Safety of Dose 1 of the Nine-Valent Human Papillomavirus Vaccine in Children Aged 4-8 Years [0.03%]
九价人乳头瘤病毒疫苗1剂在4至8岁儿童中的安全性研究
Natalie Pierre-Joseph,Vishakha Sabharwal,Ruchita Borgaonkar et al.
Natalie Pierre-Joseph et al.
Data on the safety of the nine-valent human papillomavirus (9vHPV) vaccine in children younger than 9 years are limited. We conducted a single-center, open-label descriptive safety study of 150 healthy children aged 4-8 years who received d...
Victoria J L Konold,Adam W Brothers,Matthew P Kronman et al.
Victoria J L Konold et al.
Vancomycin is the first line antibiotic for resistant gram-positive infections, but can cause nephrotoxicity, ototoxicity, increased cost and healthcare utilization. We present an honorable memorial to this agent given the availability of s...
BNT162b2 2024-2025 Vaccine Effectiveness against COVID-19 in Children aged 6 months-17 years [0.03%]
6个月至17岁儿童接种BNT162b2新冠疫苗（2024-2025年）的有效性
Sara Y Tartof,Tara Ahi,Timothy B Frankland et al.
Sara Y Tartof et al.
In a test-negative case-control design among children aged 6 months-4 years (n=11,878) and 5-17 years (n=16,687) in Kaiser Permanente Southern California, BNT162b2 2024-2025 effectiveness against hospitalization/emergency department/urgent ...
Andrew S Haynes,Kira E Frappa,Matthew A Miller
Andrew S Haynes
In a satirical response, vancomycin defends its modern relevance by highlighting AUC-guided dosing, predictable pharmacokinetics, durability against resistance, and established clinical scenarios where it remains essential, while challengin...
HIV-Specific vs Universal Immunization Coverage in US Children with HIV: A Multi-Site Study [0.03%]
美国艾滋儿童的艾滋特异免疫和普遍免疫接种覆盖率多中心研究
Samie Sabet,Nicholas Hollman,Amy Hendrix-Dicken et al.
Samie Sabet et al.
Background: Immunization recommendations for children living with HIV (CLWH) differ from the general pediatric population due to increased risk of vaccine-preventable diseases. Adherence to these specific recommendations ...
Early Transition from Parenteral to Oral Antibiotics for Neonates with Bacteremic Urinary Tract Infections [0.03%]
早发性细菌尿路感染的新生儿由静脉注射抗生素向口服抗生素转换的研究
Tara L Greenhow,Kritika Amanjee,Okezi Obrutu et al.
Tara L Greenhow et al.
We conducted a retrospective cohort study of 49 neonates with bacteremic UTIs to assess efficacy of transition to oral antibiotics. Forty-one received oral step-down therapy after parenteral antibiotics; two had relapsed UTIs. No cases of b...
Brain Structure of South African Children Born to Mothers on Dolutegravir versus Efavirenz-Based Antiretroviral Therapy [0.03%]
东非国家出生儿童的母亲基于多替拉韦与依非韦伦的抗逆转录病毒治疗下的孩子大脑结构比较研究
Layla E Bradford,Catherine J Wedderburn,Thokozile R Malaba et al.
Layla E Bradford et al.
Background: The impact of in utero exposure to specific antiretroviral therapy (ART), particularly integrase strand transfer inhibitors, on early brain development remains poorly understood. We used magnetic resonance ima...
Impact of Clinical Decision Support Tools on Antibiotic Prescribing for Pediatric Acute Otitis Media in Emergency and Urgent Care Settings [0.03%]
急诊和门诊临床决策支持工具对儿童急性中耳炎抗生素处方的影响
Joana Dimo,Andrew T Krack,Lori J Silveira et al.
Joana Dimo et al.
Background: Acute otitis media (AOM) is the leading cause of pediatric antibiotic prescribing, often with unnecessarily long treatment durations. This study evaluates the impact of clinical decision support (CDS) tools on...
Safety and Pharmacokinetics of Nirsevimab in Japanese Infants: Primary Analysis of the Open-Label JUBILUS Trial [0.03%]
nirsevimab在日本婴儿中的安全性和药动学：开放标签JUBILUS试验的主要分析结果
Masaaki Mori,Susannah Leach,Maria Learoyd et al.
Masaaki Mori et al.
In Japanese infants aged ≤12 months at risk for severe respiratory syncytial virus-associated lower respiratory tract infections who received two doses of nirsevimab 5-6 months apart, no safety concerns or anti-drug antibodies occurred. Ni...
Early Measles Vaccination in Infants less than 12 Months: Global Practices, Immunity Outcomes, and Implications for Disease Prevention [0.03%]
早接种麻疹疫苗（小于12月龄婴儿）：全球实践、免疫效果及对疾病预防的影响
Amna AlSaihati,Manu Chaudhary,Liset Olarte
Amna AlSaihati
Measles continues to be a global threat that can lead to serious complications, especially in young infants. The World Health Organization recommends a two-dose vaccine series at different timeframes depending on local measles transmission ...