In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells [0.03%]
人前恶性及恶性克隆浆细胞中谷氨酰胺反向转运至TCA循环的体内评估
Wilson I Gonsalves,Jin Sung Jang,Erik Jessen et al.
Wilson I Gonsalves et al.
Background: Overexpression of c-Myc is required for the progression of pre-malignant plasma cells in monoclonal gammopathy of undetermined significance (MGUS) to malignant plasma cells in multiple myeloma (MM). c-Myc also...
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function [0.03%]
雌激素相关受体α通过调节线粒体的生物发生和功能直接与p53结合并协同控制结肠癌生长
Humberto De Vitto,Joohyun Ryu,Ali Calderon-Aparicio et al.
Humberto De Vitto et al.
Background: Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive ...
Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis [0.03%]
苹果酸天冬氨酸 shuttle 成分SLC25A12的缺乏可诱导肺转移
H Furkan Alkan,Paul W Vesely,Hubert Hackl et al.
H Furkan Alkan et al.
Background: Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described...
Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate [0.03%]
蛋白质合成抑制剂通过促进葡萄糖-6-磷酸的积累来刺激MondoA转录活性
Blake R Wilde,Mohan R Kaadige,Katrin P Guillen et al.
Blake R Wilde et al.
Background: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk betwe...
The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial [0.03%]
他汀类药物治疗对瘤内胆固醇水平和LDL受体表达的影响：一项机会窗口乳腺癌试验
Maria Feldt,Julien Menard,Ann H Rosendahl et al.
Maria Feldt et al.
Background: Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intrat...
Treatment of glioblastoma multiforme with "classic" 4:1 ketogenic diet total meal replacement [0.03%]
经典4:1酮体饮食全餐替代治疗多形性胶质母细胞瘤
Pavel Klein,Ivana Tyrlikova,Giulio Zuccoli et al.
Pavel Klein et al.
Introduction: Glioblastoma (GBM) has poor survival with standard treatment. Experimental data suggest potential for metabolic treatment with low carbohydrate ketogenic diet (KD). Few human studies of KD in GBM have been d...
Metabolic plasticity of IDH1 -mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition [0.03%]
IDH1突变型胶质瘤细胞系的代谢可塑性是其对谷氨酰胺酶抑制低敏感的原因
Victor Ruiz-Rodado,Adrian Lita,Tyrone Dowdy et al.
Victor Ruiz-Rodado et al.
Background: Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1 mut ) gliomas are considered good candidates for targeting this pathway because of the contributi...
Tanzina Mollick,Sonia Laín
Tanzina Mollick
By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation. Therefore, depleting pyrimidine ribonucleotide pools has lo...
Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling [0.03%]
代谢连接分析揭示扰乱氧化还原稳态可提高K-Ras肿瘤的药物联合疗效
Daniela Gaglio,Marcella Bonanomi,Silvia Valtorta et al.
Daniela Gaglio et al.
Background: Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments t...
Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways [0.03%]
与体质指数相关的分子特性在肿瘤免疫和代谢通路中的作用
Chao Hu,Xiong Chen,Chengyun Yao et al.
Chao Hu et al.
Background: Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tu...