Mohammad Nemati,Mehdi Shayanfar,Fatemeh Almasi et al.
Mohammad Nemati et al.
Although the association of individual foods and nutrients with glioma have been investigated, studies on the association of major dietary patterns and glioma are scarce. The aim of this study was to examine the association between major di...
Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc-ODC1 nexus [0.03%]
HIGD1A的高表达通过c-Myc-ODC1连接调节聚胺代谢推动肝细胞癌进展
Haixing Zhang,Xiaoran Li,Ziying Liu et al.
Haixing Zhang et al.
Background: Hypoxia contributes to cancer progression through various molecular mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies. Hypoxia-inducible gene domain protein-1a (HIGD1A) is t...
Dameng Li,Xueying Zhou,Wenxian Xu et al.
Dameng Li et al.
Background: Metastasis is the leading cause of death among prostate cancer (PCa) patients. Obesity is associated with both PCa-specific and all-cause mortality. High-fat diet (HFD) is a risk factor contributing to obesity...
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response [0.03%]
锥光受体磷酸二酯酶PDE6H的抑制调节癌细胞生长和代谢，复制黑暗视网膜反应
Ceren Yalaz,Esther Bridges,Nasullah K Alham et al.
Ceren Yalaz et al.
Background: PDE6H encodes PDE6γ', the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cG...
Tiina A Jokela,Jari E Karppinen,Minta Kärkkäinen et al.
Tiina A Jokela et al.
Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Ly...
Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia [0.03%]
系统性炎症和与胰岛素抵抗相关的指标可预测癌症恶病质患者预后不良
Guo-Tian Ruan,Li Deng,Hai-Lun Xie et al.
Guo-Tian Ruan et al.
Background: The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...
Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer [0.03%]
TOP1MT的缺乏通过刺激胃癌中PDK4的表达增强糖酵解过程
Hongqiang Wang,Xutao Sun,Chen Yang et al.
Hongqiang Wang et al.
Background: Abnormal glucose metabolism is one of the determinants of maintaining malignant characteristics of cancer. Targeting cancer metabolism is regarded as a new strategy for cancer treatment. Our previous studies h...
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer [0.03%]
胃肠道癌症患者脂肪组织中脂解生物标志物的评估
Federica Tambaro,Giovanni Imbimbo,Elisabetta Ferraro et al.
Federica Tambaro et al.
Background: Adipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described in cancer-promoting adipose tissue atrophy. For this reason, we assessed the expression of th...
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma [0.03%]
STEAP4通过抑制PI3K/AKT信号途径逆转肝癌细胞顺铂耐药性
Binhui Xie,Baiyin Zhong,Zhenxian Zhao et al.
Binhui Xie et al.
Chemotherapy resistance is the leading cause for hepatocellular carcinoma (HCC)-induced death. Exploring resistance generation mechanism is an urgent need for HCC therapy. Here, we found STEAP4 was significantly downregulated in HCC patient...
A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC [0.03%]
一个反馈环路PPP/PI3K/AKT信号通路驱动的regorafenib耐药在肝细胞癌中
Huihua Yang,Dahong Chen,Yafei Wu et al.
Huihua Yang et al.
Background: Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC. However, ...