Developmental and tissue-specific expression of thyrotropin-releasing hormone signaling genes in zebrafish and its association with glycemic regulation [0.03%]
促甲状腺释放激素信号通路在斑马鱼发育和组织特异性表达及其与糖稳态的关系研究
David Díaz-Ortegón,Aurea Orozco,Santiago M Pech-Pool et al.
David Díaz-Ortegón et al.
Thyrotropin-releasing hormone (TRH) is a highly conserved tripeptide classically associated with regulation of the hypothalamic-pituitary-thyroid axis; however, TRH and its receptors are also widely distributed in peripheral metabolic tissu...
Binyi Yang,Emily K Mis,Xianglin Zhou et al.
Binyi Yang et al.
During embryogenesis, the establishment of left-right (LR) asymmetry depends on directional fluid flow generated by motile cilia within the left-right organizer (LRO). Disruption of this process can lead to laterality disorders such as situ...
Gelatin-methacryloyl hydrogel stiffness influences epithelial-mesenchymal transition in MCF7 but not MDA-MB-231 breast cancer cells in 3D culture [0.03%]
明胶-甲基丙烯酰胺水凝胶刚度可影响MCF7乳腺癌细胞但不影响MDA-MB-231乳腺癌细胞的上皮间质转化现象
Jessika A Wise,Margaret J Currie,Tim B F Woodfield et al.
Jessika A Wise et al.
This study focuses on advancing the understanding of breast cancer through 3D in vitro models, which provide biomimetic environments superior to many 2D cultures and animal models. Ex vivo analyses show that malignant breast tissues exhibit...
Insights into the zebrafish Left-Right Organizer's Centrosomes and Cilia via Volume Electron Microscopy [0.03%]
基于体积电镜的斑马鱼左右决定器中心体和纤毛研究取得新进展
Favour Ononiwu,Albert Lawrence Adhya,Melissa Mikolaj et al.
Favour Ononiwu et al.
The zebrafish left-right organizer (LRO), Kupffer's vesicle (KV), is a ciliated epithelial organ whose three-dimensional architecture underlies symmetry breaking during embryonic development. While KV cilia have been extensively studied by ...
Antibiotics modulate Escherichia coli-derived bacterial extracellular vesicle production and their upregulation of ICAM-1 in human endothelial cells [0.03%]
抗生素调节大肠杆菌来源的细菌胞外囊泡的产生以及其在人内皮细胞中上调ICAM-1水平
Louis P Widom,Panteha Torabian,Abigail C Wojehowski et al.
Louis P Widom et al.
Antibiotic treatment is often necessary to eliminate life-threatening bacterial infections. However, these treatments can alter production of bacterial extracellular vesicles (BEVs), which often contain pro-inflammatory biomolecules. In thi...
Temporal dynamics of Sertoli and germ cell development in human foetal and prepubertal testis [0.03%]
人类胎儿和青春期前睾丸支持细胞和精原细胞发育的动态变化规律研究
Iris Sanou,Mathangi Lakshmipathi,Lisette K Schönhage et al.
Iris Sanou et al.
Correct development of the testis serves as a springboard for male fertility in adult life, yet our understanding of the timing of human Sertoli and germ cell maturation and their dynamics is incomplete. To map the developmental timeline of...
Behavioral Trait (Co)variances and plasticity in response to turbidity in wild zebrafish (Danio rerio) [0.03%]
野生斑马鱼（Danio rerio）对浑浊度的性状（共）变异性和可塑性响应
Bhavya Pratap Singh,Anuradha Bhat
Bhavya Pratap Singh
Unpredictability of the environments can shape not only the mean behavioral expression but also the structure of behavioral variance within wild populations. Yet, empirical tests integrating individual variation, trait covariances, and corr...
Changes in temperature and precipitation drive shifts in mean flowering timing of tropical plants from 1960-2021 across seven locations [0.03%]
基于1960-2021年七处热带地点的数据探讨温度和降水变化对被子植物开花时间的影响
Skylar Graves,Erin A Manzitto-Tripp
Skylar Graves
It has been shown that changes in plant flowering times are directly tied to climate change, often being the first and most visible indicators of broader, ecosystem-wide change. Despite this, tropical latitudes have been markedly understudi...
aPKC and F-actin dynamics promote hippo pathway polarity in asymmetrically dividing neuroblasts [0.03%]
aPKC和F-肌动蛋白动力学促进不对称分裂神经干细胞中的Hippo通路极性
Niranjan S Joshi,Victoria M Sullivan,Sherzod A Tokamov et al.
Niranjan S Joshi et al.
The Hippo signaling pathway is conventionally known to restrict tissue growth in animals. Genetic studies have also shown that loss of Hippo pathway components leads to defects in asymmetric cell division in Drosophila neural stem cells, kn...
Anjelica Rodriguez-Parks,Ella Grace Beezley,Steffani Manna et al.
Anjelica Rodriguez-Parks et al.
Precise genome editing remains a major challenge in functional genomics, particularly for generating knock-in (KI) alleles in model organisms. Here, we introduce the mini-golden system, a versatile Golden Gate-based subcloning platform that...