Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington's disease [0.03%]
胆固醇鼻至脑输送可能是亨廷顿舞蹈病的一种潜在治疗策略
Monica Favagrossa,Alice Passoni,Marta Valenza et al.
Monica Favagrossa et al.
Background: Huntington's disease (HD) is a genetically dominant neurodegenerative disorder characterized by several pathological mechanisms, including the disruption of brain cholesterol homeostasis. In several HD animal ...
Brain insulin resistance as a driver of proteinopathy in neurodegeneration: from cell-type-specific mechanisms to targeted therapeutics [0.03%]
脑胰岛素抵抗在神经退行性变中的作用：从细胞类型特异性机制到靶向治疗
Man Xiang,Si-Yu Cao,Xue-Heng Sun et al.
Man Xiang et al.
Neurodegenerative diseases are increasingly linked to systemic metabolic dysfunction, with brain insulin resistance (BIR) positioned as a central mediator. Yet translating this insight into effective therapies has proven remarkably difficul...
Transaldolase 1 contributes to pentose phosphate pathway disruption and synaptic dysfunction in Alzheimer's disease [0.03%]
醛缩酶1通过破坏磷酸戊糖途径和突触功能在阿尔茨海默病中的作用
Xiaoyu Hu,Ying Yu,Haorui Luo et al.
Xiaoyu Hu et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and synaptic dysfunction. Increasing evidence suggests that impaired glucose utilization is a major contr...
Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies [0.03%]
阿尔茨海默病和帕金森病中的神经炎症：发病机制与治疗策略
Qin-Qin Wang,Qing-Qing Sun,Yong-Shun Guo et al.
Qin-Qin Wang et al.
Neuroinflammation is increasingly recognized as a key contributor and amplifier associated with the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD). Neuroinflammation occurs throughout various stages of these diseases ...
Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease [0.03%]
人类大脑基因表达谱在阿尔茨海默病和帕金森病中的应用
Yi Xiao,Shichan Wang,Yanbing Hou et al.
Yi Xiao et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common age-related neurodegenerative disorders. Allen Human Brain Atlas (AHBA) provides high-resolution transcriptomic data across 102 brain regions with multi-site samp...
Functional analysis of late-onset Alzheimer's disease risk genes in Caenorhabditis elegans identifies regulators of neuronal aging [0.03%]
秀丽隐杆线虫功能分析鉴定出调节神经元衰老的阿尔茨海默病晚发风险基因
Swapnil G Waghmare,Meera M Krishna,Emily C Maccoux et al.
Swapnil G Waghmare et al.
Protein kinase CK2α' as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy [0.03%]
蛋白激酶CK2α'作为调控tau病中神经免疫信号和突触功能障碍的双重调节因子
Angel White,Peter Gavrilyuk,Persephone Gu et al.
Angel White et al.
Background: Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein kinase CK2 is a holoenzyme...
Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism [0.03%]
植物来源的线粒体通过重新编程小胶质细胞的线粒体能量代谢来缓解与衰老相关的神经退行性病变
Yun Teng,Chao Luo,Qingbo Xu et al.
Yun Teng et al.
Background: Intercellular mitochondrial transfer is pivotal in both healthy and pathological states. Supplementing healthy mitochondria is emerging as a promising therapeutic approach for various diseases. Non-immunogenic...
Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD [0.03%]
溶酶体自噬可保护ANXA11淀粉样纤维毒性并抑制其在FTLD中的传播
Honglin Zheng,Haiyang Luo,Yongting Lu et al.
Honglin Zheng et al.
Background: Accumulation of Annexin A11 (ANXA11) aggregates is a distinct pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While genetic studies have linked ANXA11...
Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy [0.03%]
衰老大脑中的代谢交叉对话：将星形胶质细胞-神经元偶联作为稳态恢复和治疗靶点
Lihui Qian,Yanting Deng,Meiying Song et al.
Lihui Qian et al.
Astrocytes, the most abundant glial cells in the central nervous system, play increasingly recognized roles in metabolic regulation beyond their classical supportive functions. This review summarizes current understanding of astrocyte morph...