Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer's disease [0.03%]
长期锻炼可增强阿尔茨海默病小鼠模型的脑膜淋巴管顺应性和引流能力
Yan Chen,Jiachen Cai,Yuzhu She et al.
Yan Chen et al.
Background: Meningeal lymphatic drainage is crucial for the clearance of amyloid β (Aβ), supporting the maintenance of brain homeostasis. This makes it a promising therapeutic target for Alzheimer's disease (AD). Long-t...
Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease [0.03%]
精神活性物质：阿尔茨海默病的新分子见解和治疗潜力
Chonglei Fu,Xuehui Li,Xiaoxing Liu et al.
Chonglei Fu et al.
Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promo...
Glutathione oxidation in cerebrospinal fluid as a biomarker of oxidative stress in amyotrophic lateral sclerosis [0.03%]
谷胱甘肽氧化作为氧化应激在肌萎缩侧索硬化中的生物标志物
Trong Khoa Pham,Nick Verber,Martin R Turner et al.
Trong Khoa Pham et al.
Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson's disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study [0.03%]
基于7T磁共振成像的帕金森病、原发性快速眼动睡眠行为异常及各种伴发综合征多巴胺能神经元高信号及铁沉积模式的一项诊断性研究
Dongning Su,Zhijin Zhang,Zhe Zhang et al.
Dongning Su et al.
Background: Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson's disease (PD) and can be effectively v...
Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson's disease model [0.03%]
帕金森病模型中AMPK-SENP1-Sirt3信号传导缺陷损害线粒体复合物I功能
Xiaoyu Sun,Jianyi Shen,Yimei Shu et al.
Xiaoyu Sun et al.
Background: Epidemiological studies have revealed increased Parkinson's disease (PD) risk among individuals exposed to pesticides like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP is frequently used to induce...
Immunization targeting diseased proteins in synucleinopathy and tauopathy: insights from clinical trials [0.03%]
Tau和α-突触核蛋白病的疾病相关蛋白免疫疗法：临床试验启示
Xiaoni Zhan,Gehua Wen,Xu Wu et al.
Xiaoni Zhan et al.
Synucleinopathies and tauopathies are neurodegenerative disorders characterized by the pathological accumulation of α-synuclein (α-syn) and tau proteins, respectively. These disorders are traditionally managed with symptomatic treatments ...
Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies [0.03%]
异常的α-突触核蛋白与突触素13结合，阻碍突触核蛋白病中细胞外囊泡的释放
Yasuo Miki,Shuji Shimoyama,Makoto T Tanaka et al.
Yasuo Miki et al.
Background: Despite increasing in vitro research, direct evidence of how abnormal α-synuclein (α-Syn) dysregulates vesicular transport and synaptic function in the human brain is lacking. ...
Pathological α-synuclein elicits granulovacuolar degeneration independent of tau [0.03%]
病理性的α-突触核蛋白独立于tau蛋白引发细胞内包涵体的聚集形成
Dylan J Dues,Madalynn L Erb,Alysa Kasen et al.
Dylan J Dues et al.
Background: Pathologic heterogeneity is a hallmark of Lewy body dementia (LBD), yet the impact of Lewy pathology on co-pathologies is poorly understood. Lewy pathology, containing α-synuclein, is often associated with re...
Diagnostic value of the motor band sign in amyotrophic lateral sclerosis: a 7T magnetic resonance imaging study [0.03%]
ALS Motor Band征的诊断价值：7T磁共振成像研究
Xunyan Huang,Zhe Zhang,Lin Chen et al.
Xunyan Huang et al.
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis [0.03%]
YAP1年龄依赖性降低通过上调Nr4a1-AKT/GSK-3β信号通路促进阿尔茨海默病病理进展
Ling Lei,Yilei Cheng,Anqi Yin et al.
Ling Lei et al.
Background: Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts for > 95% of all Alzheimer's disease (AD) cases. Yes-associated protein 1 (YAP1), an aging-dependent protein, is a ke...