Disha Tandon,Tarcisio Mendes De Farias,Pierre-Marie Allard et al.
Disha Tandon et al.
Background: In recent years, biodiversity data management has emerged as a critical pillar in global conservation efforts. Today, the ability to efficiently collect, structure, and analyze biodiversity data is central to ...
Integrative single-cell transcriptomics and proteomics reveal an immunometabolic framework for MSC-exosome-mediated remodeling of expanded NK cells [0.03%]
整合的单细胞转录组和蛋白质组揭示了MSC-外泌体介导的扩增NK细胞重塑的免疫代谢框架
Yunyun Fu,Yi Liu,Mingwen Xu et al.
Yunyun Fu et al.
Background: Natural killer (NK) cells play a central role in anti-tumor immunity and immunosurveillance of senescence, yet their clinical performance is frequently limited by functional exhaustion during ex vivo expansion...
Xiaoqiang Li,Cong Hua,Qian Yue et al.
Xiaoqiang Li et al.
GigaDB is a repository that links research articles with the underlying datasets, software, and metadata, helping to support open and reproducible research. As of February 2026, it contains 2,710 published datasets, covering 90.56 TB of dat...
Within-host diversity and phased variant analysis reveal structures and recombination of Helicobacter pylori subpopulations in stomach [0.03%]
胃内幽门螺旋杆菌亚群体的多样性及分型变异分析揭示了其结构和重组现象
Xiaomin Zhang,Hongjie Liu,Siyue Xu et al.
Xiaomin Zhang et al.
Helicobacter pylori (H. pylori) has a highly plastic genome and can generate substantial within-host diversity during chronic gastric colonization. However, the delineation of its within-host subpopulations, particularly regarding the emerg...
Learning inherent genetic patterns and trait associations with deep generative models for discrete genotype simulation [0.03%]
基于深度生成模型的学习固有遗传模式和特征关联性的离散基因型模拟方法
Sihan Xie,Thierry Tribout,Didier Boichard et al.
Sihan Xie et al.
Background: Deep generative models open new avenues for simulating realistic genomic data while preserving privacy and addressing data accessibility constraints. While previous studies have primarily focused on generating...
Georgios K Georgakilas,Brett Metcalfe,Ariane Bize et al.
Georgios K Georgakilas et al.
Background: As the technological advancements of the early 21st century are pushing industrial biotechnology (IB) into the realm of Big Data driven innovation, the requirement for trustworthy data management, annotation a...
Community-curated Galaxy interfaces with the Galaxy Labs Engine [0.03%]
基于Galaxy Labs Engine的社区精选Galaxy界面
Cameron J Hyde,Anna Syme,Bérénice Batut et al.
Cameron J Hyde et al.
The Galaxy platform is a globally distributed environment for data-intensive research, providing thousands of analysis tools across major public servers. However, this decentralised ecosystem presents usability challenges for both users and...
GEfetch2R: fetching single-cell/bulk RNA-seq data from public repositories to R and benchmarking the subsequent format conversion tools [0.03%]
GEfetch2R：从公共存储库获取单细胞/批量RNA测序数据到R，并对后续格式转换工具进行基准测试
Yabing Song,Jianbin Wang,Jiaxin Gao
Yabing Song
Background: Downloading and reanalyzing the existing single-cell RNA sequencing (scRNA-seq) data provides an efficient choice to gain clues and new insights. However, no tool can fetch the diverse scRNA-seq data types (ra...
HVRLocator: A Computationally Efficient Tool for Identifying Hypervariable Regions in Large 16S rRNA Datasets [0.03%]
高效识别大型16S rRNA数据集中高可变区的计算工具HVRLocator
Clara Arboleda-Baena,Felipe Borim Correa,Joao Pedro Saraiva et al.
Clara Arboleda-Baena et al.
Background: Metabarcoding of the 16S rRNA gene is widely used to assess microbial diversity due to its cost-effectiveness and efficiency. However, publicly available 16S rRNA metabarcoding datasets often lack standardized...
Comparative analysis of 163 ant genomes reveals recurrent horizontal gene transfer from bacteria to ants [0.03%]
对163个蚂蚁基因组的比较分析揭示了细菌到蚂蚁的重复水平基因转移现象
Janina L Rinke,Lukas Franke,Ding He et al.
Janina L Rinke et al.
Background: Horizontal gene transfer (HGT) from bacteria can drive phenotypic innovation and adaptation in eukaryotes. Ants are likely carriers of HGT-derived genes, as they have repeatedly established mutualistic associa...