A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells [0.03%]
HIF-1α抑制剂联合棕榈酸和左旋肉碱处理可防止缺氧下的脂肪代谢重编程并诱导肝癌细胞凋亡
Shohei Matsufuji,Yoshihiko Kitajima,Kazuki Higure et al.
Shohei Matsufuji et al.
Background: A hypoxic environment often persists within solid tumors, including hepatocellular carcinoma (HCC). Hypoxia-inducible factor-1α (HIF-1α) can accelerate cancer malignancy by inducing hypoxia-dependent express...
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin's lymphoma-an observational study [0.03%]
基于代谢状态的肥胖分类重新定义了非霍奇金淋巴瘤的再入院率——一项观察性研究
Hang Dong,Honglin Guo,Jing Du et al.
Hang Dong et al.
Background: The relationship between obesity and non-Hodgkin's lymphoma (NHL) was controversial, which may be due to the crudeness definition of obesity based on body mass index (BMI). As obesity and metabolic abnormaliti...
Metabolic changes preceding bladder cancer occurrence among Korean men: a nested case-control study from the KCPS-II cohort [0.03%]
基于韩国人队列的巢式病例对照研究发现： precedings bladder cancer occurrence metabolic changes
Youngmin Han,Unchong Kim,Keum Ji Jung et al.
Youngmin Han et al.
Background: Bladder cancer (BLCA) research in Koreans is still lacking, especially in focusing on the prediction of BLCA. The current study aimed to discover metabolic signatures related to BLCA onset and confirm its pote...
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages [0.03%]
细胞因子活化经典小胶质细胞/M1型巨噬细胞的内源性代谢辅因子 autofluorescence 成像研究
Shelby N Bess,Matthew J Igoe,Abby C Denison et al.
Shelby N Bess et al.
Background: Macrophages are one of the most prevalent subsets of immune cells within the tumor microenvironment and perform a range of functions depending on the cytokines and chemokines released by surrounding cells and ...
The effects of chemotherapy on resting energy expenditure, body composition, and cancer-related fatigue in women with breast cancer: a prospective cohort study [0.03%]
化疗对乳腺癌患者静息能量消耗、身体组成和癌症相关疲劳的影响：前瞻性队列研究
Timia Van Soom,Wiebren Tjalma,Konstantinos Papadimitriou et al.
Timia Van Soom et al.
Background: Breast cancer (BC) is the most prevalent tumor in women. Improvements in treatment led to declined mortality, resulting in more survivors living with cancer- or therapy-induced comorbidities. In this study, we...
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors [0.03%]
ATM抑制作用可阻断葡萄糖代谢并增强耐药性肺癌细胞系对致癌信号驱动抑制剂的敏感性
Cristina Terlizzi,Viviana De Rosa,Francesca Iommelli et al.
Cristina Terlizzi et al.
Background: ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress re...
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells [0.03%]
胆固醇通过重新编程葡萄糖和脂质代谢来促进结直肠癌细胞增殖的校正通知文章
Shyamananda Singh Mayengbam,Abhijeet Singh,Himanshi Yaduvanshi et al.
Shyamananda Singh Mayengbam et al.
Published Erratum
Cancer & metabolism. 2023 Oct 26;11(1):19. DOI:10.1186/s40170-023-00321-3 2023
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition [0.03%]
阿司匹林重组结直肠癌细胞代谢并使其对谷氨酰胺酶抑制敏感
Amy K Holt,Arafath K Najumudeen,Tracey J Collard et al.
Amy K Holt et al.
Background: To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However...
Untargeted plasma metabolomics and risk of colorectal cancer-an analysis nested within a large-scale prospective cohort [0.03%]
基于大规模前瞻性队列的血浆非靶向代谢组与结直肠癌风险分析研究
Linda Vidman,Rui Zheng,Stina Bodén et al.
Linda Vidman et al.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, but if discovered at an early stage, the survival rate is high. The aim of this study was to identify novel markers predictive of f...
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling [0.03%]
基于血浆代谢组谱鉴定子宫内膜癌诊断及疗效监测的预测性生物标志物
Eiji Hishinuma,Muneaki Shimada,Naomi Matsukawa et al.
Eiji Hishinuma et al.
Background: Endometrial cancer (EMC) is the most common female genital tract malignancy with an increasing prevalence in many countries including Japan, a fact that renders early detection and treatment necessary to prote...