Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells? [0.03%]
组蛋白基因表达装置的功能组件会被功能重构以适应终末分化细胞的需要吗？
Xiao-Cui Yang,Anthony Desotell,Agata Malinowska et al.
Xiao-Cui Yang et al.
The expression of metazoan replication-dependent histone genes is controlled by NPAT and U7 snRNP. NPAT activates transcription of histone genes during S-phase, whereas U7 snRNP is a multi-subunit endonuclease that cleaves the resultant tra...
Maternal obesity in rats results in male-specific increases in genome-wide DNA methylation in postnatal offspring liver [0.03%]
孕期肥胖可导致大鼠子代产后肝脏基因组范围内的DNA甲基化性别差异表观遗传重编程
Neil A Youngson,Susan M Corley,Kyoko Hasebe et al.
Neil A Youngson et al.
Male-specific peripubertal DNA demethylation in the liver has been reported in mouse. Here we investigated whether it also occurs in rats, the influence of maternal obesity and whether DNA demethylation changes contribute to observed sex-sp...
Is the developmental stage important for the plasticity of transgenerational immune priming? [0.03%]
发育阶段对跨世代免疫启动的可塑性重要吗？
Fernanda Vázquez-Fuerte,Angélica González Hernández,Juan Carlos Torres Guzmán et al.
Fernanda Vázquez-Fuerte et al.
Parental transfer of immune memory can increase offspring survival, although its benefits may vary across developmental stages. We investigated transgenerational innate immune priming in the fall armyworm (Spodoptera frugiperda) infected wi...
Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC derived cardiomyocytes [0.03%]
拓扑特满和TOP2B敲低对诱导多功能干细胞来源心肌细胞基因表达影响的分析研究
Veronika Kerestes,Ian Cowell,Anna Jirkovska et al.
Veronika Kerestes et al.
The role of DNA topoisomerase II beta (TOP2B) in cardiomyocyte differentiation is poorly understood. To address this, Human induced pluripotent stem cells (hiPSC) were differentiated into cardiomyocytes (CM) that are wildtype or contain a g...
The extracellular protease AdamTS-B is a dosage-sensitive regulator of unicellular tracheal branch morphogenesis [0.03%]
胞外蛋白酶Adamts-B是以剂量依赖方式调控单细胞气管分支形态发生的调节因子
Abigail Thuringer,Elizabeth Steinmetz,Muna Abdullahi et al.
Abigail Thuringer et al.
Epithelial tube morphogenesis requires coordinated interactions between epithelial cells and their extracellular environment, yet the extracellular mechanisms that regulate this process remain poorly understood. The Drosophila trachea provi...
No evidence for aversive associative olfactory memory through metamorphosis in Drosophila [0.03%]
果蝇不会通过变态形成厌恶的条件气味记忆
Haiko Poppinga,Rotem Mika,Maria Schwartz et al.
Haiko Poppinga et al.
Do memories acquired through learning by insects in the larval stage persist throughout metamorphosis into adulthood? There are contradictory reports to answer this question. After a larval stage, holometabolous insects undergo pupation and...
Prey capture strategies relate to prey position in the scale-eating cichlid Perissodus microlepis [0.03%]
猎物位置影响丽鱼科鱼类捕食策略
Kai Koike,Matasaburo Fukutomi,Yuichi Takeuchi
Kai Koike
Predators have evolved sophisticated behavioral patterns that enable efficient prey capture. The scale-eating cichlid Perissodus microlepis exhibits pronounced morphological asymmetry in mouth-opening direction, corresponding to behavioral ...
Daniel T Burns,Ken G Gerow
Daniel T Burns
Repeated measures designs are a common experimental setup in biology, from ecology to biomedical sciences. Traditional statistical techniques for analyzing such data, such as repeated measures ANOVA (RMANOVA), have limitations that prevent ...
A Proximity ligation screen identifies snat2 as a novel target of the MARCH1 E3 ubiquitin ligase [0.03%]
邻近连接筛选识别出MARCH1 E3泛素连接酶的新靶点snat2
Renaud Balthazard,William Mitchell,Maxime Raymond et al.
Renaud Balthazard et al.
E3 ubiquitin ligases include hundreds of members that can regulate the half-life of other proteins, but also modulate their cellular localization and functions. While MARCH1 appears to target principally immune cell components, such as MHC ...
A Python-based automated pipeline for phylogenetic tree construction, visualization, and comparative statistical evaluation [0.03%]
一种基于Python的用于系统发育树构建、可视化和比较统计评估的自动化流水线
Bhavika Gambhava,Janvi Patel,Niyati Buch
Bhavika Gambhava
Phylogenetic analysis is a fundamental concept in computational biology, which helps in understanding evolutionary relationships, species divergence, and functional conservation based on biological sequence data. In general, phylogenetic an...