Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells [0.03%]
胆固醇重新编程葡萄糖和脂质代谢以促进结直肠癌细胞增殖
Shyamananda Singh Mayengbam,Abhijeet Singh,Himanshi Yaduvanshi et al.
Shyamananda Singh Mayengbam et al.
Hypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the role of increased circulatory ch...
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo [0.03%]
实时活体体内能量压力的正电子发射断层显像检查钠碘转运蛋白 sourceMapping：该句子的主要内容涉及医学影像学和生物学领域，具体来说是关于“钠碘转运蛋白”（Sodium Iodide Symporter, NIS）在检测生物体内实时能量压力方面的应用。NIS是一种重要的膜蛋白，通常存在于甲状腺中，但也被发现在其他组织和细胞类型中有表达，可用于非侵入性成像技术如正电子发射断层扫描(PET)来监测生理或病理过程中的碘摄取与代谢情况。
翻译时需注意以下几点：
- “Positron emission tomography”（正电子发射断层显像）简称PET。
- “sodium iodide
Piotr Dzien,Agata Mackintosh,Gaurav Malviya et al.
Piotr Dzien et al.
Background: Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic tr...
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states [0.03%]
比较极性和脂质血浆代谢组学区分KSHV感染和疾病状态
Sara R Privatt,Camila Pereira Braga,Alicia Johnson et al.
Sara R Privatt et al.
Background: Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either...
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells [0.03%]
磁小体细菌诱导人类乳腺癌细胞凋亡路径
Stefano Menghini,Matej Vizovisek,Jonathas Enders et al.
Stefano Menghini et al.
The use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings of conventional treatments. The ability of anaerobic bacteria to preferentially accumulate and replicate in hypoxic regions of solid tumors, as a cons...
Restoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma [0.03%]
TEF通过恢复糖异生抑制肾透明细胞癌的增殖并促进其凋亡和免疫监视
Wenyuan Zhuang,Xiaokai Shi,Shenglin Gao et al.
Wenyuan Zhuang et al.
Background: Kidney renal clear cell carcinoma (KIRC) is the major histological subtype of kidney tumor which covers approximately 80% of the cases. Although various therapies have been developed, the clinical outcome rema...
Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells [0.03%]
长链非编码RNA CCHE1通过调节LDHA介导的糖酵解作用赋予黑色素瘤细胞化学抗性
Zhi Ding,Junyi Yang,Baojin Wu et al.
Zhi Ding et al.
Melanoma is considered as the most common metastatic skin cancer with increasing incidence and high mortality globally. The vital roles of long non-coding RNAs (lncRNAs) in the tumorigenesis of melanoma are elucidated by emerging evidence. ...
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells [0.03%]
BMP4通过SMAD/SLC2A1（GLUT1）信号轴上调肝癌细胞糖原合成的水平
Jiamin Zhong,Luyao Tian,Yannian Gou et al.
Jiamin Zhong et al.
Background: Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and ...
Obesity and breast cancer prognosis: pre-diagnostic anthropometric measures in relation to patient, tumor, and treatment characteristics [0.03%]
肥胖与乳腺癌预后：前瞻性诊断人体测量指标与患者、肿瘤和治疗特征的关系
Sixten Harborg,Maria Feldt,Deirdre Cronin-Fenton et al.
Sixten Harborg et al.
Purpose: Examine the association between obesity and clinical outcomes in early breast cancer and assess if patient, tumor, and treatment characteristics modify such associations in Malmö Diet and Cancer Study patients (...
Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer [0.03%]
IDO1/TDO2双重抑制增强铂类耐药非小细胞肺癌抗肿瘤免疫能力
Chunjing Wu,Sydney A Spector,George Theodoropoulos et al.
Chunjing Wu et al.
Background: The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-...
Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study [0.03%]
达格列净联合标准化疗治疗晚期不可手术胰腺导管腺癌患者的安全性、耐受性和疗效：一项1b期观察性研究
Lauren K Park,Kian-Huat Lim,Jonas Volkman et al.
Lauren K Park et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Thus, there is an urgent need for safe and effective novel therapies. PDAC's excessive reliance on glucose metabolism for its metabolic needs pro...