A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines [0.03%]
一种系统通量分析方法，用于鉴定人类乳腺癌细胞系中的代谢薄弱环节
Sheree D Martin,Sean L McGee
Sheree D Martin
Background: Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival. As such, targeting this metabolic reprograming has re...
HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells [0.03%]
HIF1/2调节糖酵解基因表达对人类白血病干/祖细胞糖酵解功能不重要
Albertus T J Wierenga,Alan Cunningham,Ayşegül Erdem et al.
Albertus T J Wierenga et al.
Background: Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and pr...
SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia [0.03%]
SGLT2抑制通过逆转高胰岛素血症在小鼠中减缓肿瘤生长
Ali R Nasiri,Marcos R Rodrigues,Zongyu Li et al.
Ali R Nasiri et al.
Background: Obesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer. Because sustained weight loss is rarely achieved, therap...
A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin [0.03%]
一个关于Warburg代谢对多柔比星产生遗传冗余影响的酵母表型模型
Sean M Santos,John L Hartman th
Sean M Santos
Background: The influence of the Warburg phenomenon on chemotherapy response is unknown. Saccharomyces cerevisiae mimics the Warburg effect, repressing respiration in the presence of adequate glucose. Yeast phenomic exper...
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer [0.03%]
PEPCK抑制可限制乳酸利用并抑制结直肠癌的生长
Emily D Montal,Kavita Bhalla,Ruby E Dewi et al.
Emily D Montal et al.
Background: Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutri...
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer [0.03%]
丙酮酸烯醇式磷酸羧激酶的抑制作用可阻止乳酸利用并损害结直肠癌的生长
Emily D Montal,Kavita Bhalla,Ruby E Dewi et al.
Emily D Montal et al.
Background: Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutri...
CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism [0.03%]
CHCHD4通过呼吸链介导的代谢调节肿瘤增殖和EMT相关表型
Luke W Thomas,Cinzia Esposito,Jenna M Stephen et al.
Luke W Thomas et al.
Background: Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phen...
Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC [0.03%]
乳腺癌上皮间质转化（EMT）通过减少SDHC表达抑制琥珀酸脱氢酶（SDH）
Gro V Røsland,Sissel E Dyrstad,Deusdedit Tusubira et al.
Gro V Røsland et al.
Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ...
Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate [0.03%]
异柠檬酸脱氢酶1突变癌对绿茶多酚表没食子儿茶素-3- gallate敏感性增强
Tom H Peeters,Krissie Lenting,Vincent Breukels et al.
Tom H Peeters et al.
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) a...
Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B [0.03%]
采用蛋白质组学和生物信息学方法研究乳腺癌模型中一种新型上皮钙黏蛋白剪接变体过度表达相关的分子变化：细胞代谢的变化及乳酸脱氢酶B高表达的鉴定
Marina Rosso,Lara Lapyckyj,María José Besso et al.
Marina Rosso et al.
Background: Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but ...