Remimazolam alleviates hippocampal neuronal injury in an in vitro Alzheimer's disease model by promoting PINK1/Parkin-mediated mitophagy [0.03%]
瑞美扎莫缓解体外阿尔茨海默病模型中海马神经元损伤的作用及其机制研究
Wei Zhang,Bowen Shi,Yuanyuan Xie et al.
Wei Zhang et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the pathological accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau proteins. Remimazolam (RMZ), a novel ultra-short-acting benzodiazepi...
From "lysosomal addiction" to targeted therapies: exploiting novel windows in colorectal cancer [0.03%]
从“溶酶体上瘾”到靶向治疗：在结直肠癌中利用新靶点
Xiaoyu Wang,Fan An,Benjun Wang et al.
Xiaoyu Wang et al.
Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) face limited therapeutic options with conventional therapies, necessitating novel treatment strategies. CRC cells exhibit "lysosomal addiction" through enhanced aut...
Comparative impact of persistent and paroxysmal atrial fibrillation on myocardial strain: a retrospective cohort study [0.03%]
持续性和阵发性房颤对心肌应变影响的比较：回顾性队列研究
Hongru Chen,Lei Cheng,Wen Gao et al.
Hongru Chen et al.
Background: Atrial fibrillation (AF) impairs cardiac structure and function, increasing adverse cardiovascular outcomes. Myocardial strain analysis provides a sensitive measure of myocardial deformation and has emerged as...
Comparative Study
European journal of medical research. 2025 Oct 10;30(1):959. DOI:10.1186/s40001-025-03224-9 2025
Conjoint analysis of single-cell sequencing and high-throughput virtual screening regarding DDR2 in osteoarthritis disease models [0.03%]
基于单细胞测序和高通量虚拟筛选的OA疾病模型中DDR2联合分析
Hongliang Mei,Jiheng Wang,Xiaohu Zheng et al.
Hongliang Mei et al.
Osteoarthritis (OA) is a common degenerative joint disease, which is highly prevalent in the elderly, imposes a significant burden on patients and society. Aging, obesity, and inflammation are important factors contributing to the developme...
Cigarette smoke extract promotes metastasis and oxaliplatin resistance in colon adenocarcinoma through GDF15/ERBB2/AKT pathway [0.03%]
吸烟通过GDF15/ERBB2/AKT信号通路促进结肠癌的转移和奥沙利铂耐药性
Wen Jiang,Ye Wang,Wei-Jie Wang et al.
Wen Jiang et al.
Background: Colon adenocarcinoma (COAD) exhibits high mortality due to metastasis and oxaliplatin (L-OHP) resistance. Cigarette, an established environmental risk factor, is linked to poor prognosis in COAD, yet the under...
Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report [0.03%]
唾液作为潜在且无创性方法以识别T1DM共病相关上调基因的简短报告
Bashair M Mussa,Ankita Srivastava,Reeja Rajan et al.
Bashair M Mussa et al.
Background: One of the main challenges in Type 1 diabetes mellitus (T1DM) research is the sample size of the participants and the invasive process of collecting an adequate number of blood samples from young patients with...
Predictors of flexion contracture progression following total knee arthroplasty: role of global sagittal alignment and patient age [0.03%]
全膝关节置换术后屈曲挛缩进展的预测因素：全球矢状对齐和患者年龄的作用
Woo-Suk Lee,Byung Woo Cho,Hyuck Min Kwon et al.
Woo-Suk Lee et al.
Background: Knee flexion contracture (KFC) progression after total knee arthroplasty (TKA) can significantly affect functional outcomes through disruption of the biomechanical knee-hip-spine kinetic chain. This study was ...
Comprehensive analysis of real-world data on liraglutide treatment in patients with obesity: a multicenter national study [0.03%]
利拉鲁肽治疗肥胖患者真实世界数据的全面分析——一项全国多中心研究
Sema Hepşen,Cem Haymana,Burçak Cavnar Helvacı et al.
Sema Hepşen et al.
Background: The study aimed to evaluate real-world data on liraglutide by assessing its efficacy, associated side effects, adverse events, and impact on metabolic parameters within the context of a multicenter national st...
Observational Study
European journal of medical research. 2025 Oct 10;30(1):956. DOI:10.1186/s40001-025-02836-5 2025
Machine learning-based integration of pericoronary adipose tissue and clinical risk factors for cardiovascular risk prediction in type 2 diabetes: a retrospective cohort study [0.03%]
基于机器学习整合周围冠状动脉脂肪组织和临床危险因素以预测2型糖尿病患者心血管风险的回顾性队列研究
Yuqing Tang,Xuankun Zheng,Xiaofei Yang et al.
Yuqing Tang et al.
Background: Cardiovascular disease remains the predominant cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Traditional risk models are limited in predictive accuracy. Pericoronary adi...
Association between sleep duration and estimated glomerular filtration rate in Chinese patients with diabetes: evidence from a cross-sectional study [0.03%]
中国糖尿病患者睡眠时长与估算肾小球滤过率水平的关系：一项横断面研究证据
Cishuang Fu,Zhiming Deng
Cishuang Fu
Background: Previous epidemiological studies have demonstrated substantial associations between sleep duration and diabetes, vascular complications of diabetes, and cardiovascular disease in diabetic patients. However, fe...