Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma [0.03%]
基于全球代谢组及脂质组整合分析揭示早期胆管癌术后复发的分子机制及潜在标志物
Sureerat Padthaisong,Jutarop Phetcharaburanin,Poramate Klanrit et al.
Sureerat Padthaisong et al.
Background: Cholangiocarcioma (CCA) treatment is challenging because most of the patients are diagnosed when the disease is advanced, and cancer recurrence is the main problem after treatment, leading to low survival rate...
Inflammatory metabolic profile of South African patients with prostate cancer [0.03%]
南非前列腺癌患者的炎症代谢特征
Stefano Cacciatore,Martha Wium,Cristina Licari et al.
Stefano Cacciatore et al.
Background: Men with African ancestry are more likely to develop aggressive prostate cancer (PCa) and to die from this disease. The study of PCa in the South African population represents an opportunity for biomedical res...
The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer [0.03%]
非小细胞肺癌中癌细胞和肿瘤基质中的精氨琥珀酸合成酶1（ASS1）和精氨酸酶-2（ARG2）表达模式的预后及治疗意义
Alexandra Giatromanolaki,Adrian L Harris,Michael I Koukourakis
Alexandra Giatromanolaki
Background: Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response. ...
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma [0.03%]
丙酮酸羧化酶功能障碍是胶质瘤糖酵解抑制毒性的主要因素
Sunada Khadka,Kenisha Arthur,Yasaman Barekatain et al.
Sunada Khadka et al.
Background: Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) ...
Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma [0.03%]
非小细胞肺癌中L-[苯环~(13)C_6]苯丙氨酸和酪氨酸动力学的质谱成像研究
Jianhua Cao,Benjamin Balluff,Martijn Arts et al.
Jianhua Cao et al.
Background: Metabolic reprogramming is a common phenomenon in tumorigenesis and tumor progression. Amino acids are important mediators in cancer metabolism, and their kinetics in tumor tissue are far from being understood...
The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study [0.03%]
代谢综合征对头颈肿瘤发病风险的影响：基于人口的前瞻性队列研究
Huaili Jiang,Lei Zhou,Qiangsheng He et al.
Huaili Jiang et al.
Background: There are limited evidences clarifying the impact of metabolic syndrome (MS) and its components on head and neck cancer (HNC) incidence risk. We explored the correlation between MS, MS components, and the comb...
Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells [0.03%]
抑制糖酵解和线粒体呼吸可促进神经母细胞瘤和胶质瘤细胞的放射敏感性增强
Donna L Nile,Colin Rae,David J Walker et al.
Donna L Nile et al.
Background: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, t...
Lipopolysaccharide promotes metastasis via acceleration of glycolysis by the nuclear factor-κB/snail/hexokinase3 signaling axis in colorectal cancer [0.03%]
脂多糖通过核因子-κB/snail/己糖激酶3信号轴加速糖酵解促进结直肠癌转移
Xuesong Wu,Senmi Qian,Jun Zhang et al.
Xuesong Wu et al.
Background: Cancer cell is generally characterized by enhanced glycolysis. Inflammasome activation is interaction with glycolysis. The concentration of lipopolysaccharide (LPS), a classic inflammasome activator, is signif...
Yue Zhou,Lei Tao,Xia Zhou et al.
Yue Zhou et al.
Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the non-neoplastic diseases involvi...
High-resolution spatiotemporal pHe and pO2 imaging in head and neck and oesophageal carcinoma cells [0.03%]
头颈和食道癌细胞中高分辨率的空间和时间pHe和pO2成像技术
Alexandra Blancke Soares,Robert Meier,Gregor Liebsch et al.
Alexandra Blancke Soares et al.
Background: pO2 and pH are physiological parameters relevant for different processes in health and disease, including wound healing and cancer progression. Head and neck squamous cell carcinomas (HNSCC) and oesophageal sq...