Targeted next-generation sequencing has comparable clinical value to metagenomic NGS for pulmonary infections in hematological malignancy patients: a real-world propensity score-matched study [0.03%]
针对血液系统恶性肿瘤患者肺部感染的靶向下一代测序与宏基因组测序具有相当的临床价值：真实世界倾向性匹配研究
Yulian Xiao,Yishu Tang,Yuhan Yan et al.
Yulian Xiao et al.
Background: Metagenomic next-generation sequencing (mNGS) is widely recognized in immunocompromised populations due to its unbiased ability to identify pathogens, while targeted next-generation sequencing (tNGS) combines ...
Diagnostic and therapeutic significance of exosomal miR-143-5p in the plasma of patients with rheumatoid arthritis [0.03%]
血清外泌体miR-143-5p在类风湿关节炎诊断和治疗中的意义研究
Ai-Yu Wu,Wan-Xia Wu,Ai-Zhen Chen et al.
Ai-Yu Wu et al.
Objective: This study aimed to evaluate the expression levels of exosomal microRNA (miRNA) in patients with rheumatoid arthritis (RA) and to assess the diagnostic and therapeutic significance of these biomarkers in the co...
Polygenic risk scores for Crohn's disease risk prediction in a Chinese population: insights from multi-ethnic genome-wide association studies [0.03%]
基于多民族全基因组关联研究的中国人群克罗恩病多基因风险评分遗传效应及预测性能研究
Liping Guan,Hankui Liu,Ningjing Zhao et al.
Liping Guan et al.
Crohn's disease (CD) is a chronic inflammatory bowel disease with a complex etiology involving genetic, immune, microbial, and environmental factors. Despite advances in understanding its pathogenesis, accurately predicting CD risk remains ...
Artificial intelligence performance in maxillary canine impaction: a systematic review [0.03%]
人工智能在上颌尖牙阻生中的表现：系统性回顾
Hassan Ahmed Assiri,Budur Khalid Alsaanah,Bushra Alshahrani et al.
Hassan Ahmed Assiri et al.
Objectives: This systematic review evaluates the literature to determine the usefulness and rules of artificial intelligence (AI) in the diagnosis and prediction of maxillary canine impaction (MCI). ...
Preoperative black line sign predicts progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fractures [0.03%]
术前黑线征提示骨质疏松性椎体压缩骨折经皮椎体成形术后可进展的后凸畸形
Lei He,Yi Hong,Zhenan Chen et al.
Lei He et al.
Objectives: This study aimed to evaluate the black line sign (BLS) on preoperative MR-STIR images as a predictor of progressive kyphosis (PK) following percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression...
Machine learning and SHAP values for predicting coronary artery disease risk in Xinjiang, China [0.03%]
机器学习和SHAP值在中国新疆预测冠心病风险
Gulinigaer Maimaitituersun,Fuerkaiti Abulimiti,Qiqi Shao et al.
Gulinigaer Maimaitituersun et al.
Background: Accurate individual risk assessment is crucial for guiding and improving the prevention of atherosclerotic cardiovascular disease (ASCVD). Existing prediction models are primarily derived from Western Caucasia...
Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses in melanoma [0.03%]
沉默髓样细胞白血病-1可改善黑色素瘤中的凋亡和铁死亡反应
Fang Fang,Qiuyun Xu,Shuyi Shen et al.
Fang Fang et al.
Background: Melanoma is a highly malignant skin cancer characterized by strong metastatic and invasive capabilities. Integrative transcriptomic profiling offers a systematic route to uncover tumor-specific regulatory hubs...
Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study [0.03%]
肌少症指数与骨关节炎的相关性：一项横断面及纵向研究
Xin Cai,Tianzuo Lan,Zong Jiang et al.
Xin Cai et al.
Background: The sarcopenia index (SI) is an accessible biomarker of muscle mass, yet its specific association with osteoarthritis (OA) remains unclear. This study aimed to evaluate this relationship both cross-sectionally...
IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial-mesenchymal transition process [0.03%]
白细胞介素36通过诱导上皮间质转化过程参与慢性哮喘模型气道重塑
Min Zhang,Jiemei Cen,Wenlei Gan et al.
Min Zhang et al.
Purpose: Epithelial-mesenchymal transition (EMT) is a major pathological characteristic of airway remodelling in severe asthma. Interleukin (IL)-36 belongs to the IL-1 family and is associated with allergic disease, but t...
Investigating the molecular mechanisms of glutamine metabolism and mitochondria-related biomarkers in Alzheimer's disease through transcriptomics and experimental validation [0.03%]
通过转录组学和实验验证调查谷氨酰胺代谢和与线粒体相关的生物标志物在阿尔茨海默病中的分子机制研究
Xiaying Si,Shihan Tian,Yudong Chen et al.
Xiaying Si et al.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. This study aims to identify biomarkers associated with glutamine metabolism-related genes (GRGs) and mitochondria-related genes (MRGs) in AD ...