The PD-L1 metabolic interactome intersects with choline metabolism and inflammation [0.03%]
PD-L1代谢交互组与胆碱代谢和炎症相交
Jesus Pacheco-Torres,Marie-France Penet,Yelena Mironchik et al.
Jesus Pacheco-Torres et al.
Background: Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not bee...
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI [0.03%]
基质辅助激光解吸电离飞行时间质谱成像技术在前列腺癌组织代谢差异研究中的应用
Maria K Andersen,Therese S Høiem,Britt S R Claes et al.
Maria K Andersen et al.
Background: Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ther...
Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with localized primary gastrointestinal stromal tumors [0.03%]
18F-FDG PET/CT代谢肿瘤体积和总病变糖酵解量对局限期原发胃肠道间质瘤患者的预后价值研究
Sang Hyun Hwang,Minkyu Jung,Yong Hyu Jeong et al.
Sang Hyun Hwang et al.
Background: This study aimed to evaluate the prognostic value of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with localized primary gastrointestinal st...
RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination [0.03%]
RNF115通过介导APC泛素化促进Wnt/β-catenin信号转导激活从而促进肺腺癌的发展
Xiao-Ting Wu,Yu-Han Wang,Xiao-Yue Cai et al.
Xiao-Ting Wu et al.
Background: Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. ...
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice [0.03%]
SIRT6增强乳腺癌中的氧化磷酸化并促进小鼠乳腺肿瘤发生
Pamela Becherini,Irene Caffa,Francesco Piacente et al.
Pamela Becherini et al.
Background: Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through w...
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells [0.03%]
药物激活丙酮酸激酶M2使代谢重组，导致TXNIP消耗和AMPK活化以用于乳腺癌细胞中的糖酵解
Fadi Almouhanna,Biljana Blagojevic,Suzan Can et al.
Fadi Almouhanna et al.
Background: Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an imp...
Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells [0.03%]
基于细胞内的精氨挑剔型翻译传感器揭示了ASS1阴性细胞中精氨酸饥饿响应及抗性的动态变化规律
Leonard C Rogers,Jing Zhou,Adriana Baker et al.
Leonard C Rogers et al.
Background: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to d...
Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells [0.03%]
无糖培养促进肿瘤细胞的糖类代谢并使其易于受维生素K3诱导
Cameron A Schmidt,Kelsey L McLaughlin,Ilya N Boykov et al.
Cameron A Schmidt et al.
Background: Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms. Treatment of late-stage HCC relies heavily on chemotherapeutics, m...
PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner [0.03%]
PKC-ζ依赖型的PEPCK-M恢复肿瘤细胞的合成代谢潜能
Petra Hyroššová,Marc Aragó,Juan Moreno-Felici et al.
Petra Hyroššová et al.
Background: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4...
Shilpa R Nagarajan,Lisa M Butler,Andrew J Hoy
Shilpa R Nagarajan
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factor...