Violet A Kiesel,Madeline P Sheeley,Michael F Coleman et al.
Violet A Kiesel et al.
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential rol...
TNF-α differentially modulates subunit levels of respiratory electron transport complexes of ER/PR +ve/-ve breast cancer cells to regulate mitochondrial complex activity and tumorigenic potential [0.03%]
肿瘤坏死因子-α通过调节乳腺癌细胞的线粒体复合物活性和致瘤潜力来差异性地调节呼吸电子转运复合物的亚基水平（雌激素受体/孕酮受体阳性/阴性）
Anjali Shinde,Hyeryeon Jung,Hayun Lee et al.
Anjali Shinde et al.
Background: Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell survi...
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness [0.03%]
胶质瘤进展过程中谷氨酰胺代谢动力学与肿瘤侵袭性相关
Yollanda E Moreira Franco,Maria Jose Alves,Miyuki Uno et al.
Yollanda E Moreira Franco et al.
Background: Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy...
Mitochondrial metabolism as a target for acute myeloid leukemia treatment [0.03%]
以线粒体代谢为靶点治疗急性髓系白血病
Svetlana B Panina,Jingqi Pei,Natalia V Kirienko
Svetlana B Panina
Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of all ages. Despite decades of research, standard chemotherapy stil...
Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1 [0.03%]
肿瘤抑制因子SMAR1通过HDAC6介导的PTBP1去乙酰化调节PKM可变剪接
Arpankumar Choksi,Apoorva Parulekar,Richa Pant et al.
Arpankumar Choksi et al.
Background: Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in th...
Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial [0.03%]
中心性肥胖与DDX11作为小型透明细胞肾细胞癌侵袭性的预测因子之间的关联：一项前瞻性临床试验
Jee Soo Park,Won Sik Jang,Jongchan Kim et al.
Jee Soo Park et al.
Background: Visceral fat produces several hormones and cytokines associated with carcinogenesis and tumor progression. Herein, we investigated the association between visceral adiposity and target-gene mRNA expression in ...
A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism [0.03%]
一种小分子I类葡萄糖 transporter 抑制剂通过针对基于葡萄糖的代谢降低体外癌细胞增殖和体内肿瘤生长
Pratik Shriwas,Dennis Roberts,Yunsheng Li et al.
Pratik Shriwas et al.
Background: Cancer cells drastically increase the uptake of glucose and glucose metabolism by overexpressing class I glucose transporters (GLUT1-4) to meet their energy and biomass synthesis needs and are very sensitive a...
Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes [0.03%]
IDH突变和非突变软骨肉瘤表现出不同的细胞代谢组学特征
Sinthu Pathmanapan,Olga Ilkayeva,John T Martin et al.
Sinthu Pathmanapan et al.
Background: Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enz...
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase [0.03%]
GLUT5（SLC2A5）独立于酮己六激酶介导果糖诱导的细胞增殖
Roger J Liang,Samuel Taylor,Navid Nahiyaan et al.
Roger J Liang et al.
Background: Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the ability to metabolize fructose have a ...
Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models [0.03%]
磺胺水杨酸改变代谢谱型并增强顺铂对体内外胆管癌细胞的化疗敏感性
Malinee Thanee,Sureerat Padthaisong,Manida Suksawat et al.
Malinee Thanee et al.
Background: Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no ...