Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma [0.03%]
二甲双胍增强药物治疗效果并改善弥漫大B细胞淋巴瘤的预后
Anil R Singh,Juan J Gu,Qunling Zhang et al.
Anil R Singh et al.
Background: The treatment of diffuse large B-cell lymphoma (DLBCL) is limited by the development of resistance to therapy, and there is a need to develop novel therapeutic strategies for relapsed and refractory aggressive...
Elizabeth A Brett,Matthias A Sauter,Hans-Günther Machens et al.
Elizabeth A Brett et al.
In 2006, a new model of invasive breast tumor emerged and, since 2011, is gaining recognition and research momentum. "Tumor-associated collagen signatures" describe 3 distinct layers of collagen which radiate outward in shells from the main...
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer [0.03%]
治疗诱导的脂质摄取和重构使前列腺癌易感铁死亡
Kaylyn D Tousignant,Anja Rockstroh,Berwyck L J Poad et al.
Kaylyn D Tousignant et al.
Background: Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, can...
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis [0.03%]
磷酸羟基丙酸激酶DH酶支持肝脏ceramide合成并维持脂质稳态
Yun Pyo Kang,Aimee Falzone,Min Liu et al.
Yun Pyo Kang et al.
Background: d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical f...
Common biochemical properties of metabolic genes recurrently dysregulated in tumors [0.03%]
肿瘤中代谢基因反复调节的常见生化特性
Krishnadev Oruganty,Scott Edward Campit,Sainath Mamde et al.
Krishnadev Oruganty et al.
Background: Tumor initiation and progression are associated with numerous metabolic alterations. However, the biochemical drivers and constraints that contribute to metabolic gene dysregulation are unclear. ...
Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3) [0.03%]
磷果糖激酶-2/果糖-2,6-二磷酸酯酶3调节钙离子泵在胰腺癌的代谢调控中的作用
D A Richardson,P Sritangos,A D James et al.
D A Richardson et al.
Background: High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic duc...
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma [0.03%]
谷氨酰胺酶-1(GLS1)抑制可限制骨肉瘤的转移进展
L Ren,V Ruiz-Rodado,T Dowdy et al.
L Ren et al.
Background: Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary tumor control accompanied by adjuvant chemotherapy, dea...
Daniel R Garza,Rahwa Taddese,Jakob Wirbel et al.
Daniel R Garza et al.
Background: Colorectal cancer (CRC) is a complex multifactorial disease. Increasing evidence suggests that the microbiome is involved in different stages of CRC initiation and progression. Beyond specific pro-oncogenic me...
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy [0.03%]
起源组织决定GOT1依赖性并赋予放射治疗合成致死性
Barbara S Nelson,Lin Lin,Daniel M Kremer et al.
Barbara S Nelson et al.
Background: Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support p...
Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells [0.03%]
胰岛素癌细胞中丙酮酸激酶敲低时胱氨酸分解代谢和丝氨酸生物合成途径支持丙酮酸产生
Lei Yu,Shao Thing Teoh,Elliot Ensink et al.
Lei Yu et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic ...