Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration [0.03%]
持久的PirB切割驱动高尔基体定向转运缺陷，导致神经退行性病变
Wu-Bo Han,Xian-Dong Liu,Chang-Fei Tang et al.
Wu-Bo Han et al.
Background: Extensive research evidence indicates that neuronal immune receptors play a critical role in Alzheimer's disease (AD). However, it remains unclear how these receptors convert extracellular signals into cellula...
From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease [0.03%]
从表型到生物学：帕金森病生物液、组织、影像和数字生物标志物的多模态路线图
Zhenwei Yu,Dongning Su,Siming Li et al.
Zhenwei Yu et al.
The definition of Parkinson's disease (PD) is undergoing a profound transformation from a "clinical syndrome" to a "biological entity", with development of two objective biological classification systems, the NSD-ISS (Neuronal Alpha-Synucle...
Ketogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges [0.03%]
生酮饮食作为神经退行性疾病治疗策略：从机制到转化挑战
Ana Margarida Salgueiro,Marisa Ferreira-Marques,Rodrigo F N Ribeiro et al.
Ana Margarida Salgueiro et al.
The ketogenic diet (KD) is increasingly recognized as a promising therapeutic strategy for neurodegenerative disorders because of its multifaceted impacts on key pathophysiological mechanisms. This review explores the molecular pathways thr...
Mesenchymal stromal cells and neuroinflammation: a multimodal approach to neuroprotection and future therapeutic horizons [0.03%]
间充质基质细胞与神经炎症：多模式的神经保护及未来治疗前景
Alexandro Angelo Bufi,Andrea Papait,Peter Ponsaerts et al.
Alexandro Angelo Bufi et al.
As the global population ages, neurodegenerative and neuroinflammatory diseases are becoming a rapidly growing public health challenge, with available interventions remaining largely symptomatic and often only modestly affecting long-term d...
Calbindin-D28k deficiency mediates tau-driven hippocampal hyperexcitement and cognitive impairment [0.03%]
钙结合蛋白D28k缺乏介导tau引起的海马高频兴奋及认知障碍
Yang Gao,Xiaoqing Tao,Yuying Wang et al.
Yang Gao et al.
Background: Medial temporal lobe hyperexcitation or seizures originating from the hippocampus are frequently observed in Alzheimer's disease (AD) patients, contributing to accelerated cognitive decline. As the hippocampus...
The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson's disease [0.03%]
自噬溶酶体途径在帕金森病病理发生中的作用及治疗靶点研究进展
Takahiro Shimizu,Sanem Isik,Nitika Kamath et al.
Takahiro Shimizu et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and the accumulation of misfolded α-synuclein, yet the underlying mechanisms remain incompletely understood. Over the past two d...
A new dawn for Parkinson's disease: commentary on the emergence of stem cell-based therapies [0.03%]
帕金森病的新生涯-基于干细胞疗法的出现评论文章
Rosalie Elvira,Wai Hon Chooi,Hongyan Wang et al.
Rosalie Elvira et al.
The field of regenerative medicine for Parkinson's disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement therapy using stem cell-derived do...
N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease [0.03%]
阿尔茨海默病新的病理截短tau蛋白种类N端乙酰化Met11-Tau及其功能意义
Sarah Guedjdal,Coline Leghay,Maxime Derisbourg et al.
Sarah Guedjdal et al.
Background: Tauopathies are a group of neurodegenerative diseases, including Alzheimer's disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, truncated varia...
The Drp1-CoQ10-Coa6-ETC axis represents a therapeutic potential for working memory impairment caused by neuronal mitochondrial dysfunction [0.03%]
Drp1-CoQ10-Coa6-线粒体电子传递链轴代表了改善由神经元线粒体功能障碍引起的工作记忆损伤的潜在治疗靶点
Jingjing Tie,Shujiao Li,Xin Huang et al.
Jingjing Tie et al.
Background: Coenzyme Q10 (CoQ10) is a key mitochondrial electron carrier and a widely used dietary supplement with potential neurological benefits. However, the mechanisms underlying its effect in ameliorating memory defi...
Dysfunction of the neurovascular unit as a temporal driver in Alzheimer's pathogenesis [0.03%]
神经血管单元功能障碍在阿尔茨海默病发病机制中的时间驱动作用
Lifang Wang,Lei Han,Shiping Liu
Lifang Wang
Extensive studies have shown that cerebrovascular dysfunction is a critical factor in the onset and progression of Alzheimer's disease (AD). Neurovascular unit (NVU) is impaired in AD brains, including damage of tight junction between endot...