Phil Beales,Peter K Jackson
Phil Beales
Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: comparison with the photomultiplier and photodiode methods [0.03%]
高速摄像分析脑室脊液流动的运动模式和速度：与光电倍增管法及光敏二极管法对比研究
Chris O&#x;Callaghan,Kulvinder Sikand,Mark A Chilvers
Chris O&#x;Callaghan
Background: The aim of this study was to compare beat frequency measurements of ependymal cilia made by digital high speed imaging to those obtained using the photomultiplier and modified photodiode techniques. Using high...
Helen L May-Simera,Matthew W Kelley
Helen L May-Simera
Primary cilia have recently been highlighted as key regulators in development and disease. This review focuses on current work demonstrating the broad role of cilia-related proteins in developmental signaling systems. Of particular consider...
Peter K Jackson
Peter K Jackson
Editorial
Cilia. 2012 May 4;1(1):5. DOI:10.1186/2046-2530-1-5 2012
Yi-Chun Hsiao,Karina Tuz,Russell J Ferland
Yi-Chun Hsiao
Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, th...
Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts [0.03%]
主纤毛利用糖蛋白依赖的黏附机制来稳定长时间的纤毛-纤毛接触点
Carolyn Ott,Natalie Elia,Suh Young Jeong et al.
Carolyn Ott et al.
Background: The central tenet of cilia function is sensing and transmitting information. The capacity to directly contact extracellular surfaces would empower primary cilia to probe the environment for information about t...
Marc August Willaredt,Karin Gorgas,Humphrey A R Gardner et al.
Marc August Willaredt et al.
Background: The primary cilium is a microtubule-based, plasma membrane-ensheathed protrusion projecting from the basal bodies of almost all cell types in the mammalian body. In the past several years a plethora of papers ...
Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins [0.03%]
光感受器感觉纤毛和纤毛病：CEP290、RPGR及其相互作用蛋白的研究焦点
Rivka A Rachel,Tiansen Li,Anand Swaroop
Rivka A Rachel
Ciliopathies encompass a broad array of clinical findings associated with genetic defects in biogenesis and/or function of the primary cilium, a ubiquitous organelle involved in the transduction of diverse biological signals. Degeneration o...
Tubby is required for trafficking G protein-coupled receptors to neuronal cilia [0.03%]
Tubby蛋白在G蛋白偶联受体向神经纤毛转运中的作用不可或缺
Xun Sun,James Haley,Oleg V Bulgakov et al.
Xun Sun et al.
Background: Tubby is the founding member of the tubby-like family of proteins. The naturally occurring tubby mutation in mice causes retinitis pigmentosa, hearing loss and obesity. Tubby has been proposed to function as a...
Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis [0.03%]
脊椎动物视黄酸受体在胚胎发育过程中的功能研究取得进展
Raymond C Pasek,Nicolas F Berbari,Wesley R Lewis et al.
Raymond C Pasek et al.
Background: Clusterin associated protein 1 (CLUAP1) was initially characterized as a protein that interacts with clusterin, and whose gene is frequently upregulated in colon cancer. Although the consequences of these obse...