Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications [0.03%]
衰老和神经退行性疾病中的免疫衰老：证据、关键特征及治疗意义
Zhichun Chen,Zixu Mao,Weiting Tang et al.
Zhichun Chen et al.
Aging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders. Immun...
Francesca Lozzi,Emanuela Camera,Giorgia Cardinali et al.
Francesca Lozzi et al.
Neurodegenerative diseases (NDDs), including Parkinson's disease and Alzheimer's disease, are major age-related disorders characterized by progressive neuronal degeneration and a decline in cognitive and motor functions. Managing NDDs poses...
Neurotrophic factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice [0.03%]
神经营养因子-α1/羧肽酶E通过调节关键蛋白网络来挽救阿尔茨海默病小鼠的神经变性、缺陷型突触生成和受损自噬作用
Lan Xiao,Pranav Sharma,Xuyu Yang et al.
Lan Xiao et al.
Background: The global aging population is increasingly inflicted with Alzheimer's disease (AD), but a cure is still unavailable. Neurotrophic factor-α1/carboxypeptidase E (NF-α1/CPE) gene therapy has been shown to prev...
Attenuating α-synuclein pathology in mice with in situ engineered astrocytes [0.03%]
通过原位工程胶质细胞减弱小鼠中的α-突触核蛋白病理学现象
Xiao-Yu Du,Jing Zhou,Jie Zhu et al.
Xiao-Yu Du et al.
Background: α-Synuclein oligomers (α-synOs) contribute to the initiation and progression of Parkinson's disease (PD) by promoting neuronal death and activating glial cells. Clearing α-synOs while maintaining tissue hom...
Transplantation of hiPSC-derived pericytes rescues Alzheimer's disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles [0.03%]
人诱导多能干细胞衍生的周细胞移植通过富含IGF2的凋亡小体拯救APOE4/4小鼠的阿尔茨海默病表型
Chuanfeng Xiong,Yao Tang,Junhua Chen et al.
Chuanfeng Xiong et al.
Background: Effective therapies for Alzheimer's disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood-brain barrier (BBB) disruption are thought...
Harnessing cervical lymphatic mechanics to enhance amyloid clearance: a paradigm shift in Alzheimer's therapeutics? [0.03%]
利用颈部淋巴管力学增强淀粉样蛋白清除：阿尔茨海默病治疗的范式转变？
Wei Wang,Junhui Lv,Zihao Xu et al.
Wei Wang et al.
Xiaoshan Qi,Kedong Zhu,Wei Ke et al.
Xiaoshan Qi et al.
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been demonstrated to increase the risk of late-onset Alzheimer's disease (AD) and Nasu-Hakola disease. As a type I transmembrane receptor, TREM2 is predomina...
Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases [0.03%]
一组运动神经元疾病中极罕见的遗传变异的共同负担
Gang Wu,Wenan Chen,Joanne Wuu et al.
Gang Wu et al.
SIK2-mediated phosphorylation of GABARAPL2 facilitates autophagosome-lysosome fusion and rescues neurodegeneration in an Alzheimer's disease model [0.03%]
SIK2介导的GABARAPL2磷酸化促进自噬体-溶酶体融合并缓解阿尔茨海默病模型小鼠的神经退行性病变
Xiaoman Dai,Ziling Ye,Chen Wang et al.
Xiaoman Dai et al.
Background: Defective autophagic flux is implicated in Alzheimer's disease (AD), but the molecular mechanisms underlying this process are not fully understood. Salt-inducible kinase 2 (SIK2) is associated with autophagic ...
Disease-disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes [0.03%]
疾病间的相互作用：神经退行性疾病与癌症、病毒感染和二型糖尿病的分子联系
Yuxi Lin,Je Min Yoo,Yan Li et al.
Yuxi Lin et al.
Neurodegenerative disorders, notably Alzheimer's and Parkinson's diseases, are unified by progressive neuronal loss and aberrant protein aggregation. Growing evidence indicates that these conditions are linked to cancer, infectious diseases...