed A Abu El Maaty,Yasamin Dabiri,Fadi Almouhanna et al.
Mohamed A Abu El Maaty et al.
Background: We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In th...
Manan M Mehta,Samuel E Weinberg,Elizabeth M Steinert et al.
Manan M Mehta et al.
Background: T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1-4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic e...
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors [0.03%]
炎症引起的DNA聚合酶γ的DNA甲基化改变了结肠肿瘤的代谢谱型
Ashley R Maiuri,Hongde Li,Barry D Stein et al.
Ashley R Maiuri et al.
Background: Inflammation, metabolism, and epigenetic modulation are highly interconnected processes that can be altered during tumorigenesis. However, because of the complexity of these interactions, direct cause and effe...
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers [0.03%]
针对己糖激酶1阴性、己糖激酶2阳性肿瘤的精准治疗策略
Shili Xu,Arthur Catapang,Daniel Braas et al.
Shili Xu et al.
Background: Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have n...
Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation [0.03%]
β-羟基丁酸对乳腺癌细胞的代谢表型有影响，但不影响其增殖及化疗和放疗的效果
Catharina Bartmann,Sudha R Janaki Raman,Jessica Flöter et al.
Catharina Bartmann et al.
Background: Ketogenic diets (KDs) or short-term fasting are popular trends amongst supportive approaches for cancer patients. Beta-hydroxybutyrate (3-OHB) is the main physiological ketone body, whose concentration can rea...
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma [0.03%]
PKM2异构体特异性删除可限制软组织肉瘤小鼠模型中的肿瘤发生
Talya L Dayton,Vasilena Gocheva,Kathryn M Miller et al.
Talya L Dayton et al.
Background: Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PK...
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities [0.03%]
异柠檬酸脱氢酶（IDH）突变和野生型胶质瘤球体的代谢特征揭示了特定细胞类型的弱点
Matthew Garrett,Jantzen Sperry,Daniel Braas et al.
Matthew Garrett et al.
Background: There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exo...
Metabolomics of oncogene-specific metabolic reprogramming during breast cancer [0.03%]
乳腺癌发生过程中致癌基因特异性代谢重编程的代谢组学研究
Chen Dai,Jennifer Arceo,James Arnold et al.
Chen Dai et al.
Background: The complex yet interrelated connections between cancer metabolism and oncogenic driver genes are relatively unexplored but have the potential to identify novel biomarkers and drug targets with prognostic and ...
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner [0.03%]
IDH1突变型胶质瘤以2-羟基戊二酸依赖性方式下调磷胆碱和磷乙醇胺合成
Pavithra Viswanath,Marina Radoul,Jose Luis Izquierdo-Garcia et al.
Pavithra Viswanath et al.
Background: Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however...