Breaking the cold chain: solutions for room temperature preservation of mosquitoes leading to high quality reference genomes [0.03%]
突破冷链：为蚊子的室温保存寻找解决方案以获得高质量参考基因组
Fiona Teltscher,Petra Korlević,Edel Sheerin et al.
Fiona Teltscher et al.
Background: The Earth BioGenome Project (EBP) is a global endeavour to produce reference genomes for all described eukaryotic species. The majority of described species are arthropods, which tend to be small and require t...
PathoFact 2.0: An Integrative Pipeline for the Prediction of Antimicrobial Resistance Genes, Virulence Factors, Toxins and Toxin-associated Proteins, and Biosynthetic Gene Clusters in Metagenomes [0.03%]
PathoFact 2.0：预测元基因组中抗菌药物抗性基因、毒力因子、毒素和与毒素相关蛋白质及生物合成基因簇的集成流水线
Luis F Delgado,Júlia Ortís Sunyer,Cedric C Laczny et al.
Luis F Delgado et al.
Background: Antimicrobial resistance genes (ARG) and virulence factors (VFs) are central contributors to the global health crisis surrounding drug-resistant infections. ...
4D Single-Cell Spatial Transcriptomics Reveals Dynamic Morphogenetic Gradients and Regenerative Domains in Planarians [0.03%]
四维单细胞空间转录组学揭示了平面虫中的形态发生梯度和再生区域
Kai Han,Yuxiaofei Wang,Yao Li et al.
Kai Han et al.
Background: Understanding how organisms reconstruct complex tissue architectures following injury requires precise mapping of gene expression and cellular responses across space and time. Although planarians serve as a cl...
New causal discovery algorithm over censored variables identifies subtype-specific drivers of breast cancer progression [0.03%]
新的因果发现算法可在删失变量上运行，可识别出特定亚型的乳腺癌进展驱动因素
Tyler C Lovelace,Panayiotis V Benos
Tyler C Lovelace
Many research domains are producing large, multi-scale, multi-modal datasets at growing rates with mixed variable types (continuous, discrete, censored). Identifying possible cause-effect associations in such datasets is essential for predi...
Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer's and Parkinson's disease [0.03%]
细胞类型转录模块揭示了阿尔茨海默病和帕金森病共有的分子机制
Anwesha Bhattacharya,Edward A Fon,Alain Dagher et al.
Anwesha Bhattacharya et al.
Historically, Alzheimer's disease (AD) and Parkinson's disease (PD) have been investigated as two distinct disorders of the brain. However, a few similarities in neuropathology and clinical symptoms have been documented over the years. Trad...
Comparative Evaluation of Gene Selection Approaches in Transcriptomics: Bias Correction and Visualization with TransPro [0.03%]
转录组学中基因选择方法的比较评估：使用TransPro进行偏差校正和可视化
Dongyue Yu,Chen Li,Shuo Yan et al.
Dongyue Yu et al.
Background: Differential gene selection is fundamental to transcriptomics; however, mainstream methods typically fit each gene independently via marginal analyses. Although multifactor designs can be accommodated, gene-ge...
Leveraging Machine Learning and Network Biology Approaches to Predict Brain Gene Expression from Blood Transcriptomes [0.03%]
利用机器学习和网络生物学方法从血液转录组预测脑基因表达
Cigdem Sevim Bayrak,Qi Zeng,Marjan Ilkov et al.
Cigdem Sevim Bayrak et al.
Blood-based biomarkers offer a promising non-invasive strategy for detecting disease-related changes and monitoring tissue and organ health, including brain function. While recent studies have leveraged blood transcriptomic data to predict ...
Accurate proteome-wide prediction of enzymes and catalytic sites using graph deep learning and protein language model [0.03%]
基于图深度学习和蛋白质语言模型的精确全蛋白酶预测催化位点
Yui-Lun Ng,Xiaomei Wang,Yingqi Li et al.
Yui-Lun Ng et al.
Identifying the enzyme functions of proteins and their catalytic residues are vital to our understanding of diverse cellular processes. However, existing frameworks that can concurrently determine the enzymatic functions and active sites of...
Experimental and computational approaches for deep metabolome annotation with application to the ecotoxicological model organism Daphnia magna [0.03%]
应用于生态毒理模型生物Daphnia Magna的深度代谢组注释实验和计算方法研究
Thomas N Lawson,Martin R Jones,Andrew J Chetwynd et al.
Thomas N Lawson et al.
Background: Comprehensively characterising the metabolomes of model organisms with high coverage and confidence is a critical step towards interpreting the metabolic basis of human and environmental health, yet there are ...
Draft assemblies for 177 bird species enhance genus-level coverage [0.03%]
177种鸟类的草图基因组提升了鸟类属水平的基因组覆盖度
Guangji Chen,Shuang Wang,Daniel Bilyeli Øksnebjerg et al.
Guangji Chen et al.
Background: With over 10,000 recognized species, birds constitute one of the most diverse and widely distributed vertebrate groups. Although avian genomics has advanced rapidly over the past decade, substantial gaps remai...