What needs to be standardized for reliable, reproducible, and robust tractography? [0.03%]
可靠、可重复且稳健的轨迹跟踪需要哪些标准？
Jon Haitz Legarreta,Simona Schiavi,Wei Tang et al.
Jon Haitz Legarreta et al.
Tractography is a key component of efforts to map brain connectivity. As a rapidly-evolving field of neuroscience, current tractography methods are diverse, often varying across research laboratories and different software pipelines. Theref...
Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics [0.03%]
基于多维度转录组学的肿瘤免疫微环境中胶质母细胞瘤风险谱的研究
Tengyue Li,Wanqi Mi,Huarui Yan et al.
Tengyue Li et al.
Glioblastoma (GBM) is characterized by pronounced tumor heterogeneity and a complex immune microenvironment, contributing to poor patient survival outcomes. In this study, we comprehensively dissected the tumor microenvironment (TME) and un...
SMIntegration: A Web Tool for Comprehensive Spatial Metabolomics and Transcriptomics Integrated Analysis and Visualization [0.03%]
SMIntegration：一个全面的空间代谢组学和转录组学综合分析和可视化网络工具
Haoke Deng,Xiaolian Ning,Xun Lin et al.
Haoke Deng et al.
Current tools for spatial omics analysis often face challenges in performing integrated transcriptomics and metabolomics analysis, in-depth biological interpretation, and user-friendly operation. To address this, we developed SMIntegration,...
Sex Chromosome Turnover and Structural Genome Divergence Shapes Meiotic Outcomes in Hybridising Cobitis [0.03%]
性染色体转变和结构基因组分歧影响泥鳅属杂交种减数分裂结果
Stephen A Schlebusch,Vladimir Trifonov,Zuzana Halenková et al.
Stephen A Schlebusch et al.
Background: Hybridisation between divergent species can result in meiotic aberrations and the emergence of asexual reproduction. Yet, it remains poorly understood to what extent such outcomes arise from genome-wide incomp...
MADRe: Strain-level Metagenomic Classification Through Assembly-Driven Database Reduction [0.03%]
基于装配驱动数据库简化的菌株水平元基因组分类方法(MADRe)
Josipa Lipovac,Mile Šikić,Riccardo Vicedomini et al.
Josipa Lipovac et al.
Strain-level metagenomic classification is essential for understanding microbial diversity and functional potential, yet remains challenging, particularly when sample composition is unknown and reference databases are large and redundant. H...
Characterising a species-rich and understudied tropical insect fauna using DNA barcoding [0.03%]
采用DNA条形码技术研究物种多样性丰富且少有人问津的热带昆虫类群
David R Hemprich-Bennett,Ezekiel Donkor,Bernard Adams et al.
David R Hemprich-Bennett et al.
Background: West Africa has high biodiversity that is relatively understudied, especially for insects. Studies of West African arthropod diversity can therefore help address important questions regarding conservation, eco...
Multiplatform comparisons and annotation of structural variants highlight the utility of the T2T reference genome in human diagnostics [0.03%]
多平台比较和注释结构变异并突出T2T参考基因组在人类诊断中的实用性
Jakub Savara,Tomas Novosad,Petr Gajdos et al.
Jakub Savara et al.
Background: Structural variants (SVs) are increasingly recognised as key contributors to human diseases. However, our understanding of SVs in health and disease is limited, mainly due to their structural complexity and va...
ZNF331 Modulates Early Embryonic Transcription During Zygotic Genome Activation in Goat [0.03%]
ZNF331通过调控山羊卵裂球基因激活早期的转录发挥功能
Yingnan Yang,Jinhao Zhang,Xiaowei Chen et al.
Yingnan Yang et al.
Background: Zygotic genome activation (ZGA) is a pivotal process during early embryogenesis, marking the maternal-to-zygotic transition. ZGA is regulated by a variety of epigenetic and transcriptional factors. However, th...
Patterns of aDNA Damage Through Time and Environments - lessons from herbarium specimens [0.03%]
基于标本的古DNA损伤模式时空分布研究
Stefano Porrelli,Alice Fornasiero,Hong Phuong Le et al.
Stefano Porrelli et al.
Herbarium collections are a vast but underutilized resource for ancient DNA research, containing over 400 million specimens with detailed metadata and spanning centuries of global biodiversity. Understanding patterns of DNA preservation in ...
Toward total recall: Enhancing data FAIRness through AI-driven metadata standardization [0.03%]
向完美回忆迈进：通过人工智能驱动的元数据标准化来增强数据开放性、可查找性、互操作性和重用性
Sowmya S Sundaram,Rafael S Gonçalves,Mark A Musen
Sowmya S Sundaram
Scientific metadata often suffer from incompleteness, inconsistency, and formatting errors, which hinder effective discovery and reuse of the associated datasets. We present a method that combines Generative Pre-trained Transformer 4 (GPT-4...