Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines [0.03%]
三维球体代谢流分析揭示了与匹配的二维培养物中结直肠癌和胰腺导管腺癌细胞系中的葡萄糖代谢具有显著差异
Tia R Tidwell,Gro V Røsland,Karl Johan Tronstad et al.
Tia R Tidwell et al.
Background: Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the tran...
An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells [0.03%]
以去铁敏和乳酸排泄抑制剂为基础的螯合药物抗肿瘤复合疗法可抑制癌细胞增殖
Koichi Fujisawa,Taro Takami,Toshihiko Matsumoto et al.
Koichi Fujisawa et al.
Background: Although iron chelation has garnered attention as a novel therapeutic strategy for cancer, higher levels of efficacy need to be achieved. In the present study, we examined the combinatorial effect of deferoxam...
Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish [0.03%]
斑马鱼肝细胞癌xmrk和myc诱导模型中新型脂质生物标志物的鉴定
Jerry D Monroe,Daniel Fraher,Xiaoqian Huang et al.
Jerry D Monroe et al.
Background: Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is accompanied by complex dysregulation of lipids. Increasing evidence suggests that particular lipid species are associated with HCC ...
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas [0.03%]
HMGCoA还原酶和线粒体复合物I联合抑制诱导BRAF抑制剂耐药黑色素瘤的消退
Evelyn de Groot,Sruthy Varghese,Lin Tan et al.
Evelyn de Groot et al.
Background: Primary and posttreatment resistance to BRAFV600 mutation-targeting inhibitors leads to disease relapse in a majority of melanoma patients. In many instances, this resistance is promoted by upregulation of mit...
Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics [0.03%]
单细胞转录组揭示高胰岛素血症对胰腺癌发生及免疫微环境的影响
Anni M Y Zhang,Ken H Chu,Brian F Daly et al.
Anni M Y Zhang et al.
Background: Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic...
Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells [0.03%]
超生理GLP1受体信号通过GCGR可降低肝癌细胞活力而不刺激糖异生基因表达
Jason Godfrey,Romain Riscal,Nicolas Skuli et al.
Jason Godfrey et al.
Background: Deregulated glucose metabolism is a critical component of cancer growth and survival, clinically evident via FDG-PET imaging of enhanced glucose uptake in tumor nodules. Tumor cells utilize glucose in a variet...
Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX [0.03%]
针对碳酸酐酶IX两种不同细胞外区的新型人源化单克隆抗体以靶向低氧人类肿瘤
Miriam Zatovicova,Ivana Kajanova,Monika Barathova et al.
Miriam Zatovicova et al.
Background: Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be succ...
MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation [0.03%]
微小核糖核酸-377-3p通过负向调节肉碱棕榈酰转移酶1C介导的脂肪酸氧化抑制肝癌细胞生长和转移
Ting Zhang,Yanan Zhang,Jie Liu et al.
Ting Zhang et al.
Background: Altered lipid metabolism is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) is a member of CPT1 family and plays a key role in can...
Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover [0.03%]
低密度脂蛋白胆固醇的可用性和胆固醇酯周转影响前列腺癌细胞增殖
Nikki L Raftopulos,Tinashe C Washaya,Andreas Niederprüm et al.
Nikki L Raftopulos et al.
Background: Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However, prostate cancer cells inevitably adapt, resulting in di...
Daniela Šimčíková,Dominik Gardáš,Kateřina Hložková et al.
Daniela Šimčíková et al.
Background: Hexokinases (HKs) are well-studied enzymes catalyzing the first step of glycolysis. However, non-canonical regulatory roles of HKs are still incompletely understood. Here, we hypothesized that HKs comprise one...