GSK3i combinatorial treatments affect CDK4/6 and compensatory pathways in 3D preclinical models of pancreatic neuroendocrine tumors [0.03%]
GSK3i联合用药影响胰腺神经内分泌肿瘤三维临床前模型中的CDK4/6和补偿途径
Edlira Luca,Igor Shapiro,Huguette Debaix et al.
Edlira Luca et al.
Pancreatic neuroendocrine tumors (pNETs) are rare tumors, often detected at advanced stages for which current therapies are mostly unsuccessful. Despite significant progress in the understanding of pathogenic molecular pathways, most single...
Phenotypic plasticity shapes carry-over effects in sea rock-pool mosquitoes [0.03%]
表型可塑性影响海岩池蚊虫的连锁效应
Giulia Cordeschi,Roberta Bisconti,Valentina Mastrantonio et al.
Giulia Cordeschi et al.
Environmental conditions during early life can shape trait expression after metamorphosis. Direct carry-over effects occur when the value of a trait expressed at an early stage directly determines its expression at later stages, maintaining...
An ARVC-5 Drosophila knock-in model reveals new functions of Tmem43 in lipid homeostasis [0.03%]
TMEM43动脉肌病小鼠模型揭示其在脂质稳态中的新功能
Kai Jürgens,Lena Menzel,Nora Klinke et al.
Kai Jürgens et al.
Arrhythmogenic right ventricular cardiomyopathy type 5 is caused by the missense mutation S358L in the gene TMEM43 in humans. To date, the molecular mechanisms underlying the disease remain poorly understood. We established a CRISPR/Cas9 kn...
Assessing frailty in aged zebrafish using a quick pseudo-frailty index [0.03%]
利用快速pseudo-脆弱指数评估老龄斑马鱼的脆弱性
Anne Cathrine Hyde,Pamela Ellis,Sherif El-Khamisy et al.
Anne Cathrine Hyde et al.
While biomedical advancements have significantly extended human longevity, increased lifespan is frequently decoupled from healthspan, as these additional years are often accompanied by frailty and chronic morbidity. Frailty is characterize...
What impact do new homologs have on detecting interdomain horizontal gene transfer in eukaryotes? A reassessment of Katz (2015) [0.03%]
新直系同源基因对在真核生物中检测跨域水平基因转移的影响几何——兼评Katz(2015)论文
Kevin Aguirre-Carvajal,Vinicio Armijos-Jaramillo
Kevin Aguirre-Carvajal
The role of interdomain horizontal gene transfer (iHGT) in eukaryotic genome evolution remains a subject of ongoing debate. Numerous studies have reported prokaryote-to-eukaryote transfer events, yet the extent to which these inferences are...
Marcela Xiomara Rivera Pineda,Jaakko Lehtimäki,Guillaume Jacquemet
Marcela Xiomara Rivera Pineda
Accurate and reproducible orientation of zebrafish larvae is essential for high-resolution live imaging but remains difficult with standard agarose mounting. Although previous methods have used 3D-printed tools, often fabricated via stereol...
Increasing temperature exacerbates acute toxicity effects of a glyphosate-based herbicide (Roundup) on the ostracod Cypridopsis africana [0.03%]
温度升高加剧了基于草甘膦的除草剂（Roundup）对枝角类动物Cypridopsis africana急性毒性效应
Yusuph A Kafula
Yusuph A Kafula
Predicted global temperature increase is expected to have unprecedented effects on freshwater ecosystems. While individual impacts of temperature and chemical exposures on aquatic species physiology, life history and survival has received a...
Loss of sphingomyelin synthase-1 does not cause egg retention or locomotion defects in Caenorhabditis elegans [0.03%]
Caenorhabditis elegans中鞘氨醇基磷脂酰胆碱合成酶-1的缺失不引起卵保留或运动缺陷
Wenyue Wang,Xiaoyan Gao,Roger Pocock
Wenyue Wang
Sphingomyelin is a critical sphingolipid found in plasma membranes of metazoa that provides structural and communicative functions. Sphingomyelin synthases are key enzymes that generate sphingomyelin but their precise functions in animal de...
Aliyah R Goldson,Jacob Hudock,Justin W Kenney
Aliyah R Goldson
Consistent individual differences in behavior are prevalent throughout the animal kingdom and are thought to be important contributors to evolutionary adaptation. However, the biological basis for individual differences are poorly understoo...
Fostering the next generation of bone marrow adiposity researchers: the 3rd International Bone Marrow Adiposity Society Summer School 2025 report [0.03%]
第三届国际骨髓脂肪学会暑期学校2025报告：培育下一代骨髓脂肪研究人员
Drenka Trivanović,Tânia Amorim,Adriana Roque et al.
Drenka Trivanović et al.
The 3rd International Bone Marrow Adiposity Society (BMAS) Summer School 2025 gathered young basic and clinical researchers to advance their knowledge of bone marrow adipose tissue (BMAT). The virtual BMAS Summer School 2025 consisted of pa...