Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases [0.03%]
硫酸脂质成像可识别结直肠癌腹膜转移瘤中的肿瘤细胞
G M Sarcinelli,L Varinelli,S Ghislanzoni et al.
G M Sarcinelli et al.
Even with systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC), peritoneal metastases (PM) remain a common site of disease progression for colorectal cancer (CRC) and are frequently assoc...
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes [0.03%]
糖代谢状态、胰岛素抵抗与糖尿病患者和非糖尿病患者的肺癌死亡率关系研究
In Young Cho,Yoosoo Chang,Eunju Sung et al.
In Young Cho et al.
Background: The effects of glycemic status and insulin resistance on lung cancer remain unclear. We investigated the associations between both glycemic status and insulin resistance, and lung cancer mortality, in a young ...
Metabolic alterations and cellular responses to β-Hydroxybutyrate treatment in breast cancer cells [0.03%]
β-羟基丁酸盐处理对乳腺癌细胞的代谢改变和细胞反应的影响
Hadas Fulman-Levy,Raichel Cohen-Harazi,Bar Levi et al.
Hadas Fulman-Levy et al.
Background: The ketogenic diet (KD), based on high fat (over 70% of daily calories), low carbohydrate, and adequate protein intake, has become popular due to its potential therapeutic benefits for several diseases includi...
Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo [0.03%]
离体和在体内扰乱乳腺癌细胞的Na+离子稳态和Na+/K+ATP酶活性可直接调节糖酵解作用
Aidan M Michaels,Anna Zoccarato,Zoe Hoare et al.
Aidan M Michaels et al.
Background: Glycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine triphosphate (ATP), however it is unknown what th...
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer [0.03%]
缺氧诱导的NOS1作为高胆固醇相关结直肠癌的治疗靶点
Weiqing Qiu,Li Zhao,Hua Liu et al.
Weiqing Qiu et al.
Background: It is well established that hypercholesterolemia increases the risk of atherosclerosis, especially because it reduces the availability of nitric oxide (NO). However, the relationship between hypercholesterolem...
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging [0.03%]
基于高通量活细胞成像的OXPHOS抑制剂介导的缺氧改善的作用特征
Anne P M Beerkens,Daan F Boreel,James A Nathan et al.
Anne P M Beerkens et al.
Background: Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to ...
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus [0.03%]
他汀类药物在二甲双胍与2型糖尿病女性乳腺癌风险关联中的调节作用
Fan Zhang,Geertruida H de Bock,Gijs W Landman et al.
Fan Zhang et al.
Introduction: Metformin and statins are considered as potential agents for prevention of breast cancer, however, existing evidence does not uniformly substantiate this claim, and the data is scarce concerning their intera...
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma [0.03%]
嘌呤补救促进H3K27M突变弥漫内生性桥脑胶质瘤的治疗抵抗作用
Erik R Peterson,Peter Sajjakulnukit,Andrew J Scott et al.
Erik R Peterson et al.
Background: Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine...
BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria [0.03%]
胰腺癌中的BCAA代谢通过调节脂肪酸进入线粒体影响脂质平衡
Klára Gotvaldová,Jitka Špačková,Jiří Novotný et al.
Klára Gotvaldová et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the implications for the role of BCAA metabolism in PDAC development or p...
Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells [0.03%]
肺癌和原发性支气管上皮细胞在饥饿状态下合成和分解丝氨酸的能力不同
Theresa Haitzmann,Katharina Schindlmaier,Tobias Frech et al.
Theresa Haitzmann et al.
Serine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from the extracellular space. In lung cancer, serine synthesis gene expression is variable, yet, e...