ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism [0.03%]
ASS1和ASL通过改变氮代谢在透明细胞肾细胞癌中抑制生长
Sanika Khare,Laura C Kim,Graham Lobel et al.
Sanika Khare et al.
Background: Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes. Urea metabolism is on...
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth [0.03%]
正位胰腺肿瘤生长需要动态调节线粒体丙酮酸代谢
Nancy P Echeverri Ruiz,Vijay Mohan,Jinghai Wu et al.
Nancy P Echeverri Ruiz et al.
Background: Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogena...
Detection of glucose-derived D- and L-lactate in cancer cells by the use of a chiral NMR shift reagent [0.03%]
手性NMR移位试剂在癌细胞中检测来自葡萄糖的D-和L-乳酸
Eul Hyun Suh,Carlos F G C Geraldes,Sara Chirayil et al.
Eul Hyun Suh et al.
Background: Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to L-lactate. Although D-lactate can also be produced from glucose via the met...
3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation [0.03%]
3-溴丙酮酸介导的MCT1依赖的代谢扰动使三阴性乳腺癌细胞对电离辐射敏感化
Irini Skaripa-Koukelli,David Hauton,John Walsby-Tickle et al.
Irini Skaripa-Koukelli et al.
Background: Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) gene amplificat...
Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15 [0.03%]
线粒体靶向的呋咱并[3,4-b]吡嗪BAM15抑制乳腺癌的增长和增殖
Elizabeth R M Zunica,Christopher L Axelrod,Eunhan Cho et al.
Elizabeth R M Zunica et al.
Background: Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We ha...
mGWAS identification of six novel single nucleotide polymorphism loci with strong correlation to gastric cancer [0.03%]
mGWAS识别出六个与胃癌强相关的新型单核苷酸多态性位点
Shuangfeng Yang,Yuan-Liang Wang,Yanping Lyu et al.
Shuangfeng Yang et al.
Background: Metabolite genome-wide association studies (mGWAS) are key for understanding the genetic regulation of metabolites in complex diseases including cancers. Although mGWAS has revealed hundreds of metabolomics qu...
Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines [0.03%]
来自34,494份患者相关样本和细胞系的癌症稳健代谢转录组分
V C Leeuwenburgh,C G Urzúa-Traslaviña,A Bhattacharya et al.
V C Leeuwenburgh et al.
Background: Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern...
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer [0.03%]
针对小细胞肺癌中MYC增强的糖酵解进行治疗
Kasey R Cargill,C Allison Stewart,Elizabeth M Park et al.
Kasey R Cargill et al.
Introduction: The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respir...
Brief report: The uricase mutation in humans increases our risk for cancer growth [0.03%]
简报：人类的尿酸酶突变会增加我们患癌症的风险
Mehdi A Fini,Miguel A Lanaspa,Eric A Gaucher et al.
Mehdi A Fini et al.
Background: Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to...
Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies [0.03%]
RAS、BCR-ABL和MYC驱动的淋巴样肿瘤在脂质合成代谢中的收敛性
Daniel F Liefwalker,Meital Ryan,Zhichao Wang et al.
Daniel F Liefwalker et al.
Background: Metabolic reprogramming is a central feature in many cancer subtypes and a hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabo...