NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer's disease [0.03%]
NDST3抑制恢复溶酶体酸化并改善阿尔茨海默病中的淀粉样蛋白-β和MAPT/tau病理学
Chuanhua Ge,Kun Wang,Huiyuan Tang et al.
Chuanhua Ge et al.
Background: Impairment of lysosomal acidification has recently been identified as a critical driver of amyloid-β and MAPT/tau pathology in Alzheimer's disease (AD). Restoring lysosomal acidification is a promising strate...
Drug repurposing for disease-modifying effects in multiple system atrophy [0.03%]
老药新用在多系统萎缩疾病修正治疗中的应用展望
Seong Ho Jeong,Jin Young Shin,Phil Hyu Lee
Seong Ho Jeong
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder lacking any proven disease-modifying therapy. Drug repurposing offers a strategy to accelerate the development of treatments by utilizing agents originally ap...
Tau conformation, distribution and PET imaging correlations in progressive supranuclear palsy [0.03%]
进行性核上性瘫痪中tau构象、分布及正电子发射断层扫描影像的相关性研究
Chong Dong,Jing-Hong Ma,Hong-Wen Qiao et al.
Chong Dong et al.
Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by aggregation of pathological tau. Recent advances in cryo-electron microscopy have enabled the classification of tauopathies at near-atomic resolution, revealing di...
Deciphering the microenvironment of adult neurogenesis: a perspective from neurodegenerative diseases [0.03%]
成人神经发生微环境的解析：来自神经退行性疾病的视角
Zheng-Kai Lao,Nan-Jie Xu
Zheng-Kai Lao
Neurodegenerative diseases are characterized by progressive neuron loss and brain atrophy. While conventional studies focused on neuronal death as the primary cause of these diseases, accumulating evidence suggests that impaired neurogenesi...
Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases [0.03%]
轴索病变：神经退行性疾病的机制及潜在治疗靶点
Ruinan Shen,Kijung Sung,Jianqing Ding et al.
Ruinan Shen et al.
Axons are unique structural and functional features of nerve cells, which play a critical role in regulating neuronal homeostasis. Dysfunction and degeneration of axons (axonopathy) has been established as an early and prominent contributin...
Molecular mechanisms of exercise-induced improvements in Alzheimer's disease: a focus on lipid homeostasis [0.03%]
运动改善阿尔茨海默病的分子机制：以脂质稳态为重点的研究
Jianfan Zhou,Xianliang Zhang,Shuting Yin et al.
Jianfan Zhou et al.
Alzheimer's disease (AD) is the most prevalent type of dementia, and its pathophysiological mechanisms involve multiple factors, including genomic factors, metabolomic factors, and environmental factors. Lipid dysregulation occurs both cent...
Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms [0.03%]
肠道启动的α-突触核蛋白原纤维驱动帕金森病表型：REM睡眠行为障碍和其他非运动症状的时间映射
Daniel Dautan,Wojciech Paslawski,Sergio G Montejo et al.
Daniel Dautan et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by both motor and non-motor symptoms. Although non-motor features such as gastrointestinal and sleep disturbances often precede motor...
Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementia [0.03%]
利用超声抑制TRPA1依赖性星形胶质细胞活化对路易小体痴呆模型提供神经保护作用
Ji Hun Kim,Keunhyung Lee,Minseok Koo et al.
Ji Hun Kim et al.
Background: The pathology of Lewy body dementia (LBD) features neuronal α-synuclein (α-syn) accumulation and astrocytic hyperactivation in cognitive brain circuits. Ultra-low-intensity ultrasound (ULIUS) modulates astro...
SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer's disease [0.03%]
人神经嵴来源鼻甲干细胞治疗阿尔茨海默病效果与SSEA3和CD105阳性的关联性研究
Jung Yeon Lim,Jung Eun Lee,Minho Lee et al.
Jung Yeon Lim et al.
Background: Stem cells have the potential to treat Alzheimer's disease (AD), but clinical outcomes are unpredictable due to inter-donor differences in stem cell properties. This study aimed to determine whether the plurip...
Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinson's disease mouse model by modulating gut microbiota dysbiosis and inhibiting the NLRP3 signaling pathway [0.03%]
Bacteroides coprocola通过调节肠道菌群失调和抑制NLRP3信号通路来保护罗滕酮诱导的帕金森病小鼠模型中的多巴胺能神经元
Zixian Liu,Jiabei Nie,Yimei Li et al.
Zixian Liu et al.
Background: Parkinson's disease (PD) is a prevalent neurodegenerative disease and its pathogenesis is still unclear. Emerging evidence supports the gut-origin hypothesis, highlighting gut microbiota dysbiosis as a contrib...