Gina Turco
Gina Turco
The Pacific Symposium on Biocomputing (PSB) recognized my work with the 2024 Junior Research Parasite Award, an honor established to highlight the scientific value of reanalyzing, integrating, and reinterpreting existing datasets. The award...
Generalizable machine learning models for rapid antimicrobial resistance prediction in unseen healthcare settings [0.03%]
通用机器学习模型在未知医疗环境下的快速抗菌药物耐药性预测
Diane Duroux,Paul P Meyer,Giovanni Visoná et al.
Diane Duroux et al.
Background: The deployment of machine learning in clinical settings is often hindered by the limited generalizability of the models. Models that perform well during development tend to underperform in new environments, li...
Dynamont: A comprehensive cross-species comparison of ONT segmentation tools [0.03%]
Dynamont：ONT 前景分割工具的全面跨物种比较
Jannes Spangenberg,Christian Höner Zu Siederdissen,Winfried Goettsch et al.
Jannes Spangenberg et al.
Background: Oxford Nanopore Technologies (Oxford Nanopore Technologies (ONT)) sequencing enables direct, long-read sequencing of DNA and RNA, preserving nucleotide modifications. During basecalling, deep neural networks t...
Federated Knowledge Retrieval Elevates Large Language Model Performance on Biomedical Benchmarks [0.03%]
基于联邦知识检索的大型语言模型生物医学基准性能提升
Janet Joy,Andrew I Su
Janet Joy
Background: Large language models (LLMs) have significantly advanced natural language processing in biomedical research, however, their reliance on implicit, statistical representations often results in factual inaccuraci...
Cord blood DNA methylation and cell type composition are not significantly associated with severe preeclampsia, after cell type and clinical covariate adjustment [0.03%]
校正细胞类型和临床协变量后，脐带血DNA甲基化及细胞类型组成与重度子痫前期无显著关联
Xiaotong Yang,Wenting Liu,Zhixin Mao et al.
Xiaotong Yang et al.
Background: Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association analysis (EWAS) of preeclampsia produced inconsistent ...
Harnessing Artificial Intelligence for Genomic Variant Prediction: Advances, Challenges, and Future Directions [0.03%]
利用人工智能进行基因组变异预测：进展、挑战及未来方向
Indah Pakpahan,Mentari Sihombing,Haohan Liu et al.
Indah Pakpahan et al.
Accurate genetic variant interpretation is crucial for disease research and the development of targeted therapies. Artificial intelligence (AI) is transforming this field by integrating computational methodologies across structural biology,...
deMEM: a novel divide-and-conquer framework based on de Bruijn graph for scalable multiple sequence alignment [0.03%]
基于de Bruijn图的大规模多重序列比对的分而治之框架deMEM
Yanming Wei,Zhaoyang Huang,Pinglu Zhang et al.
Yanming Wei et al.
Background: Multiple sequence alignment (MSA) continues to be a central challenge in comparative genomics, where the quality of alignment plays a crucial role in determining the accuracy of downstream analyses. However, t...
Genome Assembly of Three Shrub Mangroves in the Genus Acanthus Reveals Two Polyploidy Events and Expansion of Genes Linked to Root Adaptation in Coastal Habitats [0.03%]
三种秋葵属红树 shrub mangrove 基因组的组装揭示了两次多倍体化事件以及与沿海生境根系适应相关基因的扩张
Wanapinun Nawae,Chaiwat Naktang,Peeraphat Paenpong et al.
Wanapinun Nawae et al.
The genomes of mangrove Acanthus species have not been reported, despite their ecological and medicinal importance. Using PacBio and Hi-C data, we generated a chromosome-scale genome assembly of the recently identified allotetraploid specie...
Joseph E Powell
Joseph E Powell
Large-scale single-cell genomics projects have revolutionised our understanding of human immune variation. Yet most studies to date have been Eurocentric, limited in cell-type resolution, or restricted to a single data modality. The newly p...
An evaluation of computational methods for reconstruction of human viral DNA genomes [0.03%]
评估用于重建人类病毒DNA基因组的计算方法
Maria J P Sousa,Mari Toppinen,Lari Pyöriä et al.
Maria J P Sousa et al.
Background: The increasing availability of viral sequencing data has led to the emergence of many optimized viral genome reconstruction tools. Given that the number of new tools is steadily increasing, it is complex to id...