The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities [0.03%]
海马的空间记忆环路：从健康功能到阿尔茨海默病的早期病变及转化机遇
Yujie Song,Junjun Ni,Hong Qing et al.
Yujie Song et al.
Hippocampus (HPC)-associated spatial memory deficits are one of the earliest symptoms of Alzheimer's disease (AD). Current pharmacological treatments only alleviate the symptoms but do not prevent disease progression. The emergence of neuro...
Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer's disease: associations with Aβ, tau, synaptic proteins and APOE ε4 [0.03%]
阿尔茨海默病中神经元外泌体和脑中的突触素2A减少与淀粉样蛋白、tau及APOEε4相关性研究
Jana Nussbaumer,Aatmika Barve,Valentin Zufferey et al.
Jana Nussbaumer et al.
Background: Alzheimer's disease (AD) is characterized by accumulation of amyloid-β (Aβ) plaques, tau neurofibrillary Tangles and synaptic dysfunction. The aim of this study was to map the distributions of synaptic vesic...
Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease [0.03%]
针对glymphatic系统：阿尔茨海默病不同阶段的Aβ积累与光疗策略
Danrui Zhao,Junting Wang,Yirui Zhu et al.
Danrui Zhao et al.
The glymphatic system serves as the brain's clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer's disease (AD). Modulating cerebrospinal fluid (CSF)-based clearance and targe...
Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases [0.03%]
神经炎症中的糖基化：机制、影响及神经退行性疾病的治疗策略
Shenglan Cheng,Bo Xiao,Zhaohui Luo
Shenglan Cheng
Neuroinflammation is a key pathological mechanism underlying neurodegenerative diseases, and intricately interacts with protein glycosylation. Emerging evidence suggests that aberrant glycosylation disrupts immune homeostasis, activates mic...
Disarming COX-1 to disrupt Alzheimer's inflammatory trajectory: preclinical insights and translational promise [0.03%]
使COX-1失活以中断阿尔茨海默病的炎症发展轨迹：前期洞察与转化前景
Gilda Loffredo,Marcello D&#x;Amelio
Gilda Loffredo
Wensheng Li,Yuran Gui,Cuiping Guo et al.
Wensheng Li et al.
Mitochondria produce adenosine triphosphate (ATP), the main source of cellular energy. To maintain normal function, cells rely on a complex mitochondrial quality control (MQC) system that regulates mitochondrial homeostasis, including mitoc...
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington's disease models [0.03%]
在亨廷顿病模型中恢复海马GABA能神经元的CB1受体功能可缓解记忆缺损
Nadia Di Franco,Iker Bengoetxea de Tena,Andrea Sanchez-Ruiz et al.
Nadia Di Franco et al.
Background: Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are well-established hallmarks of Huntington's disease (HD). As a result, significant research effor...
Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment [0.03%]
小鼠中环氧合酶-1的缺失可保护小胶质细胞免受神经炎症侵害并减轻认知障碍病症
Jie Wang,Hong Ni,Yu Wang et al.
Jie Wang et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive ...
Michael Okafor,Peter Faller,Nicolas Vitale
Michael Okafor
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive decline of cognitive functions, yet its underlying aetiology remains elusive. While amyloid-β (Aβ) and tau pathologies have been extensively stu...
Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease [0.03%]
针对阿尔茨海默病的BACE1 siRNA靶向递送联合治疗研究
Zhaohan Li,Jun Yang,Jianan Li et al.
Zhaohan Li et al.
Background: The deposition of toxic aggregated amyloid-β (Aβ), resulting from continuous cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase, is a key pathogenic event i...