The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis [0.03%]
将甲酸盐转化为嘌呤刺激mTORC1导致CAD依赖的嘧啶合成激活
Jacqueline Tait-Mulder,Kelly Hodge,David Sumpton et al.
Jacqueline Tait-Mulder et al.
Background: Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it...
Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase [0.03%]
代谢可塑性通过上调葡萄糖-6-磷酸脱氢酶使胰腺癌产生厄洛替尼耐药性
Neha Sharma,Alok Bhushan,Jun He et al.
Neha Sharma et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant forms of cancer. Lack of effective treatment options and drug resistance contributes to the low survival among PDAC patients. In this study, we investigated the metabolic ...
Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells [0.03%]
纠正：缺氧诱导的脂肪酸结合蛋白7的破坏会导致乳腺癌细胞出现类似米色脂肪的分化和产热作用
Masahiro Kawashima,Karim Bensaad,Christos E Zois et al.
Masahiro Kawashima et al.
[This corrects the article DOI: 10.1186/s40170-020-00219-4.]. © The Author(s) 2020.
Published Erratum
Cancer & metabolism. 2020 Aug 10:8:18. DOI:10.1186/s40170-020-00224-7 2020
Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model [0.03%]
正交小鼠模型中人脑胶质母细胞瘤间充质亚型的谷氨酰胺吸收和利用研究
Kristell Oizel,Chendong Yang,Ophelie Renoult et al.
Kristell Oizel et al.
Background: Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchym...
Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway [0.03%]
缺乏富马酸水合酶的肾细胞癌细胞通过激活未折叠蛋白反应和刺激己糖胺生物合成途径对天冬酰胺作出反应
Rony Panarsky,Daniel R Crooks,Andrew N Lane et al.
Rony Panarsky et al.
Background: The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms lead...
Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells [0.03%]
乳腺癌细胞在上皮间质转化过程中对代谢重构和翻译装置适应性的微调
Tamara Fernández-Calero,Marcos Davyt,Karen Perelmuter et al.
Tamara Fernández-Calero et al.
Background: During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insig...
Sophia Eldad,Rachel Hertz,Gilad Vainer et al.
Sophia Eldad et al.
Background: ErbB2 breast cancer still remains an unmet need due to primary and/or acquired resistance to current treatment strategies. MEDICA compounds consist of synthetic long-chain α,ω-dicarboxylic acids previously r...
Takahiko Nakagawa,Miguel A Lanaspa,Inigo San Millan et al.
Takahiko Nakagawa et al.
Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a driving force to develop obesity and metabolic syndrome. Thus, we assume that fructose...
Metabolite AutoPlotter - an application to process and visualise metabolite data in the web browser [0.03%]
代谢产物AutoPlotter - 一个在网页浏览器中处理和可视化代谢数据的应用程序
Matthias Pietzke,Alexei Vazquez
Matthias Pietzke
Background: Metabolomics is gaining popularity as a standard tool for the investigation of biological systems. Yet, parsing metabolomics data in the absence of in-house computational scientists can be overwhelming and tim...
Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells [0.03%]
缺氧诱导的长链脂肪酸结合蛋白7(L-FABP7)在乳腺癌细胞中被破坏并分化成为 beige fat 类似物及产热过程
Masahiro Kawashima,Karim Bensaad,Christos E Zois et al.
Masahiro Kawashima et al.
Background: Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitocho...