Allometric scaling and social modulation of resting metabolic rate in a eusocial mammal (Heterocephalus glaber) [0.03%]
社交调节异头鼠（Heterocephalus glaber）的全ometric生长和静息代谢率
Jack E Thirkell,Chris G Faulkes,Hana N Merchant et al.
Jack E Thirkell et al.
Resting metabolic rate (RMR) underpins energy allocation to survival, reproduction, and longevity, yet its drivers in highly structured social systems remain unclear. We measured RMR in 76 naked mole-rats (Heterocephalus glaber) from five c...
Fructose impairs brown adipogenesis by promoting thyroid hormone resistance in differentiated brown adipocytes [0.03%]
果糖通过促进甲状腺激素抵抗抑制棕色脂肪细胞褐脂生成作用
Xiangdong Wu,Salaheldeen Elsaid,Lei Zhang et al.
Xiangdong Wu et al.
Excessive fructose consumption is increasingly linked to obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease, yet its impact on brown adipocytes remains poorly defined. Here, we investigated how fructose...
FlyClimber: a new user-friendly, automated method to measure Drosophila motor coordination [0.03%]
FlyClimber：一种新的用户友好的、自动化的果蝇运动协调测量方法
Callan Sharples,Petros Ligoxygakis
Callan Sharples
The climbing assay, used to assess locomotive capabilities of Drosophila, takes advantage of the negative geotropism reflex. After a vial is knocked at the bench and flies are brought down to the bottom by that movement, they exhibit the in...
Norma Martínez-Lendech,Ivette Marai Villa-Villaseñor,Luis Felipe Mendoza-Cuenca et al.
Norma Martínez-Lendech et al.
Parental care involves post-zygotic behaviors that promote offspring survival but can diminish parental survival and future reproductive potential. Although care is typically shared, males and females often differ in its nature and intensit...
Preparation of soluble and functional recombinant HTLV-1 Tax protein using bacterial chaperones [0.03%]
利用细菌分子伴侣表达高活性的人类T细胞白血病病毒蛋白Tax
Michi Miura,Kazutaka Murayama,Satoshi Uemura et al.
Michi Miura et al.
HTLV-1 viral protein Tax physically interacts with multiple host proteins to disrupt their normal functions, causing debilitating haematological malignancy and inflammatory disorders. The recombinant Tax protein, like other intrinsically di...
Interferon signaling is required for early neutrophil recruitment after zebrafish heart injury [0.03%]
干扰素信号在斑马鱼心脏损伤后早期中性粒细胞募集过程中是必需的
Alexis V Schmid,James A Gagnon
Alexis V Schmid
Heart injury triggers a robust cellular response in zebrafish, characterized by neovascularization, immune cell activation, and the infiltration of proliferative cardiomyocytes that collectively lead to scarless regeneration. Upon injury, d...
AXL receptor tyrosine kinase regulates Golgi organization and function via an adhesion-Arf1 signalling axis in breast and lung cancer cell lines [0.03%]
AXL受体酪氨酸激酶通过粘附-Arf1信号轴调节乳腺癌和肺癌细胞系的高尔基复合体组织与功能
Prachi Joshi,Arnav Saha,Radhika Malaviya et al.
Prachi Joshi et al.
Cell-matrix adhesion regulates membrane trafficking, Golgi organization, and function. Altered Golgi organization in cancer cells may influence trafficking and cargo processing. A simple screen revealed distinct, adhesion-dependent differen...
Worms about town: a citizen science project discovers microsporidian parasites of nematodes through environmental sampling [0.03%]
城市中的蠕虫：一项公民科学项目通过环境采样发现了线虫的微孢子虫寄生虫
Jonathan Tersigni,Edward B James,Aaron W Reinke
Jonathan Tersigni
Microsporidia are a diverse group of fungal parasites that infect humans and agriculturally important animals. Caenorhabditis elegans has emerged as a powerful host for investigating microsporidian biology, yet how ecological factors such a...
Glimpse into the role of Kupffer cells in a spheroid model of metabolic dysfunction-associated steatohepatitis (MASH) [0.03%]
代谢功能紊乱相关肝炎(MASH)球体模型中枯氏细胞作用的初步研究
Niklas Bogovic,Maria Drießlein,Marie Keller et al.
Niklas Bogovic et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), are characterized by lipid accumulation, inflammation, and fibrosis. Existing preclinical mo...
Visualization of peripheral nerves in developing and regenerating limbs using a novel peripherin reporter line of Xenopus laevis [0.03%]
使用新型peripherin报告基因系在非洲爪蟾发育和再生 limb中可视化外周神经
Miyuki Suzuki,Yosuke Kato,Rima Mizuno et al.
Miyuki Suzuki et al.
Peripherin (PRPH) is a class III intermediate filament protein expressed in peripheral nerves and upregulated during axon outgrowth and regeneration. In this study, we developed a transgenic Xenopus laevis line for long-term in vivo visuali...