Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles [0.03%]
胰腺癌肿瘤类器官表现出代谢谱的亚型特异性差异
Hassan A Ali,Joanna M Karasinska,James T Topham et al.
Hassan A Ali et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-bas...
Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability [0.03%]
卵巢初级高级别浆液性卵巢癌细胞在限谷氨酰胺或葡萄糖条件下的代谢特征分析
Daniela Šimčíková,Dominik Gardáš,Tomáš Pelikán et al.
Daniela Šimčíková et al.
Background: High-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian carcinoma. It is primarily diagnosed at stage III or IV when the 5-year survival rate ranges between ...
PAF1/HIF1α axis rewires the glycolytic metabolism to fuel aggressiveness of pancreatic cancer [0.03%]
PAF1/HIF1α轴重新布线糖酵解代谢以促进胰腺癌的恶性进展
Ayoola O Ogunleye,Neelanjana Gayen,Sanchita Rauth et al.
Ayoola O Ogunleye et al.
Background: PAF1/PD2 deregulation contributes to tumorigenesis, drug resistance, and cancer stem cell maintenance in Pancreatic Cancer (PC). Recent studies demonstrate that metabolic reprogramming plays a role in PC progr...
Real-time assessment of relative mitochondrial ATP synthesis response against inhibiting and stimulating substrates (MitoRAISE) [0.03%]
线粒体实时阿特匹兹反应评估法(MitoRAISE)
Eun Sol Chang,Kyoung Song,Ji-Young Song et al.
Eun Sol Chang et al.
Background: Mitochondria are known to synthesize adenosine triphosphate (ATP) through oxidative phosphorylation. Understanding and accurately measuring mitochondrial ATP synthesis rate can provide insights into the functi...
The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells [0.03%]
多不饱和脂肪酸-docosahexaenoic影响前列腺癌细胞的线粒体功能
Guilherme Henrique Tamarindo,Caroline Fidalgo Ribeiro,Alana Della Torre Silva et al.
Guilherme Henrique Tamarindo et al.
Background: Prostate cancer (PCa) shows a rewired metabolism featuring increased fatty acid uptake and synthesis via de novo lipogenesis, both sharply related to mitochondrial physiology. The docosahexaenoic acid (DHA) is...
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT [0.03%]
表观遗传抑制新的半胱氨酸合酶通过上调胱氨酸摄取转运蛋白xCT诱导肝癌细胞内半胱氨酸聚集
Tomoaki Yamauchi,Yumi Okano,Daishu Terada et al.
Tomoaki Yamauchi et al.
Background: The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation of cysteine is often observed in various cancers, suggesting its potential role i...
METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer [0.03%]
METTL16通过m6A修饰调控FBXO5的mRNA稳定性以促进乳腺癌恶性行为
Runying Wang,Xingjie Gao,Luhan Xie et al.
Runying Wang et al.
Background: N6-methyladenosine (m6A) regulates the progression of breast cancer (BC). We aimed to investigate the action and mechanism involved of methyltransferase-like protein 16 (METTL16) in BC growth and metastasis. ...
The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients [0.03%]
癌周组织反应性侵袭边界面积(SARIFA)与瓦博格分型及生存期的关系：一项大样本前瞻性结直肠癌患者的分析结果
Kelly Offermans,Nic G Reitsam,Colinda C J M Simons et al.
Kelly Offermans et al.
Background: Stroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in gastrointestinal cancers, including colorectal cancer (CRC), defined as dire...
Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species [0.03%]
亚临床剂量照射通过线粒体活性氧触发人乳腺癌迁移
Justin D Rondeau,Justine A Van de Velde,Yasmine Bouidida et al.
Justin D Rondeau et al.
Background: Despite technological advances in radiotherapy, cancer cells at the tumor margin and in diffusive infiltrates can receive subcytotoxic doses of photons. Even if only a minority of cancer cells are concerned, p...
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma [0.03%]
长效欧文氏菌（Erwinia chrysanthemi）Pegcrisantaspase在胰腺导管腺癌临床前模型中诱导替代氨基酸生物合成途径
Dominique Bollino,Kanwal Hameed,Anusha Bhat et al.
Dominique Bollino et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC metabolism through amino acid restriction has emerged as...