Unveiling sex-specific cardiometabolic and adiposity risk profiles for precision prevention [0.03%]
揭示性别特异性的心代谢和脂肪症风险谱以实现精准预防
Gianvincenzo Zuccotti,Paolo Osvaldo Agnelli,Lucia Labati et al.
Gianvincenzo Zuccotti et al.
Introduction: Cardiometabolic diseases (CMDs) are the leading global cause of mortality, driven by interrelated metabolic and cardiovascular factors. Sex differences significantly shape risk. We investigated sex-specific ...
A telomere-based prognostic model incorporating E2F1, MYCN, VPS72, CFAP53, OR8A1, and TXNRD1 for hepatocellular carcinoma [0.03%]
一种基于端粒的预后模型，结合E2F1、MYCN、VPS72、CFAP53、OR8A1和TXNRD1用于肝细胞癌
Yafei Wang,Leiya Fu,Zihan Yang et al.
Yafei Wang et al.
Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy associated with an unfavorable prognosis. Telomeres and telomere-related genes are central to tumorigenesis, but their systematic integration into pro...
Efficacy of the MIPO approach combined with inverted Philos plate fixation in the treatment of AO/OTA type 12B distal humeral shaft fractures [0.03%]
改良微创钢板接骨术结合倒置菲洛斯髓内钉治疗AO/OTA 12-B型尺骨近端骨折疗效分析
Lei Shen,Yong Wang,Chenjun Zhai et al.
Lei Shen et al.
Objectives: To investigate the clinical efficacy of the anterior minimally invasive plate osteosynthesis (MIPO) approach combined with the inverted proximal humeral internal locking system (Philos) plate in the treatment ...
Characterizing the molecular and clinical implications of NRG1 fusions in NSCLC through integrated RNA and DNA sequencing analysis [0.03%]
通过整合RNA和DNA测序分析描述NSCLC中NRG1融合的分子和临床意义
Yue Fan,Chenglu Zhang,Minyi Zhu et al.
Yue Fan et al.
NRG1 fusions are oncogenic drivers in non-small cell lung cancer (NSCLC), with therapeutic relevance highlighted by the FDA's designation of Zenocutuzumab for NRG1 fusion-positive cases. However, the molecular and clinical features of diffe...
Diagnostic accuracy of serum miR-23a-3p, miR-150, and miR-150-5p for diabetic osteoporosis in adults with type 2 diabetes: a retrospective single-center cohort study [0.03%]
成人2型糖尿病患者血清miR-23a-3p、miR-150和miR-150-5p诊断糖尿病性骨质疏松症价值的回顾性单中心队列研究
Huan-Shan Hong,Da-Qing Zhu,Li-Hui Kang et al.
Huan-Shan Hong et al.
Background: Diabetic osteoporosis (DOP) is a frequently under-recognized complication of type 2 diabetes (T2D). This study evaluated the association and diagnostic performance of serum miR-23a-3p, miR-150, and miR-150-5p ...
The association between blood urea nitrogen to serum albumin ratio and all-cause mortality in critically ill patients with atrial fibrillation [0.03%]
血尿素氮与血清白蛋白比率与房颤危重患者全因死亡率之间的关联性分析
Haosheng Wu,Xueqian Shen,Yu Xin et al.
Haosheng Wu et al.
Background: Blood urea nitrogen to serum albumin ratio (BAR) is an emerging biomarker that has been associated with sepsis, heart failure, and coronary artery disease. Nevertheless, few studies focus on its association wi...
miR-194-5p-mediated suppression of protein tyrosine phosphatase non-receptor type 12 (PTPN12) expression in the thymus enhances immunologic functional restoration in aged mice [0.03%]
miR-194-5p介导胸腺蛋白酪氨酸磷酸酶非受体类型12(PTPN12)表达抑制可增强老年小鼠免疫功能恢复作用
Ling-Yun Ai,Man-Qin Zhu,Wei-Man Xu et al.
Ling-Yun Ai et al.
Objective: This study aimed to explore the role of miR-194 in the post-transcriptional regulation of PTPN12 and its impact on age-related thymic atrophy. ...
Refining letermovir prophylaxis strategies and CD4 + T cell-guided discontinuation in aplastic anemia patients post-allogeneic HSCT: a retrospective analysis [0.03%]
基于allo-HSCT后再生障碍性贫血患者的回顾性分析精炼letermovir预防策略和CD4+T细胞指导的停药
Yuling Zhang,Xiaoqing He,Ming Zhou et al.
Yuling Zhang et al.
Introduction: Cytomegalovirus (CMV) infection is a significant complication in aplastic anemia (AA) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). While letermovir has shown efficacy i...
Unveiling the relationship between stress-hyperglycemia ratio and cardiometabolic multimorbidity risk using interpretable machine learning [0.03%]
利用可解释的机器学习揭示压力高血糖比率与心血管代谢多重疾病风险之间的关系
Shouxin Wei,Sijia Yu,Chuan Qian et al.
Shouxin Wei et al.
Background: Cardiometabolic multimorbidity (CMM) is the simultaneous manifestation of multiple cardiovascular and metabolic diseases, and it has arisen as a substantial worldwide healthcare issue. The stress-hyperglycemia...
Effects of atorvastatin on inflammatory markers, lipid profile, liver enzymes, and pulmonary function in patients with lung diseases: a systematic review and meta-analysis of randomized controlled trials [0.03%]
阿托伐他汀对肺病患者炎症标志物、脂质谱系、肝酶和肺功能的影响：随机对照试验的系统评价和meta分析
Samane Baseri,Morteza Izadi,Mina Alimohammadi et al.
Samane Baseri et al.
Background: Pulmonary diseases are important causes of morbidity globally. Atorvastatin's pleiotropic effects, which include anti-inflammatory and lipid-lowering properties, may be beneficial for individuals with respirat...