MCT1 inhibition reprograms Treg metabolism via ABC transporters: implications for tumor immunity and the prognosis of acute myeloid leukemia patients [0.03%]
MCT1抑制通过ABC转运蛋白重新编程Treg代谢：对肿瘤免疫和急性髓系白血病患者的预后的影响
Ziyu Wang,Hongyang Wang,Qinghai Wang et al.
Ziyu Wang et al.
Glycolysis plays a critical role in regulatory T cells (Tregs), which are frequently exploited by tumor cells, as Treg survival depends on glycolytic activity to suppress antitumor immunity. However, the precise effects of glycolysis on Tre...
Delayed bedtime on workdays is associated with an increased prevalence of gallstones: a population-based study [0.03%]
上学日就寝时间推迟与胆结石患病率增加有关：一项基于人口的队列研究
Man Liu,Yanqing Gong,Yingxi Su et al.
Man Liu et al.
Objectives: The relationship between sleep and gallstones (GS) has rarely been reported. We aimed to investigate whether sleep traits are associated with the prevalence of GS. ...
Salvianolic acid B attenuates post-cardiac arrest cerebral ischemia-reperfusion injury via activation of the Nrf2 signaling pathway [0.03%]
救心草酸B通过激活Nrf2信号途径减轻心脏停搏后脑缺血再灌注损伤
Chuanbao Lv,Guangsheng Guo,Bao Feng et al.
Chuanbao Lv et al.
Background: Cerebral ischemia-reperfusion (CI/R) injury following cardiac arrest (CA) leads to profound neurological dysfunction driven by oxidative stress, inflammation, and apoptosis. Salvianolic acid B (SalB), a polyph...
Clinical value of sputum galactomannan testing in the diagnosis of invasive pulmonary aspergillosis among chronic obstructive pulmonary disease patients [0.03%]
慢性阻塞性肺疾病患者侵袭性肺曲霉病的临床诊断价值——痰GM试验 vs 影像学变化
Yi Lan,Hong Li,Dan Su et al.
Yi Lan et al.
Background: Diagnosing invasive pulmonary aspergillosis (IPA) in patients with chronic obstructive pulmonary disease (COPD) remains challenging due to the non-specific nature of imaging findings, the limited sensitivity o...
Integrative analysis reveals luteolin's molecular targets and mechanisms in pancreatic cancer treatment [0.03%]
整合分析揭示了芹菜素在胰腺癌治疗中的分子靶点和机制
Danhong Pan,Shixia Li,Peixi Zhong et al.
Danhong Pan et al.
Background: Pancreatic cancer remains one of the most lethal malignancies with limited therapeutic options. Luteolin, a natural flavonoid compound, has demonstrated potential anti-cancer properties, but its specific mecha...
Non-linear association between cardiometabolic index and helicobacter pylori infection: a cross-sectional study [0.03%]
卡代谢指数与幽门螺杆菌感染的非线性关联：一项横断面研究
Zhimao Cai,Hualang Cai,Dan Zhou et al.
Zhimao Cai et al.
Background: Helicobacter pylori (H. pylori) infection poses a significant global public health challenge. While prior studies have examined metabolic abnormalities in relation to H. pylori infection, the association betwe...
ARPC1B promotes gastric cancer tumorigenesis via IGF2BP3-mediated stabilization of HK2 mRNA and glycolytic reprogramming [0.03%]
ARPC1B通过IGF2BP3介导的HK2 mRNA稳定和糖酵解重编程促进胃癌的发生发展
Junjie Ma,Longyue Wang,Ting Liu et al.
Junjie Ma et al.
Background: Cancer cells improve survival through metabolic reprogramming, predominantly shifting to glycolysis. Actin-related protein 2/3 complex subunit 1B (ARPC1B) is abnormally overexpressed in multiple malignancies a...
Prognostic and predictive value of a novel immuno-proliferative biomarker signature for targeted therapy efficacy in non-small cell lung cancer [0.03%]
用于非小细胞肺癌靶向治疗疗效的新免疫增殖生物标志物谱的预后和预测价值研究
Wei Wei,Hongzhen Wang,Xin Han et al.
Wei Wei et al.
Background: Non-small cell lung cancer (NSCLC) is a prevalent and lethal malignancy. Although targeted therapies have improved clinical outcomes for patients with driver gene mutations, significant variability in treatmen...
Clinical spectrum, predictive biomarkers, and prognostic implications of peripheral neuropathies in primary Sjögren's syndrome: a retrospective cohort study [0.03%]
原发性舍格伦综合征外周神经病变的临床谱系、预测生物标志物和预后意义：一项回顾性队列研究
Yanqing Wang,Jincheng Pu,Fang Han et al.
Yanqing Wang et al.
Objective: Primary Sjögren's syndrome-associated peripheral neuropathy (pSS-PN) represents a clinically heterogeneous complication linked to significant morbidity. This study aims to characterize its prevalence, clinical...
Development of a novel rabbit auricle xenograft model of human PC3 prostate cancer [0.03%]
人PC3前列腺癌新型兔耳异种移植模型的建立
Xilong Yu,Heng Zhang,Jinlong Zhang et al.
Xilong Yu et al.
Background: Therapeutic management of prostate cancer remains challenging. Prostatic artery chemoembolization (PACE), an advanced minimally invasive technique derived from prostatic artery embolization (PAE), has shown pr...