Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis [0.03%]
σ-1受体的正向调节：一种延缓肌萎缩侧索硬化症病情进展的新策略
Julien Le Friec,Hugo Mourier,Simon Couly et al.
Julien Le Friec et al.
Background: Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of motor neurons, leading to muscle weakness and progressive paralysis. Currently, no treatment is available to halt or reverse the progress...
Lipofuscin accumulation in aging and neurodegeneration: a potential "timebomb" overlooked in Alzheimer's disease [0.03%]
脂褐质在衰老和神经退行性疾病中的积累：阿尔茨海默病中被忽视的“定时炸弹”？
Godfried Dougnon,Hideaki Matsui
Godfried Dougnon
Lipofuscin, a marker of aging, is the accumulation of autofluorescent granules within microglia and postmitotic cells such as neurons. Lipofuscin has traditionally been regarded as an inert byproduct of cellular degradation. However, recent...
Microglia in the crosstalk between peripheral and central nervous systems in Parkinson's disease [0.03%]
帕金森病中微胶质细胞在周围神经系统和中枢神经系统的相互作用中的作用
Tianbai Li,Tao Qiu,Fei Jiang et al.
Tianbai Li et al.
Parkinson's disease (PD) is increasingly recognized as a multisystem disorder involving pathological α-synuclein (α-syn) accumulation and widespread neuroimmune dysregulation. Microglia, the resident immune cells in the central nervous sy...
Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [0.03%]
脑膜淋巴系统作为神经退行性疾病治疗靶点的潜力
Yijia Feng,Shengya Wang,Huwei Xia et al.
Yijia Feng et al.
Advancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub f...
LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner [0.03%]
LRRK2 G2019S突变通过Drp1-STX17依赖性方式影响线粒体转移功能
Mei Ding,Fen Wang,Lan-Lan Jiang et al.
Mei Ding et al.
Background: Previous studies have shown that astrocytes can transfer healthy mitochondria to dopaminergic (DA) neurons, which may serve as an intrinsic neuroprotective mechanism in Parkinson's disease (PD). LRRK2 G2019S i...
Stratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles [0.03%]
阿尔茨海默病患者脑源性细胞外囊泡的分层表明其具有独特的蛋白质组含量和较小尺寸细胞外囊泡更高的致病种子能力
Marie Oosterlynck,Elodie Leroux,Balasubramaniam Namasivayam et al.
Marie Oosterlynck et al.
Background: Alzheimer's disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propag...
Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats [0.03%]
基于分子葡萄糖成像技术的小脑深部核刺激对帕金森病模型大鼠功能脑网络重塑的影响研究
Jiazhi Chen,Ningfei Li,Muthuraman Muthuraman et al.
Jiazhi Chen et al.
Background: In order to elucidate the neuromodulatory mechanisms underlying therapeutic subthalamic deep brain stimulation (DBS), we here reverse-translate a methodological pipeline that integrates neurostimulation effect...
Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications [0.03%]
衰老和神经退行性疾病中的免疫衰老：证据、关键特征及治疗意义
Zhichun Chen,Zixu Mao,Weiting Tang et al.
Zhichun Chen et al.
Aging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders. Immun...
Francesca Lozzi,Emanuela Camera,Giorgia Cardinali et al.
Francesca Lozzi et al.
Neurodegenerative diseases (NDDs), including Parkinson's disease and Alzheimer's disease, are major age-related disorders characterized by progressive neuronal degeneration and a decline in cognitive and motor functions. Managing NDDs poses...
Neurotrophic factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice [0.03%]
神经营养因子-α1/羧肽酶E通过调节关键蛋白网络来挽救阿尔茨海默病小鼠的神经变性、缺陷型突触生成和受损自噬作用
Lan Xiao,Pranav Sharma,Xuyu Yang et al.
Lan Xiao et al.
Background: The global aging population is increasingly inflicted with Alzheimer's disease (AD), but a cure is still unavailable. Neurotrophic factor-α1/carboxypeptidase E (NF-α1/CPE) gene therapy has been shown to prev...