Intra-individual fluctuations in alkaline phosphatase predict mortality and CKD progression: insights from a large CKD cohort [0.03%]
同一患者碱性磷酸酶的波动与死亡率和慢性肾脏病进展相关：来自大规模CKD队列的见解
Yaerim Kim,Ping-Hsun Wu,Soie Kwon et al.
Yaerim Kim et al.
Background: Elevated alkaline phosphatase (ALP) levels are associated with mortality. However, the significance of ALP variability, particularly in chronic kidney disease (CKD), has not been well explored. This study exam...
Impact of dapagliflozin on bone mineral metabolism in non-diabetic patients with chronic kidney disease: a randomized, double-blind, placebo-controlled study [0.03%]
达格列净对非糖尿病慢性肾脏病患者骨矿代谢的影响：随机、双盲、安慰剂对照研究
Mohamed Elshayeb,Ahmed Abdulgalil,Amr El-Husseini et al.
Mohamed Elshayeb et al.
Background: Sodium-glucose co-transporter 2 inhibitors have demonstrated renoprotective effects in patients with CKD. However, concerns remain regarding their potential effect on bone mineral metabolism. This study invest...
Beyond expensive innovations: affordable and effective strategies for managing tubulopathies in adults [0.03%]
超越昂贵的创新：管理成人肾小管疾病的经济且有效的策略
Louise Nielsen,Lucile Figueres
Louise Nielsen
Tubulopathies comprise a heterogeneous and still poorly defined group of inherited and acquired disorders in which tubular transport is disproportionately impaired, resulting in chronic electrolyte and acid-base disturbances with downstream...
Mathias Haarhaus
Mathias Haarhaus
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy [0.03%]
podocytopathy的分子机制：寻找适合靶点以开启-glomerulus基因治疗新时代
Nadia Tavakolidakhrabadi,Wen Y Ding,Gavin I Welsh et al.
Nadia Tavakolidakhrabadi et al.
Podocytopathies encompass a spectrum of glomerular disorders driven by structural and functional impairments in podocytes: specialized cells critical for maintaining the glomerular filtration barrier. Dysregulation of key podocyte component...
Constantina Chrysochou,Alexander Hamilton,Klebert Tembe et al.
Constantina Chrysochou et al.
The transition from paediatric to adult renal care is a challenging time for children and young people (CYP). For them, this is a period of seismic change overall and a key step during their journey from parental support to independence. Im...
Intradialytic exercise: a controlled nationwide effectiveness-implementation study [0.03%]
透析运动：一项全国范围内的实效性实施研究
Pedro M Martins,Diogo V Leal,Aníbal A Ferreira et al.
Pedro M Martins et al.
Background: Efficacy studies have demonstrated the benefits of intradialytic exercise. However, real-world effectiveness trials are lacking. This study evaluated a nationwide clinical implementation of intradialytic exerc...
Intradialytic hypotension is severely underreported by intermittent blood pressure readings [0.03%]
间断血压测量严重低估了透析低血压的发生率
Sabrine Chaara,Muriel P C Grooteman,Menso J Nubé et al.
Sabrine Chaara et al.
Background: Intradialytic hypotension (IDH) has been associated with both morbidity and mortality. Yet, as IDH often occurs asymptomatic, it might be easily missed with routine twice per hour brachial artery cuff-blood pr...
Unravelling sex-specific differences in autosomal dominant polycystic kidney disease: a multiorgan perspective [0.03%]
从多器官角度解析常染色体显性遗传多囊肾病的性别差异
Mónica Furlano,Adria Tinoco,Diego Toso et al.
Mónica Furlano et al.
Autosomal dominant polycystic kidney disease (ADPKD) is a complex, multisystemic disorder exhibiting notable sex-related differences in clinical presentation, progression and complications. While the disease affects both sexes, disease expr...
Decommissioning retired hemodialysis machines in Dutch hospitals: strategies and sustainability considerations [0.03%]
荷兰医院透析机下线策略及可持续性问题探讨
Vincent Peters,Niels Verhoeven,Wendy van der Valk et al.
Vincent Peters et al.
Background: The decommissioning of hemodialysis machines, particularly in the context of transitioning from hemodialysis to hemodiafiltration, remains understudied despite its importance for sustainable healthcare. This s...