Cat brains age like humans: Translating Time shows pet cats live to be natural models for human aging [0.03%]
猫的大脑像人类一样衰老：时间转化显示宠物猫可以成为人类衰老的自然模型
Capucine Januel,Elijah Morrow,Ryan Gibson et al.
Capucine Januel et al.
Whether an animal can achieve a lifespan equivalent to a human in their 80s remains an open question. Cats may serve as valuable models for human aging because there is some evidence that they can develop human related aging patterns. Here,...
Conserved roles of GATA4 and its target gene TBX2 in regulation of human cardiogenesis [0.03%]
GATA4及其靶基因TBX2在人类心脏生成中的保守调节作用
Nicola Graham,Pavel Kirilenko,Ilya Patrushev et al.
Nicola Graham et al.
The transcription factor (TF) GATA4 is a key mediator of cardiogenesis. GATA4 regulates cardiogenesis through the expression of its target genes, only some of which have been identified. We have used a gain of function model based on plurip...
Kinetic properties of optogenetic site-specific DNA recombination by LiCre-loxP [0.03%]
LiCre-LOXP光控位点特异性重组的的动力学性质研究
Alice Dufour,Hélène Duplus-Bottin,Thomas Boukéké-Lesplulier et al.
Alice Dufour et al.
Advances in optogenetics now allow specific modifications to the DNA of live cells with light. However, successfully using these technologies requires knowing their properties in terms of sensitivity, efficiency, kinetics and mechanism. We ...
Meeting Review of the Cryospheric Ecosystems Conference, 1-4 September 2025, Poznań, Poland [0.03%]
波兰波兹南召开的 cryosphere 生态系统大会会议回顾（2025年9月1-4日）
Kinga Skoczeń,Zofia Kujawa,Magdalena Strawa et al.
Kinga Skoczeń et al.
The Cryospheric Ecosystems Conference, held at Adam Mickiewicz University in Poznań from September 1 to 4, 2025, brought together 80 scientists, researchers, and students from 15 countries. The conference was held as part of the Internatio...
Profiling cell proliferation after whole-genome duplication in human cells [0.03%]
人细胞中全基因组复制后 profiling 细胞增殖
Guang Yang,Masaya Inoko,Kaito Ogura et al.
Guang Yang et al.
Though whole-genome duplication (WGD) contributes to cancer progression, the mechanism of post-WGD cell proliferation remains unclear. Here, using 6-day live-imaging, we analyzed the proliferation dynamics of more than 150 post-WGD HCT116 c...
Shifting paradigms: phosphatases from basic biology to druggable targets [0.03%]
从基础生物学至药物靶点的酪氨酸磷酸酶研究范式的转换
Catia L Pierotti,Marian Brenner,Yamini Chand et al.
Catia L Pierotti et al.
The EMBO Workshop 'Phosphatases: from basic research to translation' (27 to 31 July 2025, Würzburg, Germany) brought together researchers from academia and industry for a deep dive into the rapidly evolving world of phosphatase biology. Ov...
Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure [0.03%]
通过特定的鞘脂结构缺陷解耦营养感应和细胞大小控制
José Ignacio Quesada-Márquez,Ana Serrano,María Alcaide-Gavilán et al.
José Ignacio Quesada-Márquez et al.
Ceramides are essential structural lipids whose chemical diversity arises from variations in acyl-chain length and sphingoid-base modifications, yet how these structural features couple metabolic state to growth regulation remains unclear. ...
Computer vision analysis to identify episodic flapping in hovering hummingbirds [0.03%]
计算机视觉分析识别盘旋蜂鸟的拍打翅膀模式
Maria Ximena Bastidas-Rodriguez,Ana Melisa Fernandes,María José Espejo Uribe et al.
Maria Ximena Bastidas-Rodriguez et al.
Hummingbirds hover, enabling them to serve as exclusive pollinators for many plant groups with which they have coevolved. They combine bird muscle power with insect flight skills to hover and maneuver in any direction. This study investigat...
Live-cell tracking of biliverdin trafficking reveals metabolic exchange between plastids and peroxisomes [0.03%]
活细胞示踪检测到血绿素转运现象表明叶绿体和过氧化物酶体之间存在代谢交换
Mone Shibata,Keiji Yoshida,Hitomi Takahashi et al.
Mone Shibata et al.
Metabolite trafficking between organelles is widespread, yet many trafficking routes remain poorly understood. Biliverdin (BV), a tetrapyrrolic pigment, is involved in redox and light signaling in animal and plant cells. To visualize the in...
Severe hypoxia drives loss of ST6GAL1-mediated α2,6-sialylation in the epicardial secretome impairing angiogenic activity [0.03%]
严重的缺氧通过抑制ST6GAL1介导的α2,6-唾液酸化作用而导致心外膜分泌组分中血管生成活性下降
Junqing Zhang,Harry J Whitwell,Costanza Emanueli et al.
Junqing Zhang et al.
The epicardium contributes to cardiac development and regeneration, primarily through paracrine signalling. However, the impact of severe hypoxic stress, such as occurs immediately following myocardial infarction, on the activity of the epi...