Stratification of cancer and diabetes based on circulating levels of formate and glucose [0.03%]
基于循环甲酸和葡萄糖水平对癌症和糖尿病进行分层
Matthias Pietzke,Salvador Fernandez Arroyo,David Sumpton et al.
Matthias Pietzke et al.
Background: Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particul...
CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain [0.03%]
CHCHD4通过控制线粒体呼吸链赋予肿瘤细胞代谢弱点
Luke W Thomas,Jenna M Stephen,Cinzia Esposito et al.
Luke W Thomas et al.
Background: Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. Ho...
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer [0.03%]
肿瘤蛋白D54在调节乳腺癌中丙酮酸脱氢酶和二甲双胍细胞毒性的新功能
Yongxian Zhuang,Reynold C Ly,Carleigh V Frazier et al.
Yongxian Zhuang et al.
Background: The role of tumor protein D54 in breast cancer has not been studied and its function in breast cancer remains unclear. In our previous pharmacogenomic studies using lymphoblastoid cell line (LCL), this protein...
Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells [0.03%]
利用运输排除药理学在细胞内定位乳酸脱氢酶活性
Xiangfeng Niu,Ying-Jr Chen,Peter A Crawford et al.
Xiangfeng Niu et al.
Background: Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lac...
p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant [0.03%]
由一种常见的肿瘤衍生突变体介导的适应丝氨酸饥饿的p53效应依然存在
Timothy J Humpton,Andreas K Hock,Oliver D K Maddocks et al.
Timothy J Humpton et al.
Background: In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping to restrain malignant progression. Conversely, unde...
Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer [0.03%]
运动通过患者来源的结直肠癌异种移植模型抑制肿瘤生长和中心碳代谢
Min Lu,Sydney M Sanderson,Amelia Zessin et al.
Min Lu et al.
Background: While self-reported exercise is associated with a reduction in the risk of recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are unknown. Furthermore, the effect of exerc...
Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice [0.03%]
低脂饮食可改善肥胖小鼠急性淋巴细胞白血病的治疗效果
Jonathan Tucci,Waseem Alhushki,Ting Chen et al.
Jonathan Tucci et al.
Background: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer resp...
Alissandra L Hillis,Allison N Lau,Camille X Devoe et al.
Alissandra L Hillis et al.
Background: While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in hum...
Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9) [0.03%]
与前蛋白转化酶枯草杆菌肽kexin 9型有关的肝细胞癌相关高胆固醇血症
Dipti Athavale,Surbhi Chouhan,Vimal Pandey et al.
Dipti Athavale et al.
Background: PCSK9 regulates low-density lipoprotein cholesterol (LDLc) level and has been implicated in hypercholesterolemia. Aberrant plasma lipid profile is often associated with various cancers. Clinically, the relatio...
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation [0.03%]
蛋白质互作及功能分析提示MTHFD2参与RNA加工和翻译
Costas Koufaris,Roland Nilsson
Costas Koufaris
Background: The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as a potential cancer therapeutic target. However, recen...