Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease [0.03%]
针对glymphatic系统：阿尔茨海默病不同阶段的Aβ积累与光疗策略
Danrui Zhao,Junting Wang,Yirui Zhu et al.
Danrui Zhao et al.
The glymphatic system serves as the brain's clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer's disease (AD). Modulating cerebrospinal fluid (CSF)-based clearance and targe...
Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases [0.03%]
神经炎症中的糖基化：机制、影响及神经退行性疾病的治疗策略
Shenglan Cheng,Bo Xiao,Zhaohui Luo
Shenglan Cheng
Neuroinflammation is a key pathological mechanism underlying neurodegenerative diseases, and intricately interacts with protein glycosylation. Emerging evidence suggests that aberrant glycosylation disrupts immune homeostasis, activates mic...
Disarming COX-1 to disrupt Alzheimer's inflammatory trajectory: preclinical insights and translational promise [0.03%]
使COX-1失活以中断阿尔茨海默病的炎症发展轨迹：前期洞察与转化前景
Gilda Loffredo,Marcello D&#x;Amelio
Gilda Loffredo
Wensheng Li,Yuran Gui,Cuiping Guo et al.
Wensheng Li et al.
Mitochondria produce adenosine triphosphate (ATP), the main source of cellular energy. To maintain normal function, cells rely on a complex mitochondrial quality control (MQC) system that regulates mitochondrial homeostasis, including mitoc...
Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington's disease models [0.03%]
在亨廷顿病模型中恢复海马GABA能神经元的CB1受体功能可缓解记忆缺损
Nadia Di Franco,Iker Bengoetxea de Tena,Andrea Sanchez-Ruiz et al.
Nadia Di Franco et al.
Background: Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are well-established hallmarks of Huntington's disease (HD). As a result, significant research effor...
Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment [0.03%]
小鼠中环氧合酶-1的缺失可保护小胶质细胞免受神经炎症侵害并减轻认知障碍病症
Jie Wang,Hong Ni,Yu Wang et al.
Jie Wang et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive ...
Michael Okafor,Peter Faller,Nicolas Vitale
Michael Okafor
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive decline of cognitive functions, yet its underlying aetiology remains elusive. While amyloid-β (Aβ) and tau pathologies have been extensively stu...
Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease [0.03%]
针对阿尔茨海默病的BACE1 siRNA靶向递送联合治疗研究
Zhaohan Li,Jun Yang,Jianan Li et al.
Zhaohan Li et al.
Background: The deposition of toxic aggregated amyloid-β (Aβ), resulting from continuous cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase, is a key pathogenic event i...
Role of extracellular vesicle-carried ncRNAs in the interactive 'dialogue' within the brain and beyond: emerging theranostic epigenetic modifiers in brain-derived nanoplatforms [0.03%]
外泌体递送ncRNA在脑内外交互对话中的作用：基于脑源性纳米平台的治疗诊断表观遗传修饰剂的新出现_role of extracellular vesicle-carried ncrnas in the interactive dialogue within the brain and beyond: emerging theranostic epigenetic modifiers in brain-derived nanoplatforms
Nima Sanadgol,Pegah Mousavi,Fatemeh Sadri et al.
Nima Sanadgol et al.
Proper brain function and overall health critically rely on the bidirectional communications among cells in the central nervous system and between the brain and other organs. These interactions are widely acknowledged to be facilitated by v...
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer's disease [0.03%]
轴突tau减少可改善阿尔茨海默病小鼠模型中的tau和淀粉样蛋白病理变化
Abdolhossein Zare,Saeede Salehi,Jakob M Bader et al.
Abdolhossein Zare et al.
Background: Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer's disease (AD). Tau pathology occurs in axons of affected neurons and tau removal from axons migh...