Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study [0.03%]
计算机体层摄影测定机体组成和直肠癌患者的生存率：一项瑞典队列研究
Angeliki Kotti,Annica Holmqvist,Mischa Woisetschläger et al.
Angeliki Kotti et al.
Background: The association between body composition and survival in rectal cancer patients is still unclear. Therefore, we aimed to evaluate the impact of computed tomography (CT)-measured body composition on survival in...
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of L-type amino acid transporter 1 [0.03%]
磷酸蛋白质组学揭示了由抑制L型氨基酸转运蛋白1诱导的癌症氨基酸稳态紊乱立即响应的细胞信号
Hiroki Okanishi,Ryuichi Ohgaki,Minhui Xu et al.
Hiroki Okanishi et al.
Background: Cancer-upregulated L-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling...
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment [0.03%]
肥胖肺微环境中改变的乙酰辅酶A代谢呈现新的潜在免疫治疗靶点
Spencer R Rosario,Randall J Smith Jr,Santosh K Patnaik et al.
Spencer R Rosario et al.
Contrary to the "obesity paradox," which arises from retrospective studies relying on body mass index to define obesity, epidemiologic evidence suggests central or visceral obesity is associated with a higher risk for the development of lun...
Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls [0.03%]
基于数据的血浆代谢物聚类及具有潜在早期发现肺癌病例的个体代谢物鉴定
Julian O Kim,Robert Balshaw,Connel Trevena et al.
Julian O Kim et al.
Background: Metabolomics is a potential means for biofluid-based lung cancer detection. We conducted a non-targeted, data-driven assessment of plasma from early-stage non-small cell lung cancer (ES-NSCLC) cases versus can...
Rachana Bhatt,Dashnamoorthy Ravi,Andrew M Evens et al.
Rachana Bhatt et al.
Background: Diffuse large B cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and accounts for about a third of all NHL cases. A significant proportion (~40%) of treated DLBCL patients develop r...
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma [0.03%]
ACSL3调节透明细胞肾细胞癌中的脂滴生物发生和铁死亡敏感性
Timothy D Klasson,Edward L LaGory,Hongjuan Zhao et al.
Timothy D Klasson et al.
Background: Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. H...
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer [0.03%]
血浆代谢组和蛋白质组联合分析揭示乳腺癌的代谢特征
Rui An,Haitao Yu,Yanzhong Wang et al.
Rui An et al.
Background: Breast cancer (BC) is the most commonly diagnosed cancer. Currently, mammography and breast ultrasonography are the main clinical screening methods for BC. Our study aimed to reveal the specific metabolic prof...
Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity [0.03%]
生酮饮食能在体内减缓黑色素瘤生长且与肿瘤的遗传学和代谢可塑性无关
Daniela D Weber,Sepideh Aminzadeh-Gohari,Maheshwor Thapa et al.
Daniela D Weber et al.
Background: Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear which genetic, metabolic, or immunological factors contribute to the benef...
13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo [0.03%]
13C示踪分析表明体内内源性CO2的循环范围很广
Likun Duan,Daniel E Cooper,Grace Scheidemantle et al.
Likun Duan et al.
Background: 13C tracer analysis is increasingly used to monitor cellular metabolism in vivo and in intact cells, but data interpretation is still the key element to unveil the complexity of metabolic activities. The disti...
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress [0.03%]
伊立替康诱导的DNA复制压力下结直肠癌细胞代谢改变全局特征
Christian Marx,Jürgen Sonnemann,Oliver D K Maddocks et al.
Christian Marx et al.
Background: Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms t...