Hydrogels as advanced therapeutic delivery systems for improved cancer immunotherapy: current progress, challenges, and future prospects [0.03%]
水凝胶在癌症免疫治疗中的应用：进展、挑战与未来展望
Xiaohong Li,Kang Yang,Zebin Yang et al.
Xiaohong Li et al.
Immunotherapy has emerged as a new clinical paradigm for cancer management, leveraging immunomodulation to enhance systemic antitumor responses. Despite its significant potency and distinct advantages, challenges such as limited patient res...
Towards therapeutic applications of nanobody-Fc constructs: comparative analysis of Fc receptor binding and macrophage activation [0.03%]
纳米抗体-Fc融合分子的治疗应用初探——Fc受体结合和巨噬细胞活化的比较分析研究
Miglė Stančiauskaitė,Mantvydas Usvaltas,Kristina Mašalaitė et al.
Miglė Stančiauskaitė et al.
Nanobodies (Nbs) are new and promising tools for a variety of applications, including their use in medicine, although their functional activity and encounter with immune cells are still not well characterized. Our goal was to study the prop...
Comparative Study
Biomaterials science. 2026 Sep 29;14(19):5246-5264. DOI:10.1039/d6bm00509h 2026
Hydrogels and nanogels based on 2Nap-capped cationic tripeptides: influence of lysine position and siRNA delivery properties [0.03%]
基于2Nap-端基阳离子三肽的水凝胶和纳米凝胶：赖氨酸位置及siRNA递送性质的影响
Mariangela Rosa,Fin Hallam Stewart,Carlo Diaferia et al.
Mariangela Rosa et al.
The delivery of therapeutic short interfering RNA (siRNA) is hindered by biological barriers such as rapid degradation and poor cellular uptake. This study investigates peptide-based nanogels (NGs) as potential delivery platforms using thre...
Bacterial metabolism-activated turn-on fluorescent liposomal probe for diagnosing bacteria-associated tumors [0.03%]
用于诊断细菌相关肿瘤的开启式荧光脂质体探针：基于细菌代谢激活型
Siyu Zhang,Da-Yuan Wang,Xiaohan Tian et al.
Siyu Zhang et al.
Tumor-resident bacteria have emerged as key regulators of tumor progression, metastasis, and therapeutic resistance, yet their detection remains challenging because of their low abundance and predominantly intracellular localization. Here, ...
Dendrimers in precision oncology: advances in therapy, diagnostics, and translational prospects [0.03%]
树状分子在精准肿瘤学中的进展：治疗、诊断和转化前景
Davood Zaeifi,Khadijeh Jamialahmadi,Gholamreza Karimi
Davood Zaeifi
Dendrimers are highly branched nanoscale macromolecules with precisely tunable architectures that have emerged as transformative tools in cancer research. Their unique properties, such as high drug-loading capacity, multivalency, and surfac...
A double-amine ionizable lipid library enables highly efficient mRNA delivery to T cells at reduced lipid mass [0.03%]
双胺可离子化脂质文库可在降低脂质质量下实现向T细胞高效递送mRNA
Vishnu Sriram,Vidya Phatangare,Joo-Youp Lee
Vishnu Sriram
mRNA-based nucleic acid therapeutics have gained significant attention and undergone extensive clinical investigation since the FDA's approval of Spikevax and Comirnaty for the treatment of SARS-CoV-2. Lipid nanoparticles (LNPs) are current...
Sodium polyphosphate, a new drug for treatment of atopic dermatitis: basic considerations and clinical case studies [0.03%]
聚磷酸钠：治疗特应性皮炎的新药：基本考虑和临床病例研究
Meik Neufurth,Hadrian Nassabi,Sanja Perovic-Ottstadt et al.
Meik Neufurth et al.
Atopic dermatitis is a serious, chronic inflammatory skin disease that can currently only be treated symptomatically. The rise in extracellular Ca2+ ions by mast cells and platelets, which acts as a death signal for neuronal cells, plays a ...
Berk Akgün,Cagri Ayranci,Hasan Uludağ
Berk Akgün
Electrospun nanofiber mats are a versatile delivery system that can be applied locally at a target site, making them attractive for localized gene delivery. Although some studies reported electrospinning of nucleic acids, polyethylene oxide...
Dual delivery of metformin and doxorubicin via the gum acacia-gelatin nanohydrogel disrupts tunnelling nanotube-mediated breast cancer progression [0.03%]
gum acacia-明胶纳米水凝胶递送二甲双胍和多柔比星可破坏乳腺癌肿瘤隧道纳米管介导的癌细胞进展
Soumya Ranjan Jena,Anwesha Pradhan,Ganeswar Dalei et al.
Soumya Ranjan Jena et al.
Tunneling nanotubes (TNTs) are nano-scale intracellular conduits facilitating the transfer of cellular content. Intercellular communication between cancer cells via TNTs promotes invasion and metastasis. Given the important role of TNTs and...
pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy [0.03%]
响应pH的脂质体共递送膜活性肽和PI3Kγ抑制剂以重构肿瘤微环境用于增强抗肿瘤免疫治疗
Meng Li,Ying Li,Xiangyu Wu et al.
Meng Li et al.
Immunotherapy has shown enormous promise for cancer treatment, yet its efficacy is often hindered by the highly immunosuppressive tumor microenvironment (TME). Here, we developed a pH-responsive and cRGD-modified multifunctional liposomal s...