Dkk1 inhibition restores mandibular growth in an achondroplasia mouse model [0.03%]
DKK1抑制在软骨发育不全小鼠模型中恢复下颌生长
Briantana Raveendranathan,Valentin Estibals,Eric Pulido et al.
Briantana Raveendranathan et al.
Meckel's and condylar cartilages are key to mandible development, with Meckel's cartilage acting as a template and condylar cartilage as a growth center. In achondroplasia, the most common form of genetic dwarfism, abnormalities of these ca...
StrIPETrack: a real-time, ROI-flexible tracking platform for high-throughput zebrafish behavior [0.03%]
Stripetrack：一种用于高通量斑马鱼行为分析的实时ROI可调跟踪平台
Camden E Cummings,Brandon L Bastien,Jaqueline A Martinez et al.
Camden E Cummings et al.
Quantitative phenotyping is essential to studies of animal behavior, enabling systematic analysis of variation arising from natural diversity or experimental manipulation. High-throughput behavioral assays that can simultaneously test multi...
Katherine Brown,Daniel Gorelick,Alejandra Clark
Katherine Brown
Riku O Korkiamäki,Chandan Thapa,Hannah J Green et al.
Riku O Korkiamäki et al.
Mechanosensing involves proteins detecting mechanical changes in the cytoskeleton or at cell adhesion sites. These interactions initiate signaling cascades that produce biochemical effects such as post-translational modifications or cytoske...
Daniel Gorelick
Daniel Gorelick
Background colour preference in juvenile European lobster (Homarus gammarus) [0.03%]
欧洲小圆蛤(Homarus gammarus)的背景颜色偏好
Matt E Bell,Nicholas Kuvaldin,Erik Romero Frontaura et al.
Matt E Bell et al.
The European lobster (Homarus gammarus) is a commercially valuable species under pressure from overfishing, climate change, and offshore developments. As hatchery-based restocking and aquaculture expand, optimising artificial rearing condit...
Precious O Owuamalam,Md Nazmul Hossain,Saverio Brogna
Precious O Owuamalam
Nonsense mutations are often associated with reduced mRNA levels, as premature translation termination can lead to the activation of nonsense-mediated mRNA decay (NMD). To examine how positional context influences these outcomes, we introdu...
Identification and validation of an interaction between the E3 Ubiquitin Ligase WWP1 and the transcriptional co-activator WBP2 in the human heart [0.03%]
人WWP1泛素连接酶与转录共激活子WBP2在心脏中的相互作用的鉴定和验证
Meaghan E Arnold,Ymani Wright,Natalie K Grantham et al.
Meaghan E Arnold et al.
Impaired proteostasis is a cellular hallmark of aging, and the ubiquitin-proteosome system is a fundamental driver of proteostasis. As an E3 ubiquitin ligase, WW-domain containing protein 1 (WWP1) expression and activity are tightly regulat...
Enhancer of zeste homolog 2 (Ezh2) is required in mouse Isl1-expressing progenitors for proper development of cardiac and skeletal hindlimb structures [0.03%]
EZH2在Isl1表达的前体细胞中对心脏和后肢骨骼的正常发育是必需的
Hamna Ammar,Daniel B Patolsky,Lijun Chi et al.
Hamna Ammar et al.
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2, catalyzes H3K27 trimethylation and directs lineage development programs, yet its function in early multipotent progenitors remains incompletely unde...
Ralf Kölling
Ralf Kölling
Here we analyzed the recycling of the Vps55/Vps68 complex in the yeast endocytic pathway. The two proteins seem to form a functional unit. Single deletions of VPS55 or VPS68 affected the turnover of the endocytic cargo protein Ste6 to the s...