Alterations in sleep-activity cycles and clock gene expression across the synucleinopathy spectrum [0.03%]
多巴胺治疗前后帕金森病患者脑血流量的纵向变化及其与运动功能的相关性
Maria Comas,Xavier Vidal,Oliver Rawashdeh et al.
Maria Comas et al.
A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson's disease cell model [0.03%]
基于基因组的RNA干扰筛选发现SNX5敲低能保护帕金森病细胞模型不受MPP+诱导的毒性损伤
Matthias Höllerhage,Linghan Duan,Oscar Wing Ho Chua et al.
Matthias Höllerhage et al.
Background: Alpha-synuclein (αSyn) is a major player in the pathophysiology of synucleinopathies, which include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. To date, there is no disease-mo...
Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology [0.03%]
人源靶向载shRNA微型环形DNA的外泌体的开发以防止帕金森病理学发展
Maria Izco,Carlos Sola,Martin Schleef et al.
Maria Izco et al.
Background: Neurological disorders are the second leading cause of death and the leading cause of disability in the world. Thus, the development of novel disease-modifying strategies is clearly warranted. We have previous...
Plasma proteomic signatures as predictors of dementia risk in individuals with sleep apnea: a cohort study [0.03%]
针对睡眠呼吸暂停个体的认知障碍风险血浆蛋白质组标志物队列研究
Yufei Liu,Pei-Yang Gao,Zhibo Wang et al.
Yufei Liu et al.
Enhanced serum-based seed amplification assay for detecting propagative α-synuclein seeds in Parkinson's disease [0.03%]
改良的血清基质增强种子扩增法检测帕金森病中传播性α-突触核蛋白种子
Yaoyun Kuang,Hengxu Mao,Wei Dai et al.
Yaoyun Kuang et al.
Isabell Drath,Franziska Richter,Malte Feja
Isabell Drath
There is increasing interest in nose-to-brain delivery as an innovative drug delivery strategy for neurodegenerative disorders such as Parkinson's or Alzheimer's disease. The unique anatomy of the nose-brain interface facilitates direct dru...
Lin Yuan,Li-Hong Mao,Yong-Ye Huang et al.
Lin Yuan et al.
Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid-liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas ce...
Inhibition of SOD1 trimerization is a novel drug target for ALS disease [0.03%]
SOD1三聚体化的抑制是ALS疾病的一个新药物靶点
Tae-Gyun Woo,Jin Han,Yuju Kim et al.
Tae-Gyun Woo et al.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that begins with motor neuron death in the spinal cord and cerebral cortex, ultimately resulting in death from respiratory distres...
Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells [0.03%]
脑内颗粒蛋白前体缺乏：神经元与非神经元细胞间的相互作用
Katarzyna Gaweda-Walerych,Vanessa Aragona,Simona Lodato et al.
Katarzyna Gaweda-Walerych et al.
Heterozygous mutations in GRN gene lead to insufficient levels of the progranulin (PGRN) protein, resulting in frontotemporal dementia (FTD) with TAR DNA-binding protein 43 (TDP-43) inclusions, classified pathologically as frontotemporal lo...
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients [0.03%]
基因治疗在渐冻人症上的突破：给百分之二十的ALS患者带来希望
Qingjian Xie,Kezheng Li,Yinuo Chen et al.
Qingjian Xie et al.
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that remains incurable. Although the etiologies of ALS are diverse and the precise pathogenic mechanisms are not fully understood, approximately 20% of ALS cases are caused...