Haixue Jia,Qiang Fu,Dianyu Wang et al.
Haixue Jia et al.
Although cancer vaccines have been proposed for decades, their clinical outcomes have remained largely unsatisfactory. Over the past decade, progress in deciphering the interaction between the immune system and cancer, along with widespread...
Dual-functionalized GelFuMA hydrogel with sequential crosslinking for tunable mechanics and controlled drug release [0.03%]
具有顺序交联的双功能化GelFuMA水凝胶用于调节机械性能和控制药物释放
Farouk Segujja,Gökhan Duruksu,Yusufhan Yazır et al.
Farouk Segujja et al.
Articular cartilage repair is constrained by the tissue's low regenerative capacity, prompting the development of biomaterials that can integrate mechanical support with bioactive cues to modulate stem cell behavior. We report a dual-functi...
Host-directed antimicrobial peptide biomaterials for combating Gram-negative bacterial infections [0.03%]
用于对抗革兰氏阴性细菌感染的宿主导向抗菌肽生物材料
Muhammad Adil,Muhammad Arshad,Pengfei Zou et al.
Muhammad Adil et al.
Antimicrobial resistance (AMR) represents a defining crisis in modern infectious disease medicine. Gram-negative microbes such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae are becoming m...
TRPV-1-targeted Fe-phenolate network provokes apoptosis and ferroptosis to treat non-small cell lung cancer [0.03%]
靶向TRPV-1的Fe-酚基网络诱导非小细胞肺癌凋亡及铁死亡治疗非小细胞肺癌
Ziyi Wang,Liang Shao,Chunbao Wang et al.
Ziyi Wang et al.
Ferroptosis has emerged as a potential therapeutic target for chemotherapy of cancer. However, non-small cell lung cancer (NSCLC) exhibits high tolerance to ferroptosis due to inherent resistance. To increase NSCLC vulnerability, we present...
Effect of titanium-based anisotropic magnetic hydrogel coating on osseointegration [0.03%]
基于钛的各向异性磁性水凝胶涂层对骨结合的影响
Liu He,Jingxi Wang,Zengzilu Xia et al.
Liu He et al.
Titanium (Ti) implants suffer from elastic modulus mismatch with bone tissue, causing stress-shielding effects that lead to osteopenia and aseptic loosening. While hydrogel coatings have been explored to improve osseointegration, convention...
Stable, micron-scale lipocondensates achieving prolonged circulation without PEGlyated lipids [0.03%]
一种新型脂质纳米颗粒，在不使用聚乙二醇脂质的情况下实现稳定的微米级粒径及长时间循环能力
Chia-Wei Yeh,Chelsea A Loh,Lianne J Trigiani et al.
Chia-Wei Yeh et al.
Biomolecular condensates are key organizers of cellular biochemistry and are emerging as promising platforms for therapeutic delivery. However, how their molecular composition influences lipid organization and interfacial behavior remains p...
Fiber and continuum scale contributions to the intrinsic and apparent fracture of soft collagenous tissue via cutting [0.03%]
基于切割的软胶原组织固有断裂和表观断裂的纤维和连续体尺度贡献
Shaobo Zhan,Amy J Wagoner Johnson,Shelby B Hutchens
Shaobo Zhan
Soft collagenous tissues inspire material design because of their excellent fracture properties. Their fracture is integral to surgical procedures and unavoidable in many forms of trauma and disease, yet measuring it remains challenging. Sa...
Surface morphology-regulated tissue adhesion in solid and mesoporous silica-reinforced gelatin nanocomposite hydrogels [0.03%]
表面形态调节的固体和介孔二氧化硅增强明胶纳米复合水凝胶的组织粘附性
Khoa Diem Pham Huynh,Huyen Thanh Nguyen Anh,Chan Hung Nguyen et al.
Khoa Diem Pham Huynh et al.
Traditional wound closure methods often induce clinical complications such as pain and scarring, driving the urgent need for alternative bioadhesives that can seamlessly integrate robust mechanical integrity with superior wet-tissue adhesio...
Nanostructured hyaluronic acid-chia mucilage film as bioactive wound dressings for accelerated skin regeneration [0.03%]
纳米结构的透明质酸-奇亚黏胶膜作为生物活性伤口敷料促进皮肤再生
Thiyaneshwar Ramamoorthy,Renugaa Suresh Babu,Subastri Ariram et al.
Thiyaneshwar Ramamoorthy et al.
Scar formation after skin injury remains a major clinical challenge because most conventional wound dressings promote closure rather than tissue regeneration, often resulting in fibrosis. Although several biomaterials, such as collagen, chi...
Tunable bio-inspired hybrid hydrogels reprogram stem cell-derived extracellular vesicles for superior wound regeneration [0.03%]
一种可调的人工水凝胶能重编程干细胞来源的细胞外囊泡用于伤口愈合再生
Yen-Han Lai,Suhana,Su-Shin Lee et al.
Yen-Han Lai et al.
Clinical translation of adipose-derived stem cell (ADSC)-derived extracellular vesicles (EVs) for cutaneous regeneration is challenged by variable secretion levels, heterogeneous molecular cargo, and inconsistent therapeutic potency. Here, ...