Improved genome assembly of whale shark, the world's biggest fish: revealing intragenomic heterogeneity in molecular evolution [0.03%]
改进鲸鲨基因组组装：揭示分子进化中的内源性异质性
Yawako W Kawaguchi,Rui Matsumoto,Shigehiro Kuraku
Yawako W Kawaguchi
High-quality chromosome-level assemblies are essential for understanding genome evolution but remain difficult to obtain for large and complex genomes. Here we present a near gap-free genome assembly of the whale shark (Rhincodon typus) gen...
Single-nucleus multiple-organ chromatin accessibility landscape in the adult rat [0.03%]
成年大鼠单核多器官染色质可及性景观
Ronghai Li,Shanshan Duan,Qiuting Deng et al.
Ronghai Li et al.
The chromatin accessibility landscape is the basis of cell-specific gene expression. We generated a multi organ, single-nucleus chromatin accessibility landscape from the model organism Rattus norvegicus. For this single-cell atlas, we cons...
A Proposed Unified, Scalable Platform for Integrative Research on Venomous Species [0.03%]
venomous物种综合研究的统一可扩展平台构想
Shaadi Mehr,Todd Castoe,Marymegan Daly et al.
Shaadi Mehr et al.
Venomous animal research is hampered by fragmented, specialized, and non-interoperable databases (isolated genomic, proteomic, and ecological data). Despite the immense promise of venomous organisms to yield novel bioactive compounds for ph...
Expression-Driven Genetic Dependency Reveals Targets for Precision Oncology [0.03%]
基于表达的基因依赖性解析揭示精准肿瘤学靶点
Abdulkadir Elmas,Hillary M Layden,Jacob D Ellis et al.
Abdulkadir Elmas et al.
Background: Cancer cells are heterogeneous, each harboring distinct molecular aberrations and being dependent on different genes for their survival and proliferation. While targeted therapies based on driver DNA mutations...
ViralBindPredict: Empowering Viral Protein-Ligand Binding Sites through Deep Learning and Protein Sequence-Derived Insights [0.03%]
基于深度学习和蛋白质序列衍生信息的病毒蛋白-配体结合位点预测方法Virabindpredict
A M B Amorim,C Marques-Pereira,T Almeida et al.
A M B Amorim et al.
Background: The development of a single therapeutic compound can exceed 1.8 billion USD and take more than a decade, underscoring the urgent need to accelerate drug discovery. Computational methods have become indispensab...
High-definition likelihood inference of genetic colocalization reveals protein biomarkers for human complex diseases [0.03%]
高清晰度遗传共定位可能性推论发现人类复杂疾病蛋白生物标志物
Yuying Li,Ranran Zhai,Zhijian Yang et al.
Yuying Li et al.
Background: Genetic colocalization analysis is essential for understanding the shared genetic basis between phenotypic traits. Such an analysis is particularly useful for identifying plasma proteins with potential as ther...
nf-core/proteinfamilies: A scalable pipeline for the generation of protein families [0.03%]
nf-core/proteinfamilies：生成蛋白质家族的可扩展流水线
Evangelos Karatzas,Martin Beracochea,Fotis A Baltoumas et al.
Evangelos Karatzas et al.
The growth of metagenomics-derived amino acid sequence data has transformed our understanding of protein function, microbial diversity, and evolutionary relationships. However, the vast majority of these proteins remain functionally unchara...
MBGC2: Boosting compression via efficient encoding of approximate matches in genome collections [0.03%]
MBGC2：通过一组基因组中近似匹配的有效编码来提高压缩率
Tomasz M Kowalski
Tomasz M Kowalski
Background: FASTA is the primary format for representing DNA, RNA and protein sequences. While progress has been made in specialized FASTA collection compressors, they still struggle with practical limitations and inconsi...
SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets [0.03%]
基于贝叶斯融合方法的空间转录组数据共表达分析方法_spaceBF
Souvik Seal,Brian Neelon
Souvik Seal
Advances in spatial omics enable measurement of genes (spatial transcriptomics) and peptides, lipids, or N-glycans (mass spectrometry imaging) across thousands of locations within a tissue. While detecting spatially variable molecules is a ...
A preregistered, open pipeline for early cerebral palsy risk assessment from Infant Videos [0.03%]
婴儿期视频早期脑瘫风险评估的预注册、开放处理流程
Melanie Segado,Laura A Prosser,Andrea F Duncan et al.
Melanie Segado et al.
Cerebral Palsy (CP), affecting approximately 1 in 500 children due to abnormal brain development, impacts movement control. Early risk assessment via the General Movements Assessment (GMA) at 3-4 months is highly predictive for CP but relie...