AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders [0.03%]
氨丙酸受体扩散捕获机制可作为神经退行性疾病和神经精神疾病的早期治疗靶点
Daniel Choquet,Patricio Opazo,Hongyu Zhang
Daniel Choquet
Over the past two decades, there has been a growing recognition of the physiological importance and pathological implications surrounding the surface diffusion of AMPA receptors (AMPARs) and their diffusional trapping at synapses. AMPAR sur...
Second-generation anti-amyloid monoclonal antibodies for Alzheimer's disease: current landscape and future perspectives [0.03%]
阿尔茨海默病第二代抗淀粉样蛋白单克隆抗体：现状与未来展望
Byeong-Hyeon Kim,Sujin Kim,Yunkwon Nam et al.
Byeong-Hyeon Kim et al.
Alzheimer's disease (AD) is the most common type of dementia. Monoclonal antibodies (MABs) serve as a promising therapeutic approach for AD by selectively targeting key pathogenic factors, such as amyloid-β (Aβ) peptide, tau protein, and ...
Correction: Inflammasomes in neurodegenerative diseases [0.03%]
关于炎症小体在神经退行性疾病中的作用的更正：炎症小体与神经退行性疾病的关系
Qianchen Wang,Songwei Yang,Xuan Zhang et al.
Qianchen Wang et al.
Published Erratum
Translational neurodegeneration. 2025 Jan 23;14(1):5. DOI:10.1186/s40035-025-00468-7 2025
Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington's disease [0.03%]
反义寡核苷酸药物在肌萎缩侧索硬化和亨廷顿病中的应用
Kaili Ou,Qingqing Jia,Dandan Li et al.
Kaili Ou et al.
Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches ha...
Bin Xu,Xia Lei,Ying Yang et al.
Bin Xu et al.
Proteinopathies in neurology typically refer to pathological changes in proteins associated with neurological diseases, such as the aggregation of amyloid β and Tau in Alzheimer's disease, α-synuclein in Parkinson's disease and multiple s...
Cerebrospinal fluid cyclase-associated protein 2 is increased in Alzheimer's disease and correlates with tau pathology [0.03%]
阿尔茨海默病患者脑脊液中的环核苷酸磷酸二酯酶相关蛋白2增加并与tau病理改变有关
Alessandro Padovani,Andrea Pilotto,Silvia Pelucchi et al.
Alessandro Padovani et al.
Correction: CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation [0.03%]
校正：CD2AP缺乏通过p38MAPK激活加重阿尔茨海默病表型和病理学
Yan-Yan Xue,Zhe-Sheng Zhang,Rong-Rong Lin et al.
Yan-Yan Xue et al.
Published Erratum
Translational neurodegeneration. 2025 Jan 17;14(1):3. DOI:10.1186/s40035-024-00464-3 2025
SARS-CoV-2 membrane protein induces neurodegeneration via affecting Golgi-mitochondria interaction [0.03%]
SARS-CoV-2膜蛋白通过影响高尔基体-线粒体相互作用诱导神经退行性病变
Fang Wang,Hailong Han,Caifang Wang et al.
Fang Wang et al.
Background: Neurological complications are a significant concern of Coronavirus Disease 2019 (COVID-19). However, the pathogenic mechanism of neurological symptoms associated with severe acute respiratory syndrome coronav...
N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson's disease [0.03%]
α-突触核蛋白N端检测揭示多系统萎缩和帕金森病中新的及更多样化的聚集形态
James A Wiseman,YuHong Fu,Richard L M Faull et al.
James A Wiseman et al.
Background: Parkinson's disease (PD) and multiple system atrophy (MSA) are classified as α-synucleinopathies and are primarily differentiated by their clinical phenotypes. Delineating these diseases based on their specif...
Endosomal traffic disorders: a driving force behind neurodegenerative diseases [0.03%]
溶酶体运输障碍：神经退行性疾病的重要驱动力
Jianru Dong,Weiwei Tong,Mingyan Liu et al.
Jianru Dong et al.
Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal transport is a critical process involved in the selective uptake, processing, and intracellular transport of substances. The equilibrium between en...