SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer's disease [0.03%]
人神经嵴来源鼻甲干细胞治疗阿尔茨海默病效果与SSEA3和CD105阳性的关联性研究
Jung Yeon Lim,Jung Eun Lee,Minho Lee et al.
Jung Yeon Lim et al.
Background: Stem cells have the potential to treat Alzheimer's disease (AD), but clinical outcomes are unpredictable due to inter-donor differences in stem cell properties. This study aimed to determine whether the plurip...
Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinson's disease mouse model by modulating gut microbiota dysbiosis and inhibiting the NLRP3 signaling pathway [0.03%]
Bacteroides coprocola通过调节肠道菌群失调和抑制NLRP3信号通路来保护罗滕酮诱导的帕金森病小鼠模型中的多巴胺能神经元
Zixian Liu,Jiabei Nie,Yimei Li et al.
Zixian Liu et al.
Background: Parkinson's disease (PD) is a prevalent neurodegenerative disease and its pathogenesis is still unclear. Emerging evidence supports the gut-origin hypothesis, highlighting gut microbiota dysbiosis as a contrib...
Correction: LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner [0.03%]
校正：LRRK2 G2019S 突变通过 Drp1-STX17 依赖方式贡献于线粒体转移功能障碍
Mei Ding,Fen Wang,Lan-Lan Jiang et al.
Mei Ding et al.
Published Erratum
Translational neurodegeneration. 2026 Feb 14;15(1):6. DOI:10.1186/s40035-025-00533-1 2026
Mitochondrial DNA: a molecular switch driving sterile neuroinflammation [0.03%]
线粒体DNA：驱动无菌神经炎症的分子开关
Abhishek Jauhari,Tanisha Singh,Diane L Carlisle et al.
Abhishek Jauhari et al.
Mitochondrial DNA (mtDNA) plays a pivotal role in the regulation of neuroinflammation, acting as a potent trigger of innate immune responses when released into the cytoplasm or extracellular space. mtDNA is structurally similar to bacterial...
Snigdda Sharma,Alex Vandenakker,Claudia Cortés-Pérez et al.
Snigdda Sharma et al.
Tauopathies are characterized by aberrant tau structure and function, which is associated with neurodegenerative dementias, such as Alzheimer's disease, Pick's disease, and frontotemporal dementia, as well as the motor neuron disease amyotr...
Microbiota and Alzheimer's disease: mechanistic insights from a multi-organ perspective [0.03%]
微生物群与阿尔茨海默病：多器官视角下的机制见解
Jiewen Liao,Hanmeng Mou,Shilin Luo et al.
Jiewen Liao et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder driven by multifactorial mechanisms. Increasing evidence suggests that dysbiosis, a term denoting an imbalance in the composition of the microbiota, may play a pivotal rol...
Mapping cellular vulnerability in Parkinson's disease using retro-AAVs and preformed α-synuclein fibrils [0.03%]
使用逆行腺相关病毒和预形成的α-突触核蛋白原纤维绘制帕金森病的细胞易感性分布图
Fanni F Geibl,Ahmed A S Musa,Leo Dietrich et al.
Fanni F Geibl et al.
Background: Parkinson disease (PD) is characterized by progressive neuronal loss within defined brain regions, accompanied by α-synuclein (αSyn)-rich inclusions, termed Lewy pathology (LP). However, it is unclear which ...
Proximity labeling in neuroscience: decoding molecular landscapes for precision neurology [0.03%]
邻近标记技术在神经科学中的应用：精密神经学分子图谱的解码工具
Xia Gao,Jianjun Lu,Peipei Chen et al.
Xia Gao et al.
The intricate cellular architecture and dynamic molecular interplay in the nervous system have long challenged mechanistic studies of neurological diseases. Conventional approaches often miss the transient, low-affinity, or spatially confin...
Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine [0.03%]
基于转 translations cofactor(TCO)修饰抗体和氟
Sara Lopes van den Broek,Jonas Eriksson,Qiaojun Yang et al.
Sara Lopes van den Broek et al.
Background: Antibody-based positron emission tomography (PET) imaging holds great promise for visualizing disease-related proteins in the brain. However, its clinical utility is limited by poor antibody penetration across...
Microfluidic platform for understanding Parkinson's disease and α-synuclein conformation [0.03%]
用于理解帕金森病和α-突触核蛋白构象的微流控平台
Tregub Pavel,Zembatov Georgy,Namiot Eugenia et al.
Tregub Pavel et al.
Microfluidic systems are an innovative engineering solution that is increasingly being used in a wide range of scientific fields. These systems use fluids in microchannels (1 to 300 microns) to analyze extremely small volumes of sample and ...