Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells [0.03%]
脑内颗粒蛋白前体缺乏：神经元与非神经元细胞间的相互作用
Katarzyna Gaweda-Walerych,Vanessa Aragona,Simona Lodato et al.
Katarzyna Gaweda-Walerych et al.
Heterozygous mutations in GRN gene lead to insufficient levels of the progranulin (PGRN) protein, resulting in frontotemporal dementia (FTD) with TAR DNA-binding protein 43 (TDP-43) inclusions, classified pathologically as frontotemporal lo...
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients [0.03%]
基因治疗在渐冻人症上的突破：给百分之二十的ALS患者带来希望
Qingjian Xie,Kezheng Li,Yinuo Chen et al.
Qingjian Xie et al.
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that remains incurable. Although the etiologies of ALS are diverse and the precise pathogenic mechanisms are not fully understood, approximately 20% of ALS cases are caused...
Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans [0.03%]
光遗传学诱导TDP-43聚集损害秀丽隐杆线虫的神经元结构和行为
Kyung Hwan Park,Euihyeon Yu,Sooji Choi et al.
Kyung Hwan Park et al.
Background: Cytoplasmic aggregation of TAR DNA binding protein 43 (TDP-43) in neurons is one of the hallmarks of TDP-43 proteinopathy. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are c...
Nootropic foods in neurodegenerative diseases: mechanisms, challenges, and future [0.03%]
营养食品在神经退行性疾病中的作用：机制、挑战与未来方向
Le Anh Minh Nguyen,Courtney Wayne Simons,Raymond Thomas
Le Anh Minh Nguyen
Neurodegenerative diseases (NDDs) such as Alzheimer's and Parkinson's disease are increasing globally and represent a significant cause of age-related death in the population. Recent studies emphasize the strong association between environm...
Blood-brain barrier disruption: a pervasive driver and mechanistic link between traumatic brain injury and Alzheimer's disease [0.03%]
血脑屏障破坏：创伤性脑损伤和阿尔茨海默病之间的机制联系及普遍驱动因素
Bryan Sun,Lulin Li,Odette A Harris et al.
Bryan Sun et al.
Traumatic brain injury (TBI) has emerged as a significant risk factor for Alzheimer's disease (AD), a complex and devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Both conditions share a...
Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer's disease: a comprehensive review of the characteristics and therapeutic strategies [0.03%]
阿尔茨海默病中淀粉样蛋白β和tau聚集及解离的双重调节：特点和治疗策略的综合性综述
Yunkwon Nam,Soo Jung Shin,Vijay Kumar et al.
Yunkwon Nam et al.
Alzheimer's disease (AD) is not a single-cause disease; rather, it is a complex neurodegenerative disease involving multiple pathological pathways influenced by various risk factors. Aggregation and accumulation of amyloid beta (Aβ) and ta...
Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging [0.03%]
反转座子：从神经发育和衰老的角度对神经性疾病的新认识
Wenchuan Zhang,Chenxuan Huang,Haiyang Yao et al.
Wenchuan Zhang et al.
Neurological disorders present considerable challenges in diagnosis and treatment due to their complex and diverse etiology. Retrotransposons are a type of mobile genetic element that are increasingly revealed to play a role in these diseas...
Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity [0.03%]
细胞外PHF-tau调节星形胶质细胞线粒体动态并介导神经元连接
Valentin Zufferey,Aatmika Barve,Enea Parietti et al.
Valentin Zufferey et al.
Background: Tau is an intracellular protein that plays a crucial role in stabilizing microtubules. However, it can aggregate into various forms under pathological conditions and be secreted into the brain parenchyma. Whil...
Improving vulnerable Calbindin1- neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory [0.03%]
改善海马腹侧区易受伤害的Calbindin1-神经元可挽救由tau引起的陈述性记忆损伤
Huiyang Lei,Jingru Lv,Fuqiang Zhang et al.
Huiyang Lei et al.
Background: Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable b...
Chronic subthalamic nucleus deep brain stimulation reduces pathological TrkB aggregates in a Parkinson's disease rat model [0.03%]
慢性苍白球深部脑刺激减少帕金森病大鼠模型中的病理TrkB聚合体
Tobias Petschner,Katarina Hofman,Jia Zhi Chen et al.
Tobias Petschner et al.