Attenuating α-synuclein pathology in mice with in situ engineered astrocytes [0.03%]
通过原位工程胶质细胞减弱小鼠中的α-突触核蛋白病理学现象
Xiao-Yu Du,Jing Zhou,Jie Zhu et al.
Xiao-Yu Du et al.
Background: α-Synuclein oligomers (α-synOs) contribute to the initiation and progression of Parkinson's disease (PD) by promoting neuronal death and activating glial cells. Clearing α-synOs while maintaining tissue hom...
Transplantation of hiPSC-derived pericytes rescues Alzheimer's disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles [0.03%]
人诱导多能干细胞衍生的周细胞移植通过富含IGF2的凋亡小体拯救APOE4/4小鼠的阿尔茨海默病表型
Chuanfeng Xiong,Yao Tang,Junhua Chen et al.
Chuanfeng Xiong et al.
Background: Effective therapies for Alzheimer's disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood-brain barrier (BBB) disruption are thought...
Harnessing cervical lymphatic mechanics to enhance amyloid clearance: a paradigm shift in Alzheimer's therapeutics? [0.03%]
利用颈部淋巴管力学增强淀粉样蛋白清除：阿尔茨海默病治疗的范式转变？
Wei Wang,Junhui Lv,Zihao Xu et al.
Wei Wang et al.
Xiaoshan Qi,Kedong Zhu,Wei Ke et al.
Xiaoshan Qi et al.
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been demonstrated to increase the risk of late-onset Alzheimer's disease (AD) and Nasu-Hakola disease. As a type I transmembrane receptor, TREM2 is predomina...
Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases [0.03%]
一组运动神经元疾病中极罕见的遗传变异的共同负担
Gang Wu,Wenan Chen,Joanne Wuu et al.
Gang Wu et al.
SIK2-mediated phosphorylation of GABARAPL2 facilitates autophagosome-lysosome fusion and rescues neurodegeneration in an Alzheimer's disease model [0.03%]
SIK2介导的GABARAPL2磷酸化促进自噬体-溶酶体融合并缓解阿尔茨海默病模型小鼠的神经退行性病变
Xiaoman Dai,Ziling Ye,Chen Wang et al.
Xiaoman Dai et al.
Background: Defective autophagic flux is implicated in Alzheimer's disease (AD), but the molecular mechanisms underlying this process are not fully understood. Salt-inducible kinase 2 (SIK2) is associated with autophagic ...
Disease-disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes [0.03%]
疾病间的相互作用：神经退行性疾病与癌症、病毒感染和二型糖尿病的分子联系
Yuxi Lin,Je Min Yoo,Yan Li et al.
Yuxi Lin et al.
Neurodegenerative disorders, notably Alzheimer's and Parkinson's diseases, are unified by progressive neuronal loss and aberrant protein aggregation. Growing evidence indicates that these conditions are linked to cancer, infectious diseases...
Beyond amyloid: nanobody-mediated neuroinflammatory therapy for Alzheimer's disease [0.03%]
超越淀粉样蛋白：阿尔茨海默病的纳米抗体介导的神经炎症疗法
Soukaina Amniouel,Jessica Suh,Wei Zheng et al.
Soukaina Amniouel et al.
Alzheimer's disease (AD) is one of the most common and devastating neurodegenerative diseases, characterized by accumulation of amyloid-beta (Aβ) plaques, neurofibrillary tangles of tau protein, and persistence of neuroinflammation, leadin...
The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities [0.03%]
海马的空间记忆环路：从健康功能到阿尔茨海默病的早期病变及转化机遇
Yujie Song,Junjun Ni,Hong Qing et al.
Yujie Song et al.
Hippocampus (HPC)-associated spatial memory deficits are one of the earliest symptoms of Alzheimer's disease (AD). Current pharmacological treatments only alleviate the symptoms but do not prevent disease progression. The emergence of neuro...
Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer's disease: associations with Aβ, tau, synaptic proteins and APOE ε4 [0.03%]
阿尔茨海默病中神经元外泌体和脑中的突触素2A减少与淀粉样蛋白、tau及APOEε4相关性研究
Jana Nussbaumer,Aatmika Barve,Valentin Zufferey et al.
Jana Nussbaumer et al.
Background: Alzheimer's disease (AD) is characterized by accumulation of amyloid-β (Aβ) plaques, tau neurofibrillary Tangles and synaptic dysfunction. The aim of this study was to map the distributions of synaptic vesic...