Biomimetic injectable methacrylated chondroitin sulfate-collagen hydrogels enhance chondrocyte function and promote osteochondral regeneration [0.03%]
甲基丙烯酰化硫酸软骨素-胶原水凝胶增强软骨细胞功能并促进骨软骨再生
Yining Yang,Yanni Li,Yu Zhang et al.
Yining Yang et al.
The development of biomimetic scaffolds capable of promoting both cartilage and subchondral bone regeneration remains a major challenge in osteochondral tissue engineering. In this study, type I acid-soluble collagen (ASC) was successfully ...
Vitronectin establishes a differentiation-restrictive extracellular microenvironment that sustains myoblast proliferation across species [0.03%]
补体蛋白vitronectin通过建立抑制分化细胞外微环境来跨物种维持成肌细胞增殖
Tomoka Katayama,Anmi Matsumoto,Yoka Takazawa et al.
Tomoka Katayama et al.
The extracellular matrix (ECM) critically regulates cell fate decisions, yet matrix components that actively impose differentiation-restrictive states remain insufficiently defined. Here, we identify vitronectin (VN), a major serum-derived ...
Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions [0.03%]
用于药物输送的弹性蛋白-胶原肽共轭物精细结构调节及其分子相互作用操控
Haofu Huang,Jingya Qin,Sirui Shen et al.
Haofu Huang et al.
Elastin-collagen nanoparticles (ECnPs) have been shown in our previous studies to self-assemble into different morphologies, including nanoplates and nanovesicles, by manipulating the sequence length of the elastin-like peptide (ELPs) and c...
A sulfonated diblock copolymer exhibits reversible antiplatelet activity and enables aqueous dipyridamole formulation [0.03%]
一种磺化嵌段共聚物具有可逆抗血小板活性并能够使双嘧达莫液体制备成为可能
Aleksandra Frackiewicz,Karol Depczynski,Magdalena Obłoza et al.
Aleksandra Frackiewicz et al.
Sulfonated block copolymers modulate biological function via charge-charge interactions. We report a sulfonated diblock copolymer - poly(sodium styrene sulfonate)-poly(sodium acrylamido undecanoate) (PSSNa38-b-PAaU10) with intrinsic charge-...
Mechanobiological regulation of endothelial vascularization after myocardial infarction: matrix mechanics, hydrogel strategies and applications [0.03%]
心肌梗死后内皮血管生成的机械生物学调节：基质力学、水凝胶策略及应用
Yanzhe Qian,Yuan Yao
Yanzhe Qian
Myocardial infarction (MI) triggers a wound-healing cascade that restores structural integrity but reshapes the cardiac mechanical microenvironment. The transition from compliant, healthy myocardium to stiff, fibrotic scar tissue creates bi...
Biomimetic characterization by micro-computed tomography (μCT) of 3D hollow fibre membrane network bioreactors for tissue engineering [0.03%]
显微计算机断层扫描（μCT）表征组织工程中三维中空纤维膜网络生物反应器的仿生特性
Giuseppe Falvo D&#x;Urso Labate,Chiara Morano,Thomas De Schryver et al.
Giuseppe Falvo D&#x;Urso Labate et al.
Hollow Fiber Membrane Bioreactors (HFMBs) support mammalian cell culture at high cell density by enabling effective transport of nutrients, gases and metabolites to/from cells and by offering high membrane surface area-to-bioreactor volume ...
Two-dimensional GeTe nanosheets for psoriasis through modulation of macrophage activation and psoriatic inflammation [0.03%]
二维GeTe纳米片通过调节巨噬细胞活化和银屑病性炎症治疗银屑病
Jieun Han,Ju-Won Kim,In Kang et al.
Jieun Han et al.
Psoriasis is a chronic inflammatory disease characterized by thickened erythematous skin lesions covered with white and silvery scales and accompanied by macrophage infiltration into the dermis. Although 2-3% of the world's population suffe...
Self-assembled biomimetic microenvironments with sulfated levan promote kidney epithelial cell growth and reduce inflammatory cytokine release [0.03%]
自组装的类硫酸化糖萼微环境促进肾上皮细胞生长并减少炎症因子释放
Dunya Arabi,Annika Clemenz,Cedric Wilden et al.
Dunya Arabi et al.
Kidney diseases are a major global health burden, underscoring the need for new strategies to support renal repair. Biomimetic materials that recapitulate extracellular matrix functions can provide structural support while presenting bioche...
Hydrogel-exosome synergistic system: mechanisms, applications and future prospects in regenerative medicine [0.03%]
水凝胶-外泌体协同体系在再生医学中的机制、应用及前景展望
Bin Xie,Yuyi Kang,Shuihao Zhao et al.
Bin Xie et al.
Hydrogels and exosomes are complementary and thus can be combined for regenerative medicine and emerging therapies. This strategy leverages the advantages of hydrogels to enhance the therapeutic potential of exosomes. Hydrogels offer numero...
Synergies of the submicron/microporous structures and gallium phytate coating on a polyetherketoneketone composite for facilitating synostosis and resisting infection [0.03%]
基于聚醚酮酮的复合材料中亚微米/微孔结构与镓植酸盐涂层的协同作用促进骨愈合和抗感染研究
Ping Sun,Ying Ye,Shangyu Xie et al.
Ping Sun et al.
Implant-related infections caused by invasion of bacteria is one of the most common complications during orthopedic interventions, and rapid synostosis is beneficial for stabilizing the implants and resisting infection. Herein, a niobium ox...