Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia [0.03%]
肝ChREBP活性正常化不能阻止I型肝糖原贮积病小鼠模型中肝脏疾病的发展
Martijn G S Rutten,Yu Lei,Joanne H Hoogerland et al.
Martijn G S Rutten et al.
Background: Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cance...
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells [0.03%]
乳腺癌细胞偏向转移至肺或骨的乳腺癌细胞比母体MDA-MB-231细胞更倾向于糖酵解，合成丝氨酸的速度更快，并且消耗较少的ATP和NADPH
Mika B Jekabsons,Mollie Merrell,Anna G Skubiz et al.
Mika B Jekabsons et al.
Gene expression signatures associated with breast cancer metastases suggest that metabolic re-wiring is important for metastatic growth in lungs, bones, and other organs. However, since pathway fluxes depend on additional factors such as AT...
Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer [0.03%]
他莫昔芬通过NRF2介导的代谢重组在乳腺癌中诱导放射耐药性
F V Reinema,F C G J Sweep,G J Adema et al.
F V Reinema et al.
Background: Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we investigated the mechanisms associated with tamoxifen-induced radioresistance, aiming to ...
Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia [0.03%]
代谢谱分析揭示儿童急性淋巴细胞白血病巩固治疗的代谢特征
Jinqiu Fu,Aijun Zhang,Qinqin Liu et al.
Jinqiu Fu et al.
Acute lymphoblastic leukemia (ALL) and its treatment continue to pose substantial risks. To understand ALL more deeply, the metabolome in fasting plasma of 27 ALL patients before and after high-dose methotrexate therapies (consolidation the...
Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells [0.03%]
精氨酸酶-1的抑制可降低结肠癌细胞的转移能力和转移种植能力
Xiangdong Wang,Huihui Xiang,Yujiro Toyoshima et al.
Xiangdong Wang et al.
Background: Arginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of arginine to urea and ornithine, which regulates the proliferation, differentiation, and function of various cells. However, it is unc...
Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma [0.03%]
糖酵解型胰腺导管腺癌的功能无创探测
Irina Heid,Corinna Münch,Sinan Karakaya et al.
Irina Heid et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based disti...
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer [0.03%]
PDK1和PDK2介导的代谢重塑促进TGFβ1在头颈癌中增强干性特性
Wan-Hsuan Sun,Yun-Hsuan Chen,Hou-Hsuan Lee et al.
Wan-Hsuan Sun et al.
Background: Resistance to chemotherapeutic drugs is a key factor for cancer recurrence and metastases in head and neck cancer (HNC). Cancer stem cells (CSCs) in tumors have self-renewal, differentiation, and higher drug r...
Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer [0.03%]
他达拉非通过抑制PRMT5介导的结直肠癌糖酵解和细胞增殖来提高5-FU的抗肿瘤活性
Yao Shen,Pan Zhao,Kewei Dong et al.
Yao Shen et al.
Background: Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation. However, the role of PRMT5 in colorectal cancer remains poorly understood. ...
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity [0.03%]
同位素示踪显示具有不同抗肿瘤免疫性的小鼠黑素瘤亚型底物偏好性不同
Xinyi Zhang,Alexandra A Halberstam,Wanling Zhu et al.
Xinyi Zhang et al.
Background: Research about tumor "metabolic flexibility"-the ability of cells to toggle between preferred nutrients depending on the metabolic context-has largely focused on obesity-associated cancers. However, increasing...
Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism [0.03%]
通过靶向miR-506-3p-PTBP1介导的葡萄糖代谢，阻断长非编码RNA-SNHG16使胃癌细胞对5-Fu敏感
Yan Ding,Sujie Gao,Jiabin Zheng et al.
Yan Ding et al.
Background: Gastric cancer (GC) is a commonly occurring human malignancy. The 5-fluorouracil (5-Fu) is a first-line anti-gastric cancer agent. However, a large number of GC patients developed 5-Fu resistance. Currently, t...