Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies [0.03%]
阿尔茨海默病和帕金森病中的神经炎症：发病机制与治疗策略
Qin-Qin Wang,Qing-Qing Sun,Yong-Shun Guo et al.
Qin-Qin Wang et al.
Neuroinflammation is increasingly recognized as a key contributor and amplifier associated with the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD). Neuroinflammation occurs throughout various stages of these diseases ...
Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease [0.03%]
人类大脑基因表达谱在阿尔茨海默病和帕金森病中的应用
Yi Xiao,Shichan Wang,Yanbing Hou et al.
Yi Xiao et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common age-related neurodegenerative disorders. Allen Human Brain Atlas (AHBA) provides high-resolution transcriptomic data across 102 brain regions with multi-site samp...
Functional analysis of late-onset Alzheimer's disease risk genes in Caenorhabditis elegans identifies regulators of neuronal aging [0.03%]
秀丽隐杆线虫功能分析鉴定出调节神经元衰老的阿尔茨海默病晚发风险基因
Swapnil G Waghmare,Meera M Krishna,Emily C Maccoux et al.
Swapnil G Waghmare et al.
Protein kinase CK2α' as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy [0.03%]
蛋白激酶CK2α'作为调控tau病中神经免疫信号和突触功能障碍的双重调节因子
Angel White,Peter Gavrilyuk,Persephone Gu et al.
Angel White et al.
Background: Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein kinase CK2 is a holoenzyme...
Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism [0.03%]
植物来源的线粒体通过重新编程小胶质细胞的线粒体能量代谢来缓解与衰老相关的神经退行性病变
Yun Teng,Chao Luo,Qingbo Xu et al.
Yun Teng et al.
Background: Intercellular mitochondrial transfer is pivotal in both healthy and pathological states. Supplementing healthy mitochondria is emerging as a promising therapeutic approach for various diseases. Non-immunogenic...
Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD [0.03%]
溶酶体自噬可保护ANXA11淀粉样纤维毒性并抑制其在FTLD中的传播
Honglin Zheng,Haiyang Luo,Yongting Lu et al.
Honglin Zheng et al.
Background: Accumulation of Annexin A11 (ANXA11) aggregates is a distinct pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While genetic studies have linked ANXA11...
Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy [0.03%]
衰老大脑中的代谢交叉对话：将星形胶质细胞-神经元偶联作为稳态恢复和治疗靶点
Lihui Qian,Yanting Deng,Meiying Song et al.
Lihui Qian et al.
Astrocytes, the most abundant glial cells in the central nervous system, play increasingly recognized roles in metabolic regulation beyond their classical supportive functions. This review summarizes current understanding of astrocyte morph...
Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease [0.03%]
靶向溶酶体pH可恢复GBA1突变帕金森病中的线粒体质量控制
Preethi Sheshadri,Maria Alicia Costa-Besada,Alessia Fisher et al.
Preethi Sheshadri et al.
Background: Heterozygous mutations in the glucocerebrosidase gene (GBA1), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson's disease (PD). The pathophysiological co...
Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration [0.03%]
持久的PirB切割驱动高尔基体定向转运缺陷，导致神经退行性病变
Wu-Bo Han,Xian-Dong Liu,Chang-Fei Tang et al.
Wu-Bo Han et al.
Background: Extensive research evidence indicates that neuronal immune receptors play a critical role in Alzheimer's disease (AD). However, it remains unclear how these receptors convert extracellular signals into cellula...
From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease [0.03%]
从表型到生物学：帕金森病生物液、组织、影像和数字生物标志物的多模态路线图
Zhenwei Yu,Dongning Su,Siming Li et al.
Zhenwei Yu et al.
The definition of Parkinson's disease (PD) is undergoing a profound transformation from a "clinical syndrome" to a "biological entity", with development of two objective biological classification systems, the NSD-ISS (Neuronal Alpha-Synucle...