The iron-ferroptosis axis in bone homeostasis: a potential complementary pathway for osteoporosis in endometriosis [0.03%]
铁/细胞铁死亡轴在子宫内膜异位症骨代谢稳态失衡中的作用及机制研究
Farzaneh Motafeghi,Fahimeh Ramezani Tehrani,Nasrin Ghassemi Barghi
Farzaneh Motafeghi
Endometriosis, a chronic gynecological disorder, is clinically associated with an increased risk of osteoporosis. While this link has been primarily attributed to hypoestrogenism resulting from the disease process or its treatment, this par...
Correlation between ambulatory blood pressure indices and sex hormone imbalance in hypertensive women with different menopausal durations: a cross-sectional study [0.03%]
不同绝经期持续时间的高血压女性24小时血压与性激素紊乱的相关性：横断面研究
Sijie Zhang,Heng Yu,Chenyang Jing et al.
Sijie Zhang et al.
Background: The prevalence of hypertension in postmenopausal women increases significantly compared to premenopausal women and gradually catches up with, or even exceeds, that of their male counterparts. Imbalanced levels...
Instrument-assisted soft tissue mobilization for musculoskeletal disorders: a systematic review and meta-analysis of its effects on pain, function, and range of motion [0.03%]
针对肌骨疾病的工具辅助软组织 Mobilization 系统评价及 Meta 分析：对疼痛、功能和关节活动度的影响
Yang Liu,Yueyong Yu,Panfeng Liu et al.
Yang Liu et al.
Background: Musculoskeletal disorders (MSDs) are a leading cause of global disability. This meta-analysis evaluated the efficacy of instrument-assisted soft tissue mobilization (IASTM) on pain, function, and range of moti...
A novel four-step protocol using intracavitary contrast-enhanced ultrasound combined with pelvic floor ultrasound for the diagnosis and preoperative planning of vesicovaginal fistulas [0.03%]
一种新的四步协议使用腔内对比增强超声联合盆底超声诊断和术前评估膀胱阴道瘘
Yelin Lou,Yang Hu,Tian Yang
Yelin Lou
Background: Vesicovaginal fistula (VVF) is a debilitating condition that significantly impairs quality of life. Accurate preoperative assessment of fistula characteristics is crucial for surgical planning. We aimed to eva...
Notch-1 suppressed vascular dementia via modulating AMPK/mTOR/TFEB/YAP signaling induced ferroptosis [0.03%]
NOTCH1通过调节AMPK/mTOR/TFEB/YAP信号诱导的铁死亡抑制血管性痴呆
Ling Zhu,Zhihuan Wu,Zhitao Zhang et al.
Ling Zhu et al.
Objective: The aim of this study is to clarify the molecular mechanism by which Notch-1 prevents vascular dementia (VD) by preventing ferroptosis caused by the AMPK/mTOR/TFEB/YAP pathway. ...
Diagnostic advantage of droplet digital PCR over blood culture in sepsis: a retrospective study of 115 patients [0.03%]
一项纳入115例患者的回顾性研究：在脓毒症中，液滴式数字PCR检测优于血液培养检测的优势
Xiaoqiong Yang,Zezhong Lv,Lan Zhang et al.
Xiaoqiong Yang et al.
Background: Sepsis is a life-threatening condition that requires rapid and accurate identification of causative pathogens to guide timely antimicrobial therapy. Blood culture is the current diagnostic standard, but it suf...
Prediction of cardiovascular mortality based on iron metabolism in patients with cardiovascular-kidney-metabolic syndrome: development and validation of clinical predictive model [0.03%]
基于心血管-肾脏-代谢综合征患者铁代谢的心血管死亡预测：临床预测模型的建立与验证
Ailifeire Aihaiti,Abulajiang Saidaming,Hasiyeti Tuerxun et al.
Ailifeire Aihaiti et al.
Background: Iron metabolism is associated with cardiovascular disease (CVD) mortality in patients with cardiovascular-kidney-metabolic (CKM) syndrome. However, its prognostic significance remains unclear. This study was a...
TMB-related immune gene PAEP influences clear cell renal cell carcinoma progression and prognosis [0.03%]
TMB相关免疫基因PAEP影响透明细胞肾细胞癌的进展和预后
Jie Yang,Guoliang Wu,Qian Wu et al.
Jie Yang et al.
Background: Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive form of kidney cancer with a poor prognosis. The tumor mutational burden (TMB) has been a subject of considerable interest in various cance...
Lactylation-driven gene signatures define breast cancer prognosis: a predictive model and insights into immune microenvironment dynamics [0.03%]
乳腺癌预后的乳酰化驱动的基因特征谱：预测模型及免疫微环境动态变化规律解析
Chao Li,Chao Hu,Xiandong Liu et al.
Chao Li et al.
Background: Breast cancer is a leading cause of cancer-related mortality worldwide, with poor prognosis largely due to its invasive and metastatic nature. Tumor lactylation plays a crucial role in cancer progression by in...
The molecular key in exercise-induced lung cancer prevention: insights from Mendelian randomization and SULT1A1-mediated mechanisms [0.03%]
运动诱导的肺癌预防的分子关键：来自孟德尔随机化和SULT1A1介导机制的启示
Shenyu Zhu,Qianshun Chen,Chen Huang et al.
Shenyu Zhu et al.
Background: Lung cancer is a leading cause of cancer-related mortality globally, yet its association with physical exercise remains incompletely understood. This study employed Mendelian randomization (MR) and bioinformat...